Systems biology approach to model the life cycle of Trypanosoma cruzi

Autores
Carrea, Alejandra; Diambra, Luis Aníbal
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi's life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. In the resulting network architecture we identified a small subnetwork, formed by seven interconnected nodes, that controls the parasite's life cycle. The present approach could be useful for better understanding other single cell organisms with multiple developmental stages.
Revisión disponible en http://sedici.unlp.edu.ar/handle/10915/87345
Centro Regional de Estudios Genómicos
Materia
Biología
Trypanosoma cruzi
Parasites
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/86040

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spelling Systems biology approach to model the life cycle of Trypanosoma cruziCarrea, AlejandraDiambra, Luis AníbalBiologíaTrypanosoma cruziParasitesDue to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi's life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. In the resulting network architecture we identified a small subnetwork, formed by seven interconnected nodes, that controls the parasite's life cycle. The present approach could be useful for better understanding other single cell organisms with multiple developmental stages.Revisión disponible en http://sedici.unlp.edu.ar/handle/10915/87345Centro Regional de Estudios Genómicos2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/86040enginfo:eu-repo/semantics/altIdentifier/issn/1932-6203info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0146947info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:49Zoai:sedici.unlp.edu.ar:10915/86040Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:49.579SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Systems biology approach to model the life cycle of Trypanosoma cruzi
title Systems biology approach to model the life cycle of Trypanosoma cruzi
spellingShingle Systems biology approach to model the life cycle of Trypanosoma cruzi
Carrea, Alejandra
Biología
Trypanosoma cruzi
Parasites
title_short Systems biology approach to model the life cycle of Trypanosoma cruzi
title_full Systems biology approach to model the life cycle of Trypanosoma cruzi
title_fullStr Systems biology approach to model the life cycle of Trypanosoma cruzi
title_full_unstemmed Systems biology approach to model the life cycle of Trypanosoma cruzi
title_sort Systems biology approach to model the life cycle of Trypanosoma cruzi
dc.creator.none.fl_str_mv Carrea, Alejandra
Diambra, Luis Aníbal
author Carrea, Alejandra
author_facet Carrea, Alejandra
Diambra, Luis Aníbal
author_role author
author2 Diambra, Luis Aníbal
author2_role author
dc.subject.none.fl_str_mv Biología
Trypanosoma cruzi
Parasites
topic Biología
Trypanosoma cruzi
Parasites
dc.description.none.fl_txt_mv Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi's life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. In the resulting network architecture we identified a small subnetwork, formed by seven interconnected nodes, that controls the parasite's life cycle. The present approach could be useful for better understanding other single cell organisms with multiple developmental stages.
Revisión disponible en http://sedici.unlp.edu.ar/handle/10915/87345
Centro Regional de Estudios Genómicos
description Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi's life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. In the resulting network architecture we identified a small subnetwork, formed by seven interconnected nodes, that controls the parasite's life cycle. The present approach could be useful for better understanding other single cell organisms with multiple developmental stages.
publishDate 2016
dc.date.none.fl_str_mv 2016
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dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0146947
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
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Creative Commons Attribution 4.0 International (CC BY 4.0)
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