Effect of vanadium compounds on acid phosphatase activity

Autores
Vescina, Cecilia M.; Sálice, Viviana C.; Cortizo, Ana María; Etcheverry, Susana B.
Año de publicación
1996
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The direct effect of different vanadium compounds on acid phosphatase (ACP) activity was investigated. Vanadate and vanadyl but not pervanadate inhibited the wheat germ ACP activity. These vanadium derivatives did not alter the fibroblast Swiss 3T3 soluble fraction ACP activity. Using inhibitors of tyrosine phosphatases (PTPases), the wheat germ ACP was partially characterized as a PTPase. This study suggests that the inhibitory ability of different vanadium derivatives to modulate ACP activity seems to depend on the geometry around the vanadium atom more than on the oxidation state. Our results indicate a correlation between the PTPase activity and the sensitivity to vanadate and vanadyl cation.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Química
Vanadio
vanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effects
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/76255
Acceder
id SEDICI_280253e51edbd7575c7a209642d74e5c
oai_identifier_str oai:sedici.unlp.edu.ar:10915/76255
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Effect of vanadium compounds on acid phosphatase activityVescina, Cecilia M.Sálice, Viviana C.Cortizo, Ana MaríaEtcheverry, Susana B.Ciencias ExactasQuímicaVanadiovanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effectsThe direct effect of different vanadium compounds on acid phosphatase (ACP) activity was investigated. Vanadate and vanadyl but not pervanadate inhibited the wheat germ ACP activity. These vanadium derivatives did not alter the fibroblast Swiss 3T3 soluble fraction ACP activity. Using inhibitors of tyrosine phosphatases (PTPases), the wheat germ ACP was partially characterized as a PTPase. This study suggests that the inhibitory ability of different vanadium derivatives to modulate ACP activity seems to depend on the geometry around the vanadium atom more than on the oxidation state. Our results indicate a correlation between the PTPase activity and the sensitivity to vanadate and vanadyl cation.Facultad de Ciencias Exactas1996info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf185-191http://sedici.unlp.edu.ar/handle/10915/76255enginfo:eu-repo/semantics/altIdentifier/issn/0163-4984info:eu-repo/semantics/altIdentifier/hdl/11746/4413info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:13:25Zoai:sedici.unlp.edu.ar:10915/76255Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:13:25.78SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of vanadium compounds on acid phosphatase activity
title Effect of vanadium compounds on acid phosphatase activity
spellingShingle Effect of vanadium compounds on acid phosphatase activity
Vescina, Cecilia M.
Ciencias Exactas
Química
Vanadio
vanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effects
title_short Effect of vanadium compounds on acid phosphatase activity
title_full Effect of vanadium compounds on acid phosphatase activity
title_fullStr Effect of vanadium compounds on acid phosphatase activity
title_full_unstemmed Effect of vanadium compounds on acid phosphatase activity
title_sort Effect of vanadium compounds on acid phosphatase activity
dc.creator.none.fl_str_mv Vescina, Cecilia M.
Sálice, Viviana C.
Cortizo, Ana María
Etcheverry, Susana B.
author Vescina, Cecilia M.
author_facet Vescina, Cecilia M.
Sálice, Viviana C.
Cortizo, Ana María
Etcheverry, Susana B.
author_role author
author2 Sálice, Viviana C.
Cortizo, Ana María
Etcheverry, Susana B.
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Vanadio
vanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effects
topic Ciencias Exactas
Química
Vanadio
vanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effects
dc.description.none.fl_txt_mv The direct effect of different vanadium compounds on acid phosphatase (ACP) activity was investigated. Vanadate and vanadyl but not pervanadate inhibited the wheat germ ACP activity. These vanadium derivatives did not alter the fibroblast Swiss 3T3 soluble fraction ACP activity. Using inhibitors of tyrosine phosphatases (PTPases), the wheat germ ACP was partially characterized as a PTPase. This study suggests that the inhibitory ability of different vanadium derivatives to modulate ACP activity seems to depend on the geometry around the vanadium atom more than on the oxidation state. Our results indicate a correlation between the PTPase activity and the sensitivity to vanadate and vanadyl cation.
Facultad de Ciencias Exactas
description The direct effect of different vanadium compounds on acid phosphatase (ACP) activity was investigated. Vanadate and vanadyl but not pervanadate inhibited the wheat germ ACP activity. These vanadium derivatives did not alter the fibroblast Swiss 3T3 soluble fraction ACP activity. Using inhibitors of tyrosine phosphatases (PTPases), the wheat germ ACP was partially characterized as a PTPase. This study suggests that the inhibitory ability of different vanadium derivatives to modulate ACP activity seems to depend on the geometry around the vanadium atom more than on the oxidation state. Our results indicate a correlation between the PTPase activity and the sensitivity to vanadate and vanadyl cation.
publishDate 1996
dc.date.none.fl_str_mv 1996
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/76255
url http://sedici.unlp.edu.ar/handle/10915/76255
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0163-4984
info:eu-repo/semantics/altIdentifier/hdl/11746/4413
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
185-191
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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