Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia

Autores
El-Rifai, Wael; Elonen, Erkki; Larramendy, Marcelo Luis; Ruutu, Tapani; Knuutila, Sakari
Año de publicación
1997
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Comparative genomic hybridization (CGH) was used to detect changes in DNA copy number in 25 cases of refractory acute myeloid leukemia (AML). CGH detected changes in DNA copy number in nine AML (36%). Losses (82%) were more frequent than gains (18%). No high-level amplifications were detected in any of the cases. Losses involved minimal overlapping regions at 5q14q32, 7q31.2q32 and 12p12. The most frequent gain was detected at 8q. CGH gave normal results in all cases with a normal karyotype or a translocation as the sole aberration. The absence of high-level DNA copy gains suggests that, in contrast to other malignancies, gene amplification is not an important mechanism for drug resistance in AML. In addition to 5q and 7q, known to be associated with disease refractoriness, 12p may be another region related to poor prognosis.
Facultad de Ciencias Naturales y Museo
Materia
Biología
Ciencias Médicas
CGH
refractory AML
5q; 7q
12p
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/132500
Acceder
id SEDICI_2a86f8b5d2821d3c0061eb02225de05d
oai_identifier_str oai:sedici.unlp.edu.ar:10915/132500
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemiaEl-Rifai, WaelElonen, ErkkiLarramendy, Marcelo LuisRuutu, TapaniKnuutila, SakariBiologíaCiencias MédicasCGHrefractory AML5q; 7q12pComparative genomic hybridization (CGH) was used to detect changes in DNA copy number in 25 cases of refractory acute myeloid leukemia (AML). CGH detected changes in DNA copy number in nine AML (36%). Losses (82%) were more frequent than gains (18%). No high-level amplifications were detected in any of the cases. Losses involved minimal overlapping regions at 5q14q32, 7q31.2q32 and 12p12. The most frequent gain was detected at 8q. CGH gave normal results in all cases with a normal karyotype or a translocation as the sole aberration. The absence of high-level DNA copy gains suggests that, in contrast to other malignancies, gene amplification is not an important mechanism for drug resistance in AML. In addition to 5q and 7q, known to be associated with disease refractoriness, 12p may be another region related to poor prognosis.Facultad de Ciencias Naturales y Museo1997info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf958-963http://sedici.unlp.edu.ar/handle/10915/132500enginfo:eu-repo/semantics/altIdentifier/issn/0887-6924info:eu-repo/semantics/altIdentifier/issn/1476-5551info:eu-repo/semantics/altIdentifier/doi/10.1038/sj.leu.2400706info:eu-repo/semantics/altIdentifier/pmid/9204975info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:13:07Zoai:sedici.unlp.edu.ar:10915/132500Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:13:07.305SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
spellingShingle Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
El-Rifai, Wael
Biología
Ciencias Médicas
CGH
refractory AML
5q; 7q
12p
title_short Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_full Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_fullStr Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_full_unstemmed Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_sort Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
dc.creator.none.fl_str_mv El-Rifai, Wael
Elonen, Erkki
Larramendy, Marcelo Luis
Ruutu, Tapani
Knuutila, Sakari
author El-Rifai, Wael
author_facet El-Rifai, Wael
Elonen, Erkki
Larramendy, Marcelo Luis
Ruutu, Tapani
Knuutila, Sakari
author_role author
author2 Elonen, Erkki
Larramendy, Marcelo Luis
Ruutu, Tapani
Knuutila, Sakari
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biología
Ciencias Médicas
CGH
refractory AML
5q; 7q
12p
topic Biología
Ciencias Médicas
CGH
refractory AML
5q; 7q
12p
dc.description.none.fl_txt_mv Comparative genomic hybridization (CGH) was used to detect changes in DNA copy number in 25 cases of refractory acute myeloid leukemia (AML). CGH detected changes in DNA copy number in nine AML (36%). Losses (82%) were more frequent than gains (18%). No high-level amplifications were detected in any of the cases. Losses involved minimal overlapping regions at 5q14q32, 7q31.2q32 and 12p12. The most frequent gain was detected at 8q. CGH gave normal results in all cases with a normal karyotype or a translocation as the sole aberration. The absence of high-level DNA copy gains suggests that, in contrast to other malignancies, gene amplification is not an important mechanism for drug resistance in AML. In addition to 5q and 7q, known to be associated with disease refractoriness, 12p may be another region related to poor prognosis.
Facultad de Ciencias Naturales y Museo
description Comparative genomic hybridization (CGH) was used to detect changes in DNA copy number in 25 cases of refractory acute myeloid leukemia (AML). CGH detected changes in DNA copy number in nine AML (36%). Losses (82%) were more frequent than gains (18%). No high-level amplifications were detected in any of the cases. Losses involved minimal overlapping regions at 5q14q32, 7q31.2q32 and 12p12. The most frequent gain was detected at 8q. CGH gave normal results in all cases with a normal karyotype or a translocation as the sole aberration. The absence of high-level DNA copy gains suggests that, in contrast to other malignancies, gene amplification is not an important mechanism for drug resistance in AML. In addition to 5q and 7q, known to be associated with disease refractoriness, 12p may be another region related to poor prognosis.
publishDate 1997
dc.date.none.fl_str_mv 1997
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/132500
url http://sedici.unlp.edu.ar/handle/10915/132500
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0887-6924
info:eu-repo/semantics/altIdentifier/issn/1476-5551
info:eu-repo/semantics/altIdentifier/doi/10.1038/sj.leu.2400706
info:eu-repo/semantics/altIdentifier/pmid/9204975
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
958-963
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1846783498887626752
score 12.982451

Publicaciones similares