Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9

Autores
Laguens, Graciela; Coronato, Silvia; Chambó, Jorge; Di Girolamo, María Teresa Vanda
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The interaction between some chemokines with tumoral and stromal cells can influence tumor progression. CXCL9, a monokine induced by interferon gamma (MIG), targets lymphocytes. The aim of our study was to identify and quantify CD4+ and CD8+ T cells in the stroma of human breast cancer and correlate them with the presence of MIG/CXCL9. In 58 specimens of human breast carcinoma and 10 normal breast tissue from mammoplasty surgery, immunohistochemis- try and ELISA methods were performed. The number of CD4+ and CD8+ T cells in breast cancer tissue was signifi-cantly increased compared with normal breast tissue with a clear predominance of CD8+ T cells. MIG/CXCL9 levels were significantly elevated respect normal breast tissue. This chemokine correlated with the number of CD8+ T cells only in non-metastatic tumors. These data suggest that MIG targets cytotoxic T cells. Their recruitment into breast car-cinoma can play a critical role in malignant progression, inhibiting the production of metastasis.
Facultad de Ciencias Médicas (FCM)
Materia
Ciencias Médicas
Breast Cancer
CD4+ T cells
CD8+ T Cells’ MIG/CXCL9
Chemokines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/81072
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/81072
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9Laguens, GracielaCoronato, SilviaChambó, JorgeDi Girolamo, María Teresa VandaCiencias MédicasBreast CancerCD4+ T cellsCD8+ T Cells’ MIG/CXCL9ChemokinesThe interaction between some chemokines with tumoral and stromal cells can influence tumor progression. CXCL9, a monokine induced by interferon gamma (MIG), targets lymphocytes. The aim of our study was to identify and quantify CD4+ and CD8+ T cells in the stroma of human breast cancer and correlate them with the presence of MIG/CXCL9. In 58 specimens of human breast carcinoma and 10 normal breast tissue from mammoplasty surgery, immunohistochemis- try and ELISA methods were performed. The number of CD4+ and CD8+ T cells in breast cancer tissue was signifi-cantly increased compared with normal breast tissue with a clear predominance of CD8+ T cells. MIG/CXCL9 levels were significantly elevated respect normal breast tissue. This chemokine correlated with the number of CD8+ T cells only in non-metastatic tumors. These data suggest that MIG targets cytotoxic T cells. Their recruitment into breast car-cinoma can play a critical role in malignant progression, inhibiting the production of metastasis.Facultad de Ciencias Médicas (FCM)2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf7-11http://sedici.unlp.edu.ar/handle/10915/81072enginfo:eu-repo/semantics/altIdentifier/issn/2168-1597info:eu-repo/semantics/altIdentifier/doi/10.4236/abcr.2012.12002info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-11-05T12:54:26Zoai:sedici.unlp.edu.ar:10915/81072Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-11-05 12:54:26.591SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
spellingShingle Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
Laguens, Graciela
Ciencias Médicas
Breast Cancer
CD4+ T cells
CD8+ T Cells’ MIG/CXCL9
Chemokines
title_short Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_full Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_fullStr Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_full_unstemmed Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_sort Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
dc.creator.none.fl_str_mv Laguens, Graciela
Coronato, Silvia
Chambó, Jorge
Di Girolamo, María Teresa Vanda
author Laguens, Graciela
author_facet Laguens, Graciela
Coronato, Silvia
Chambó, Jorge
Di Girolamo, María Teresa Vanda
author_role author
author2 Coronato, Silvia
Chambó, Jorge
Di Girolamo, María Teresa Vanda
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Breast Cancer
CD4+ T cells
CD8+ T Cells’ MIG/CXCL9
Chemokines
topic Ciencias Médicas
Breast Cancer
CD4+ T cells
CD8+ T Cells’ MIG/CXCL9
Chemokines
dc.description.none.fl_txt_mv The interaction between some chemokines with tumoral and stromal cells can influence tumor progression. CXCL9, a monokine induced by interferon gamma (MIG), targets lymphocytes. The aim of our study was to identify and quantify CD4+ and CD8+ T cells in the stroma of human breast cancer and correlate them with the presence of MIG/CXCL9. In 58 specimens of human breast carcinoma and 10 normal breast tissue from mammoplasty surgery, immunohistochemis- try and ELISA methods were performed. The number of CD4+ and CD8+ T cells in breast cancer tissue was signifi-cantly increased compared with normal breast tissue with a clear predominance of CD8+ T cells. MIG/CXCL9 levels were significantly elevated respect normal breast tissue. This chemokine correlated with the number of CD8+ T cells only in non-metastatic tumors. These data suggest that MIG targets cytotoxic T cells. Their recruitment into breast car-cinoma can play a critical role in malignant progression, inhibiting the production of metastasis.
Facultad de Ciencias Médicas (FCM)
description The interaction between some chemokines with tumoral and stromal cells can influence tumor progression. CXCL9, a monokine induced by interferon gamma (MIG), targets lymphocytes. The aim of our study was to identify and quantify CD4+ and CD8+ T cells in the stroma of human breast cancer and correlate them with the presence of MIG/CXCL9. In 58 specimens of human breast carcinoma and 10 normal breast tissue from mammoplasty surgery, immunohistochemis- try and ELISA methods were performed. The number of CD4+ and CD8+ T cells in breast cancer tissue was signifi-cantly increased compared with normal breast tissue with a clear predominance of CD8+ T cells. MIG/CXCL9 levels were significantly elevated respect normal breast tissue. This chemokine correlated with the number of CD8+ T cells only in non-metastatic tumors. These data suggest that MIG targets cytotoxic T cells. Their recruitment into breast car-cinoma can play a critical role in malignant progression, inhibiting the production of metastasis.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/81072
url http://sedici.unlp.edu.ar/handle/10915/81072
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2168-1597
info:eu-repo/semantics/altIdentifier/doi/10.4236/abcr.2012.12002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
7-11
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.087074

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