Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring

Autores
Chisari, Andrea Nancy; Giovambattista, Andrés; Perelló, Mario Carlos; Spinedi, Eduardo Julio
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Malnutrition induces profound deleterious effects on several metabolic and neuroendocrine functions. In the present study, we examined the impact of maternal food restriction, during gestation and lactation, on the metabolic-neuroendocrine function of their male offspring at 21 and 60 d of age. Well-nourished (WN) and undernourished (UN) pregnant rats were used, during gestation and lactation, until pups were weaned. Twenty-one-day-old WN and UN male pups were studied in basal and postinsulin conditions. Additional groups of weaned (WN and UN) male rats were fed either ad libitum (WN-WN and UN-WN) or in a restricted fashion (WN-UN and UN-UN) until experimentation at age 60 d. Body weights of mothers and their male offspring were monitored. Basal and post-insulin plasma concentrations of several metabolic fuels were evaluated. Our results indicate that 21-d-old UN male rats exhibited (vs their WN counterparts), decreased body weights, similar basal and postinsulin glycemia, similar basal plasma adrenocorticotropic hormone (ACTH) and corticosterone levels but diminished ACTH response to insulin treatment, and basal hypoleptinemia and significant insulin-induced leptin release. Finally, at 60 d of age, long-term UN (WN-UN and UN-UN) rats showed lower plasma (basal and postinsulin) glucose, and basal triglyceride levels than their counterparts (WN-WN and UN-WN). Sixty-day-old rats submitted to either food restriction protocol also showed a reduced hypothalamo-pituitary-adrenalaxis response to insulin-induced hypoglycemia and basal hypoleptinemia, in spite of restoration of normal body weights. These results further indicate a clear metabolic-neuroendocrine dysfunction in male pups of UN mothers, with the abnormality partially present at weaning and deteriorated by adulthood, even after the recovery of normal body weight. Our study strongly supports the importance of the irreversibility of a deleterious allostatic state resulting from fetal and early postnatal undernutrition.
Facultad de Ciencias Exactas
Instituto Multidisciplinario de Biología Celular
Materia
Ciencias Exactas
Biología
adrenocorticotropic hormone
glucocorticoid
carbohydrate
leptin
foodrestriction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/131261

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network_name_str SEDICI (UNLP)
spelling Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat OffspringChisari, Andrea NancyGiovambattista, AndrésPerelló, Mario CarlosSpinedi, Eduardo JulioCiencias ExactasBiologíaadrenocorticotropic hormoneglucocorticoidcarbohydrateleptinfoodrestrictionMalnutrition induces profound deleterious effects on several metabolic and neuroendocrine functions. In the present study, we examined the impact of maternal food restriction, during gestation and lactation, on the metabolic-neuroendocrine function of their male offspring at 21 and 60 d of age. Well-nourished (WN) and undernourished (UN) pregnant rats were used, during gestation and lactation, until pups were weaned. Twenty-one-day-old WN and UN male pups were studied in basal and postinsulin conditions. Additional groups of weaned (WN and UN) male rats were fed either ad libitum (WN-WN and UN-WN) or in a restricted fashion (WN-UN and UN-UN) until experimentation at age 60 d. Body weights of mothers and their male offspring were monitored. Basal and post-insulin plasma concentrations of several metabolic fuels were evaluated. Our results indicate that 21-d-old UN male rats exhibited (vs their WN counterparts), decreased body weights, similar basal and postinsulin glycemia, similar basal plasma adrenocorticotropic hormone (ACTH) and corticosterone levels but diminished ACTH response to insulin treatment, and basal hypoleptinemia and significant insulin-induced leptin release. Finally, at 60 d of age, long-term UN (WN-UN and UN-UN) rats showed lower plasma (basal and postinsulin) glucose, and basal triglyceride levels than their counterparts (WN-WN and UN-WN). Sixty-day-old rats submitted to either food restriction protocol also showed a reduced hypothalamo-pituitary-adrenalaxis response to insulin-induced hypoglycemia and basal hypoleptinemia, in spite of restoration of normal body weights. These results further indicate a clear metabolic-neuroendocrine dysfunction in male pups of UN mothers, with the abnormality partially present at weaning and deteriorated by adulthood, even after the recovery of normal body weight. Our study strongly supports the importance of the irreversibility of a deleterious allostatic state resulting from fetal and early postnatal undernutrition.Facultad de Ciencias ExactasInstituto Multidisciplinario de Biología Celular2001info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf375-382http://sedici.unlp.edu.ar/handle/10915/131261enginfo:eu-repo/semantics/altIdentifier/issn/1355-008Xinfo:eu-repo/semantics/altIdentifier/issn/0969-711Xinfo:eu-repo/semantics/altIdentifier/doi/10.1385/endo:14:3:375info:eu-repo/semantics/altIdentifier/pmid/11444436info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:31Zoai:sedici.unlp.edu.ar:10915/131261Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:32.208SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
spellingShingle Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
Chisari, Andrea Nancy
Ciencias Exactas
Biología
adrenocorticotropic hormone
glucocorticoid
carbohydrate
leptin
foodrestriction
title_short Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_full Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_fullStr Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_full_unstemmed Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_sort Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
dc.creator.none.fl_str_mv Chisari, Andrea Nancy
Giovambattista, Andrés
Perelló, Mario Carlos
Spinedi, Eduardo Julio
author Chisari, Andrea Nancy
author_facet Chisari, Andrea Nancy
Giovambattista, Andrés
Perelló, Mario Carlos
Spinedi, Eduardo Julio
author_role author
author2 Giovambattista, Andrés
Perelló, Mario Carlos
Spinedi, Eduardo Julio
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Biología
adrenocorticotropic hormone
glucocorticoid
carbohydrate
leptin
foodrestriction
topic Ciencias Exactas
Biología
adrenocorticotropic hormone
glucocorticoid
carbohydrate
leptin
foodrestriction
dc.description.none.fl_txt_mv Malnutrition induces profound deleterious effects on several metabolic and neuroendocrine functions. In the present study, we examined the impact of maternal food restriction, during gestation and lactation, on the metabolic-neuroendocrine function of their male offspring at 21 and 60 d of age. Well-nourished (WN) and undernourished (UN) pregnant rats were used, during gestation and lactation, until pups were weaned. Twenty-one-day-old WN and UN male pups were studied in basal and postinsulin conditions. Additional groups of weaned (WN and UN) male rats were fed either ad libitum (WN-WN and UN-WN) or in a restricted fashion (WN-UN and UN-UN) until experimentation at age 60 d. Body weights of mothers and their male offspring were monitored. Basal and post-insulin plasma concentrations of several metabolic fuels were evaluated. Our results indicate that 21-d-old UN male rats exhibited (vs their WN counterparts), decreased body weights, similar basal and postinsulin glycemia, similar basal plasma adrenocorticotropic hormone (ACTH) and corticosterone levels but diminished ACTH response to insulin treatment, and basal hypoleptinemia and significant insulin-induced leptin release. Finally, at 60 d of age, long-term UN (WN-UN and UN-UN) rats showed lower plasma (basal and postinsulin) glucose, and basal triglyceride levels than their counterparts (WN-WN and UN-WN). Sixty-day-old rats submitted to either food restriction protocol also showed a reduced hypothalamo-pituitary-adrenalaxis response to insulin-induced hypoglycemia and basal hypoleptinemia, in spite of restoration of normal body weights. These results further indicate a clear metabolic-neuroendocrine dysfunction in male pups of UN mothers, with the abnormality partially present at weaning and deteriorated by adulthood, even after the recovery of normal body weight. Our study strongly supports the importance of the irreversibility of a deleterious allostatic state resulting from fetal and early postnatal undernutrition.
Facultad de Ciencias Exactas
Instituto Multidisciplinario de Biología Celular
description Malnutrition induces profound deleterious effects on several metabolic and neuroendocrine functions. In the present study, we examined the impact of maternal food restriction, during gestation and lactation, on the metabolic-neuroendocrine function of their male offspring at 21 and 60 d of age. Well-nourished (WN) and undernourished (UN) pregnant rats were used, during gestation and lactation, until pups were weaned. Twenty-one-day-old WN and UN male pups were studied in basal and postinsulin conditions. Additional groups of weaned (WN and UN) male rats were fed either ad libitum (WN-WN and UN-WN) or in a restricted fashion (WN-UN and UN-UN) until experimentation at age 60 d. Body weights of mothers and their male offspring were monitored. Basal and post-insulin plasma concentrations of several metabolic fuels were evaluated. Our results indicate that 21-d-old UN male rats exhibited (vs their WN counterparts), decreased body weights, similar basal and postinsulin glycemia, similar basal plasma adrenocorticotropic hormone (ACTH) and corticosterone levels but diminished ACTH response to insulin treatment, and basal hypoleptinemia and significant insulin-induced leptin release. Finally, at 60 d of age, long-term UN (WN-UN and UN-UN) rats showed lower plasma (basal and postinsulin) glucose, and basal triglyceride levels than their counterparts (WN-WN and UN-WN). Sixty-day-old rats submitted to either food restriction protocol also showed a reduced hypothalamo-pituitary-adrenalaxis response to insulin-induced hypoglycemia and basal hypoleptinemia, in spite of restoration of normal body weights. These results further indicate a clear metabolic-neuroendocrine dysfunction in male pups of UN mothers, with the abnormality partially present at weaning and deteriorated by adulthood, even after the recovery of normal body weight. Our study strongly supports the importance of the irreversibility of a deleterious allostatic state resulting from fetal and early postnatal undernutrition.
publishDate 2001
dc.date.none.fl_str_mv 2001
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/131261
url http://sedici.unlp.edu.ar/handle/10915/131261
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language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1355-008X
info:eu-repo/semantics/altIdentifier/issn/0969-711X
info:eu-repo/semantics/altIdentifier/doi/10.1385/endo:14:3:375
info:eu-repo/semantics/altIdentifier/pmid/11444436
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
375-382
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instname:Universidad Nacional de La Plata
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reponame_str SEDICI (UNLP)
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