A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Rele...
- Autores
- Abate, Pedro Oscar; Sottile, Marco; León, Ignacio Esteban; Vergara, Mónica M.; Katz, Néstor E.
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A new dinuclear complex of formula [{Re(CO)₃(py)}₂(μ-4,4”-azobpy)](PF₆)₂, with py = pyridine and 4,4”-azobpy = 4,4”-azobis(2,2’-bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by nuclear magnetic resonance (NMR) measurements. When adding L-cysteine or L-glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data.
Facultad de Ciencias Exactas
Centro de Química Inorgánica - Materia
-
Ciencias Exactas
Química
rhenium
thiol detection
chemotherapy - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/123623
Ver los metadatos del registro completo
| id |
SEDICI_39fdfef5e7c184345d2b186acfe99286 |
|---|---|
| oai_identifier_str |
oai:sedici.unlp.edu.ar:10915/123623 |
| network_acronym_str |
SEDICI |
| repository_id_str |
1329 |
| network_name_str |
SEDICI (UNLP) |
| spelling |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone CancerAbate, Pedro OscarSottile, MarcoLeón, Ignacio EstebanVergara, Mónica M.Katz, Néstor E.Ciencias ExactasQuímicarheniumthiol detectionchemotherapyA new dinuclear complex of formula [{Re(CO)₃(py)}₂(μ-4,4”-azobpy)](PF₆)₂, with py = pyridine and 4,4”-azobpy = 4,4”-azobis(2,2’-bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by nuclear magnetic resonance (NMR) measurements. When adding L-cysteine or L-glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data.Facultad de Ciencias ExactasCentro de Química Inorgánica2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf2299-2306http://sedici.unlp.edu.ar/handle/10915/123623enginfo:eu-repo/semantics/altIdentifier/issn/0103-5053info:eu-repo/semantics/altIdentifier/doi/10.21577/0103-5053.20200085info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:28Zoai:sedici.unlp.edu.ar:10915/123623Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:28.89SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| spellingShingle |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer Abate, Pedro Oscar Ciencias Exactas Química rhenium thiol detection chemotherapy |
| title_short |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_full |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_fullStr |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_full_unstemmed |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_sort |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| dc.creator.none.fl_str_mv |
Abate, Pedro Oscar Sottile, Marco León, Ignacio Esteban Vergara, Mónica M. Katz, Néstor E. |
| author |
Abate, Pedro Oscar |
| author_facet |
Abate, Pedro Oscar Sottile, Marco León, Ignacio Esteban Vergara, Mónica M. Katz, Néstor E. |
| author_role |
author |
| author2 |
Sottile, Marco León, Ignacio Esteban Vergara, Mónica M. Katz, Néstor E. |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Ciencias Exactas Química rhenium thiol detection chemotherapy |
| topic |
Ciencias Exactas Química rhenium thiol detection chemotherapy |
| dc.description.none.fl_txt_mv |
A new dinuclear complex of formula [{Re(CO)₃(py)}₂(μ-4,4”-azobpy)](PF₆)₂, with py = pyridine and 4,4”-azobpy = 4,4”-azobis(2,2’-bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by nuclear magnetic resonance (NMR) measurements. When adding L-cysteine or L-glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data. Facultad de Ciencias Exactas Centro de Química Inorgánica |
| description |
A new dinuclear complex of formula [{Re(CO)₃(py)}₂(μ-4,4”-azobpy)](PF₆)₂, with py = pyridine and 4,4”-azobpy = 4,4”-azobis(2,2’-bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by nuclear magnetic resonance (NMR) measurements. When adding L-cysteine or L-glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/123623 |
| url |
http://sedici.unlp.edu.ar/handle/10915/123623 |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0103-5053 info:eu-repo/semantics/altIdentifier/doi/10.21577/0103-5053.20200085 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
| dc.format.none.fl_str_mv |
application/pdf 2299-2306 |
| dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
| reponame_str |
SEDICI (UNLP) |
| collection |
SEDICI (UNLP) |
| instname_str |
Universidad Nacional de La Plata |
| instacron_str |
UNLP |
| institution |
UNLP |
| repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
| repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
| _version_ |
1844616173769981952 |
| score |
13.070432 |