The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

Autores
Vittone, Leticia Beatriz; Chiappe, Liliana Eusebia; Argel, María Isabel; Cingolani, Horacio Eugenio; Chiappe de Cingolani, Gladys Ethel
Año de publicación
1980
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.
Centro de Investigaciones Cardiovasculares
Materia
Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/139565
Acceder
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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The mechanical and biochemical effects of pentoxifylline on the perfused rat heartVittone, Leticia BeatrizChiappe, Liliana EusebiaArgel, María IsabelCingolani, Horacio EugenioChiappe de Cingolani, Gladys EthelMedicinaNucleotideProtein KinaseKinase ActivityMaximum RatePhosphodiesterasePerfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.Centro de Investigaciones Cardiovasculares1980-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1088-1090http://sedici.unlp.edu.ar/handle/10915/139565enginfo:eu-repo/semantics/altIdentifier/issn/0014-4754info:eu-repo/semantics/altIdentifier/issn/1420-9071info:eu-repo/semantics/altIdentifier/issn/1420-682xinfo:eu-repo/semantics/altIdentifier/doi/10.1007/bf01965986info:eu-repo/semantics/altIdentifier/pmid/6252042info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:02Zoai:sedici.unlp.edu.ar:10915/139565Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:02.464SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
spellingShingle The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
Vittone, Leticia Beatriz
Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
title_short The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_full The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_fullStr The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_full_unstemmed The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_sort The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
dc.creator.none.fl_str_mv Vittone, Leticia Beatriz
Chiappe, Liliana Eusebia
Argel, María Isabel
Cingolani, Horacio Eugenio
Chiappe de Cingolani, Gladys Ethel
author Vittone, Leticia Beatriz
author_facet Vittone, Leticia Beatriz
Chiappe, Liliana Eusebia
Argel, María Isabel
Cingolani, Horacio Eugenio
Chiappe de Cingolani, Gladys Ethel
author_role author
author2 Chiappe, Liliana Eusebia
Argel, María Isabel
Cingolani, Horacio Eugenio
Chiappe de Cingolani, Gladys Ethel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
topic Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
dc.description.none.fl_txt_mv Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.
Centro de Investigaciones Cardiovasculares
description Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.
publishDate 1980
dc.date.none.fl_str_mv 1980-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/139565
url http://sedici.unlp.edu.ar/handle/10915/139565
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0014-4754
info:eu-repo/semantics/altIdentifier/issn/1420-9071
info:eu-repo/semantics/altIdentifier/issn/1420-682x
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf01965986
info:eu-repo/semantics/altIdentifier/pmid/6252042
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1088-1090
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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