Multiscale intracranial EEG dynamics across sleep–wake states: toward memory-related processing

• Autores: Tenti, Juan Martín; Pallares Di Nunzio, Monserrat; Bab, Marisa Alejandra; Rosso, Osvaldo Aníbal; Montani, Fernando Fabián; Arlego, Marcelo José Fabián
• Año de publicación: 2025
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Biología; sleep; memory consolidation; intracranial EEG; neural dynamics; multiscale analysis; cortical regions; temporal correlations; avalanche dynamics
• Institución: Universidad Nacional de La Plata

Sleep is known to support memory consolidation through a complex interplay of neural dynamics across multiple timescales. Using intracranial EEG (iEEG) recordings from patients undergoing clinical monitoring, we characterize spectral activity, neuronal avalanche dynamics, and temporal correlations across sleep-wake states, with a focus on their spatial distribution and potential functional relevance. We observe increased low-frequency power, larger avalanches, and enhanced long-range temporal correlations-quantified via Detrended Fluctuation Analysis-during N2 and N3 sleep. In contrast, REM sleep and wakefulness show reduced temporal persistence and fewer large-scale cascades, suggesting a shift toward more fragmented and flexible dynamics. These signatures vary across cortical regions, with distinctive patterns emerging in medial temporal and frontal areas-regions implicated in memory processing. Rather than providing direct evidence of consolidation, our results point to a functional neural landscape that may favor both stabilization and reconfiguration of internal representations during sleep. Overall, our findings highlight the utility of iEEG in revealing the multiscale spatio-temporal structure of sleep-related brain dynamics, offering insights into the physiological conditions that support memory-related processing.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Instituto de Física La Plata