Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I

Autores
Rodríguez, Gaspar
Año de publicación
2017
Idioma
español castellano
Tipo de recurso
tesis de grado
Estado
versión aceptada
Colaborador/a o director/a de tesis
Bellini, María José
Falomir Lockhart, Eugenia
Descripción
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder which manifests as a motor disorder, characterized by slowness of movements, rigidity and tremor. Motor dysfunction of PD is due to dopamine loss in the neostriatum and due to the neurodegeneration of dopaminergic neuron’s cell bodies of the Substantia Nigra Pars Compacta (SNPC). Evidence suggests that chronic neuroinflammation, mediated by activated microglial and astroglial cells in the SNPC, could be essential for the degenerative process. It is well known that IGF1 plays a key role in neuroprotection in physiological conditions, both in health and disease. Previous studies of our group have shown that Rad-IGF ICV gene therapy had a restorative effect on motor skills of aged rats.
Licenciado en Biotecnología y Biología Molecular
Universidad Nacional de La Plata
Facultad de Ciencias Exactas
Materia
Biología
IGF-1
Enfermedad de Parkinson
Enfermedades Neurodegenerativas
alfa-Sinucleína
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/64897
Acceder
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network_name_str SEDICI (UNLP)
spelling Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-IRodríguez, GasparBiologíaIGF-1Enfermedad de ParkinsonEnfermedades Neurodegenerativasalfa-SinucleínaParkinson’s Disease (PD) is a progressive neurodegenerative disorder which manifests as a motor disorder, characterized by slowness of movements, rigidity and tremor. Motor dysfunction of PD is due to dopamine loss in the neostriatum and due to the neurodegeneration of dopaminergic neuron’s cell bodies of the Substantia Nigra Pars Compacta (SNPC). Evidence suggests that chronic neuroinflammation, mediated by activated microglial and astroglial cells in the SNPC, could be essential for the degenerative process. It is well known that IGF1 plays a key role in neuroprotection in physiological conditions, both in health and disease. Previous studies of our group have shown that Rad-IGF ICV gene therapy had a restorative effect on motor skills of aged rats.Licenciado en Biotecnología y Biología MolecularUniversidad Nacional de La PlataFacultad de Ciencias ExactasBellini, María JoséFalomir Lockhart, Eugenia2017-12-20info:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionTesis de gradohttp://purl.org/coar/resource_type/c_7a1finfo:ar-repo/semantics/tesisDeGradoapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/64897spainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:01:21Zoai:sedici.unlp.edu.ar:10915/64897Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:01:21.851SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
spellingShingle Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
Rodríguez, Gaspar
Biología
IGF-1
Enfermedad de Parkinson
Enfermedades Neurodegenerativas
alfa-Sinucleína
title_short Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_full Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_fullStr Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_full_unstemmed Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_sort Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
dc.creator.none.fl_str_mv Rodríguez, Gaspar
author Rodríguez, Gaspar
author_facet Rodríguez, Gaspar
author_role author
dc.contributor.none.fl_str_mv Bellini, María José
Falomir Lockhart, Eugenia
dc.subject.none.fl_str_mv Biología
IGF-1
Enfermedad de Parkinson
Enfermedades Neurodegenerativas
alfa-Sinucleína
topic Biología
IGF-1
Enfermedad de Parkinson
Enfermedades Neurodegenerativas
alfa-Sinucleína
dc.description.none.fl_txt_mv Parkinson’s Disease (PD) is a progressive neurodegenerative disorder which manifests as a motor disorder, characterized by slowness of movements, rigidity and tremor. Motor dysfunction of PD is due to dopamine loss in the neostriatum and due to the neurodegeneration of dopaminergic neuron’s cell bodies of the Substantia Nigra Pars Compacta (SNPC). Evidence suggests that chronic neuroinflammation, mediated by activated microglial and astroglial cells in the SNPC, could be essential for the degenerative process. It is well known that IGF1 plays a key role in neuroprotection in physiological conditions, both in health and disease. Previous studies of our group have shown that Rad-IGF ICV gene therapy had a restorative effect on motor skills of aged rats.
Licenciado en Biotecnología y Biología Molecular
Universidad Nacional de La Plata
Facultad de Ciencias Exactas
description Parkinson’s Disease (PD) is a progressive neurodegenerative disorder which manifests as a motor disorder, characterized by slowness of movements, rigidity and tremor. Motor dysfunction of PD is due to dopamine loss in the neostriatum and due to the neurodegeneration of dopaminergic neuron’s cell bodies of the Substantia Nigra Pars Compacta (SNPC). Evidence suggests that chronic neuroinflammation, mediated by activated microglial and astroglial cells in the SNPC, could be essential for the degenerative process. It is well known that IGF1 plays a key role in neuroprotection in physiological conditions, both in health and disease. Previous studies of our group have shown that Rad-IGF ICV gene therapy had a restorative effect on motor skills of aged rats.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-20
dc.type.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
info:eu-repo/semantics/acceptedVersion
Tesis de grado
http://purl.org/coar/resource_type/c_7a1f
info:ar-repo/semantics/tesisDeGrado
format bachelorThesis
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/64897
url http://sedici.unlp.edu.ar/handle/10915/64897
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.22299

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