Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study
- Autores
- Ferraresi Curotto, Verónica; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; Pis Diez, Reinaldo; González Baró, Ana Cecilia
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A family of hydrazones of isoniazid and a group of hydroxybenzalaldehydes (vanillin, 5-bromovanillin, 5- chlorosalicylaldehyde and 5-bromosalicylaldehyde) were obtained and fully characterized. The results, including theoretical data, are comparatively analyzed along with the already reported hydrazone of ovanillin. The crystal structures of three compounds were determined. The hydrazones obtained from halogenated aldehydes are isomorphic and chiral to each other. Structures are further stabilized by (pyr) NHþ/Cl and OwH/Cl bonds. The vanillin hydrazone shows a conformer that differs from the previously reported. Neighboring molecules are linked to each other through OH/N(pyr) bonds, giving rise to a nearly planar polymeric structure. The conformational space was searched and geometries were optimized both in the gas phase and including solvent effects by DFT. Results are extended to describe the 5-bromovanillin hydrazone. FTIR, NMR and electronic spectra were measured and assigned with the help of computational calculations.
Centro de Química Inorgánica
Instituto de Física La Plata - Materia
-
Química
Crystal structures
Spectroscopy
DFT calculations
Isoniazid
Schiff bases - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/146964
Ver los metadatos del registro completo
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Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical studyFerraresi Curotto, VerónicaEcheverría, Gustavo AlbertoPiro, Oscar EnriquePis Diez, ReinaldoGonzález Baró, Ana CeciliaQuímicaCrystal structuresSpectroscopyDFT calculationsIsoniazidSchiff basesA family of hydrazones of isoniazid and a group of hydroxybenzalaldehydes (vanillin, 5-bromovanillin, 5- chlorosalicylaldehyde and 5-bromosalicylaldehyde) were obtained and fully characterized. The results, including theoretical data, are comparatively analyzed along with the already reported hydrazone of ovanillin. The crystal structures of three compounds were determined. The hydrazones obtained from halogenated aldehydes are isomorphic and chiral to each other. Structures are further stabilized by (pyr) NHþ/Cl and OwH/Cl bonds. The vanillin hydrazone shows a conformer that differs from the previously reported. Neighboring molecules are linked to each other through OH/N(pyr) bonds, giving rise to a nearly planar polymeric structure. The conformational space was searched and geometries were optimized both in the gas phase and including solvent effects by DFT. Results are extended to describe the 5-bromovanillin hydrazone. FTIR, NMR and electronic spectra were measured and assigned with the help of computational calculations.Centro de Química InorgánicaInstituto de Física La Plata2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf436-447http://sedici.unlp.edu.ar/handle/10915/146964enginfo:eu-repo/semantics/altIdentifier/issn/0022-2860info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molstruc.2016.12.018info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:37:32Zoai:sedici.unlp.edu.ar:10915/146964Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:37:32.606SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study |
title |
Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study |
spellingShingle |
Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study Ferraresi Curotto, Verónica Química Crystal structures Spectroscopy DFT calculations Isoniazid Schiff bases |
title_short |
Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study |
title_full |
Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study |
title_fullStr |
Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study |
title_full_unstemmed |
Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study |
title_sort |
Synthesis and characterization of a series of isoniazid hydrazones : Spectroscopic and theoretical study |
dc.creator.none.fl_str_mv |
Ferraresi Curotto, Verónica Echeverría, Gustavo Alberto Piro, Oscar Enrique Pis Diez, Reinaldo González Baró, Ana Cecilia |
author |
Ferraresi Curotto, Verónica |
author_facet |
Ferraresi Curotto, Verónica Echeverría, Gustavo Alberto Piro, Oscar Enrique Pis Diez, Reinaldo González Baró, Ana Cecilia |
author_role |
author |
author2 |
Echeverría, Gustavo Alberto Piro, Oscar Enrique Pis Diez, Reinaldo González Baró, Ana Cecilia |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Química Crystal structures Spectroscopy DFT calculations Isoniazid Schiff bases |
topic |
Química Crystal structures Spectroscopy DFT calculations Isoniazid Schiff bases |
dc.description.none.fl_txt_mv |
A family of hydrazones of isoniazid and a group of hydroxybenzalaldehydes (vanillin, 5-bromovanillin, 5- chlorosalicylaldehyde and 5-bromosalicylaldehyde) were obtained and fully characterized. The results, including theoretical data, are comparatively analyzed along with the already reported hydrazone of ovanillin. The crystal structures of three compounds were determined. The hydrazones obtained from halogenated aldehydes are isomorphic and chiral to each other. Structures are further stabilized by (pyr) NHþ/Cl and OwH/Cl bonds. The vanillin hydrazone shows a conformer that differs from the previously reported. Neighboring molecules are linked to each other through OH/N(pyr) bonds, giving rise to a nearly planar polymeric structure. The conformational space was searched and geometries were optimized both in the gas phase and including solvent effects by DFT. Results are extended to describe the 5-bromovanillin hydrazone. FTIR, NMR and electronic spectra were measured and assigned with the help of computational calculations. Centro de Química Inorgánica Instituto de Física La Plata |
description |
A family of hydrazones of isoniazid and a group of hydroxybenzalaldehydes (vanillin, 5-bromovanillin, 5- chlorosalicylaldehyde and 5-bromosalicylaldehyde) were obtained and fully characterized. The results, including theoretical data, are comparatively analyzed along with the already reported hydrazone of ovanillin. The crystal structures of three compounds were determined. The hydrazones obtained from halogenated aldehydes are isomorphic and chiral to each other. Structures are further stabilized by (pyr) NHþ/Cl and OwH/Cl bonds. The vanillin hydrazone shows a conformer that differs from the previously reported. Neighboring molecules are linked to each other through OH/N(pyr) bonds, giving rise to a nearly planar polymeric structure. The conformational space was searched and geometries were optimized both in the gas phase and including solvent effects by DFT. Results are extended to describe the 5-bromovanillin hydrazone. FTIR, NMR and electronic spectra were measured and assigned with the help of computational calculations. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/146964 |
url |
http://sedici.unlp.edu.ar/handle/10915/146964 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0022-2860 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molstruc.2016.12.018 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
dc.format.none.fl_str_mv |
application/pdf 436-447 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
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Universidad Nacional de La Plata |
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UNLP |
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UNLP |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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alira@sedici.unlp.edu.ar |
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