Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice
- Autores
- Zanuzzi, Carolina Natalia; Scrochi, Mariela Rita; Fuentealba, Nadia Analía; Nishida, Fabián; Portiansky, Enrique Leo; Muglia, Cecilia Isabel; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo; Galosi, Cecilia Mónica
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.
Facultad de Ciencias Veterinarias
Laboratorio de Investigaciones del Sistema Inmune - Materia
-
Veterinaria
Safety Index
Average Weight Gain
RK13 Cell
Equid Herpesvirus
Muench Method - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/146511
Ver los metadatos del registro completo
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Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c miceZanuzzi, Carolina NataliaScrochi, Mariela RitaFuentealba, Nadia AnalíaNishida, FabiánPortiansky, Enrique LeoMuglia, Cecilia IsabelGimeno, Eduardo JuanBarbeito, Claudio GustavoGalosi, Cecilia MónicaVeterinariaSafety IndexAverage Weight GainRK13 CellEquid HerpesvirusMuench MethodHere, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.Facultad de Ciencias VeterinariasLaboratorio de Investigaciones del Sistema Inmune2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf141-145http://sedici.unlp.edu.ar/handle/10915/146511enginfo:eu-repo/semantics/altIdentifier/issn/1432-8798info:eu-repo/semantics/altIdentifier/issn/0304-8608info:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-013-1782-8info:eu-repo/semantics/altIdentifier/pmid/23851654info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:19Zoai:sedici.unlp.edu.ar:10915/146511Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:19.953SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice |
title |
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice |
spellingShingle |
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice Zanuzzi, Carolina Natalia Veterinaria Safety Index Average Weight Gain RK13 Cell Equid Herpesvirus Muench Method |
title_short |
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice |
title_full |
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice |
title_fullStr |
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice |
title_full_unstemmed |
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice |
title_sort |
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice |
dc.creator.none.fl_str_mv |
Zanuzzi, Carolina Natalia Scrochi, Mariela Rita Fuentealba, Nadia Analía Nishida, Fabián Portiansky, Enrique Leo Muglia, Cecilia Isabel Gimeno, Eduardo Juan Barbeito, Claudio Gustavo Galosi, Cecilia Mónica |
author |
Zanuzzi, Carolina Natalia |
author_facet |
Zanuzzi, Carolina Natalia Scrochi, Mariela Rita Fuentealba, Nadia Analía Nishida, Fabián Portiansky, Enrique Leo Muglia, Cecilia Isabel Gimeno, Eduardo Juan Barbeito, Claudio Gustavo Galosi, Cecilia Mónica |
author_role |
author |
author2 |
Scrochi, Mariela Rita Fuentealba, Nadia Analía Nishida, Fabián Portiansky, Enrique Leo Muglia, Cecilia Isabel Gimeno, Eduardo Juan Barbeito, Claudio Gustavo Galosi, Cecilia Mónica |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Veterinaria Safety Index Average Weight Gain RK13 Cell Equid Herpesvirus Muench Method |
topic |
Veterinaria Safety Index Average Weight Gain RK13 Cell Equid Herpesvirus Muench Method |
dc.description.none.fl_txt_mv |
Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions. Facultad de Ciencias Veterinarias Laboratorio de Investigaciones del Sistema Inmune |
description |
Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/146511 |
url |
http://sedici.unlp.edu.ar/handle/10915/146511 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 141-145 |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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