Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice

Autores
Zanuzzi, Carolina Natalia; Scrochi, Mariela Rita; Fuentealba, Nadia Analía; Nishida, Fabián; Portiansky, Enrique Leo; Muglia, Cecilia Isabel; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo; Galosi, Cecilia Mónica
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.
Facultad de Ciencias Veterinarias
Laboratorio de Investigaciones del Sistema Inmune
Materia
Veterinaria
Safety Index
Average Weight Gain
RK13 Cell
Equid Herpesvirus
Muench Method
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/146511
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/146511
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c miceZanuzzi, Carolina NataliaScrochi, Mariela RitaFuentealba, Nadia AnalíaNishida, FabiánPortiansky, Enrique LeoMuglia, Cecilia IsabelGimeno, Eduardo JuanBarbeito, Claudio GustavoGalosi, Cecilia MónicaVeterinariaSafety IndexAverage Weight GainRK13 CellEquid HerpesvirusMuench MethodHere, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.Facultad de Ciencias VeterinariasLaboratorio de Investigaciones del Sistema Inmune2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf141-145http://sedici.unlp.edu.ar/handle/10915/146511enginfo:eu-repo/semantics/altIdentifier/issn/1432-8798info:eu-repo/semantics/altIdentifier/issn/0304-8608info:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-013-1782-8info:eu-repo/semantics/altIdentifier/pmid/23851654info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:19Zoai:sedici.unlp.edu.ar:10915/146511Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:19.953SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
title Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
spellingShingle Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
Zanuzzi, Carolina Natalia
Veterinaria
Safety Index
Average Weight Gain
RK13 Cell
Equid Herpesvirus
Muench Method
title_short Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
title_full Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
title_fullStr Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
title_full_unstemmed Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
title_sort Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
dc.creator.none.fl_str_mv Zanuzzi, Carolina Natalia
Scrochi, Mariela Rita
Fuentealba, Nadia Analía
Nishida, Fabián
Portiansky, Enrique Leo
Muglia, Cecilia Isabel
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
Galosi, Cecilia Mónica
author Zanuzzi, Carolina Natalia
author_facet Zanuzzi, Carolina Natalia
Scrochi, Mariela Rita
Fuentealba, Nadia Analía
Nishida, Fabián
Portiansky, Enrique Leo
Muglia, Cecilia Isabel
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
Galosi, Cecilia Mónica
author_role author
author2 Scrochi, Mariela Rita
Fuentealba, Nadia Analía
Nishida, Fabián
Portiansky, Enrique Leo
Muglia, Cecilia Isabel
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
Galosi, Cecilia Mónica
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Veterinaria
Safety Index
Average Weight Gain
RK13 Cell
Equid Herpesvirus
Muench Method
topic Veterinaria
Safety Index
Average Weight Gain
RK13 Cell
Equid Herpesvirus
Muench Method
dc.description.none.fl_txt_mv Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.
Facultad de Ciencias Veterinarias
Laboratorio de Investigaciones del Sistema Inmune
description Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/146511
url http://sedici.unlp.edu.ar/handle/10915/146511
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1432-8798
info:eu-repo/semantics/altIdentifier/issn/0304-8608
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-013-1782-8
info:eu-repo/semantics/altIdentifier/pmid/23851654
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
141-145
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.22299

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