Leptin resensitisation: a reversion of leptin-resistant states

Autores
Andreoli, Maria Florencia; Donato, Jose; Cakir, Isin; Perelló, Mario Carlos
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals. Leptin resensitisation refers to the reversion of leptin-resistant states and is associated with improvement in endocrine and metabolic disturbances commonly observed in obesity and a sustained decrease of plasma leptin levels, possibly below a critical threshold level. In obesity, leptin resensitisation can be achieved with treatments that reduce body adiposity and leptinaemia, or with some pharmacological compounds, while physiological leptin resistance reverts spontaneously. The restoration of leptin sensitivity could be a useful strategy to treat obesity, maintain weight loss and/or reduce the recidivism rate for weight regain after dieting. This review provides an update and discussion about reversion of leptin-resistant states and modulation of the molecular mechanisms involved in each situation.
Instituto Multidisciplinario de Biología Celular
Materia
Biología
Medicina
diet-induced obesity
leptin resistance
obesity
leptin resensitisation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/141470
Acceder
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network_name_str SEDICI (UNLP)
spelling Leptin resensitisation: a reversion of leptin-resistant statesAndreoli, Maria FlorenciaDonato, JoseCakir, IsinPerelló, Mario CarlosBiologíaMedicinadiet-induced obesityleptin resistanceobesityleptin resensitisationLeptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals. Leptin resensitisation refers to the reversion of leptin-resistant states and is associated with improvement in endocrine and metabolic disturbances commonly observed in obesity and a sustained decrease of plasma leptin levels, possibly below a critical threshold level. In obesity, leptin resensitisation can be achieved with treatments that reduce body adiposity and leptinaemia, or with some pharmacological compounds, while physiological leptin resistance reverts spontaneously. The restoration of leptin sensitivity could be a useful strategy to treat obesity, maintain weight loss and/or reduce the recidivism rate for weight regain after dieting. This review provides an update and discussion about reversion of leptin-resistant states and modulation of the molecular mechanisms involved in each situation.Instituto Multidisciplinario de Biología Celular2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfR81-R96http://sedici.unlp.edu.ar/handle/10915/141470enginfo:eu-repo/semantics/altIdentifier/issn/1479-6805info:eu-repo/semantics/altIdentifier/issn/0022-0795info:eu-repo/semantics/altIdentifier/doi/10.1530/joe-18-0606info:eu-repo/semantics/altIdentifier/pmid/30959481info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:04:28Zoai:sedici.unlp.edu.ar:10915/141470Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:04:28.246SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Leptin resensitisation: a reversion of leptin-resistant states
title Leptin resensitisation: a reversion of leptin-resistant states
spellingShingle Leptin resensitisation: a reversion of leptin-resistant states
Andreoli, Maria Florencia
Biología
Medicina
diet-induced obesity
leptin resistance
obesity
leptin resensitisation
title_short Leptin resensitisation: a reversion of leptin-resistant states
title_full Leptin resensitisation: a reversion of leptin-resistant states
title_fullStr Leptin resensitisation: a reversion of leptin-resistant states
title_full_unstemmed Leptin resensitisation: a reversion of leptin-resistant states
title_sort Leptin resensitisation: a reversion of leptin-resistant states
dc.creator.none.fl_str_mv Andreoli, Maria Florencia
Donato, Jose
Cakir, Isin
Perelló, Mario Carlos
author Andreoli, Maria Florencia
author_facet Andreoli, Maria Florencia
Donato, Jose
Cakir, Isin
Perelló, Mario Carlos
author_role author
author2 Donato, Jose
Cakir, Isin
Perelló, Mario Carlos
author2_role author
author
author
dc.subject.none.fl_str_mv Biología
Medicina
diet-induced obesity
leptin resistance
obesity
leptin resensitisation
topic Biología
Medicina
diet-induced obesity
leptin resistance
obesity
leptin resensitisation
dc.description.none.fl_txt_mv Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals. Leptin resensitisation refers to the reversion of leptin-resistant states and is associated with improvement in endocrine and metabolic disturbances commonly observed in obesity and a sustained decrease of plasma leptin levels, possibly below a critical threshold level. In obesity, leptin resensitisation can be achieved with treatments that reduce body adiposity and leptinaemia, or with some pharmacological compounds, while physiological leptin resistance reverts spontaneously. The restoration of leptin sensitivity could be a useful strategy to treat obesity, maintain weight loss and/or reduce the recidivism rate for weight regain after dieting. This review provides an update and discussion about reversion of leptin-resistant states and modulation of the molecular mechanisms involved in each situation.
Instituto Multidisciplinario de Biología Celular
description Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals. Leptin resensitisation refers to the reversion of leptin-resistant states and is associated with improvement in endocrine and metabolic disturbances commonly observed in obesity and a sustained decrease of plasma leptin levels, possibly below a critical threshold level. In obesity, leptin resensitisation can be achieved with treatments that reduce body adiposity and leptinaemia, or with some pharmacological compounds, while physiological leptin resistance reverts spontaneously. The restoration of leptin sensitivity could be a useful strategy to treat obesity, maintain weight loss and/or reduce the recidivism rate for weight regain after dieting. This review provides an update and discussion about reversion of leptin-resistant states and modulation of the molecular mechanisms involved in each situation.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/141470
url http://sedici.unlp.edu.ar/handle/10915/141470
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1479-6805
info:eu-repo/semantics/altIdentifier/issn/0022-0795
info:eu-repo/semantics/altIdentifier/doi/10.1530/joe-18-0606
info:eu-repo/semantics/altIdentifier/pmid/30959481
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
R81-R96
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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