Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle

Autores
Venosa, Roque
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is well established that hypotonicity generates a marked and unexpected increase in active Na+ efflux in frog muscle fibers as well as in other cells like cardiac myocytes, astrocytes, brain synaptosomes and renal cells. The effect of hypotonicity on the electrical activity of skeletal muscle related to Na+ and K+ voltage-gated channels, however, has not been specifically addressed. The results of the present investigation show that the changes in resting and action potentials produced by hypotonicity can be fully explained by the reduction of intracellular [Na+] and [K+] due to the increase in cellular water content.
Centro de Investigaciones Cardiovasculares
Materia
Ciencias Médicas
Hypotonicity
Membrane potentials
Muscle
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/83952
Acceder
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscleVenosa, RoqueCiencias MédicasHypotonicityMembrane potentialsMuscleIt is well established that hypotonicity generates a marked and unexpected increase in active Na+ efflux in frog muscle fibers as well as in other cells like cardiac myocytes, astrocytes, brain synaptosomes and renal cells. The effect of hypotonicity on the electrical activity of skeletal muscle related to Na+ and K+ voltage-gated channels, however, has not been specifically addressed. The results of the present investigation show that the changes in resting and action potentials produced by hypotonicity can be fully explained by the reduction of intracellular [Na+] and [K+] due to the increase in cellular water content.Centro de Investigaciones Cardiovasculares2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf858-861http://sedici.unlp.edu.ar/handle/10915/83952enginfo:eu-repo/semantics/altIdentifier/issn/0022-0949info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.051961info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:10Zoai:sedici.unlp.edu.ar:10915/83952Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:10.327SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle
title Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle
spellingShingle Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle
Venosa, Roque
Ciencias Médicas
Hypotonicity
Membrane potentials
Muscle
title_short Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle
title_full Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle
title_fullStr Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle
title_full_unstemmed Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle
title_sort Resting and action potentials under hypotonic conditions, unlike Na+ pump activity, depend only on the alteration of intracellular [Na+] and [K+] in frog skeletal muscle
dc.creator.none.fl_str_mv Venosa, Roque
author Venosa, Roque
author_facet Venosa, Roque
author_role author
dc.subject.none.fl_str_mv Ciencias Médicas
Hypotonicity
Membrane potentials
Muscle
topic Ciencias Médicas
Hypotonicity
Membrane potentials
Muscle
dc.description.none.fl_txt_mv It is well established that hypotonicity generates a marked and unexpected increase in active Na+ efflux in frog muscle fibers as well as in other cells like cardiac myocytes, astrocytes, brain synaptosomes and renal cells. The effect of hypotonicity on the electrical activity of skeletal muscle related to Na+ and K+ voltage-gated channels, however, has not been specifically addressed. The results of the present investigation show that the changes in resting and action potentials produced by hypotonicity can be fully explained by the reduction of intracellular [Na+] and [K+] due to the increase in cellular water content.
Centro de Investigaciones Cardiovasculares
description It is well established that hypotonicity generates a marked and unexpected increase in active Na+ efflux in frog muscle fibers as well as in other cells like cardiac myocytes, astrocytes, brain synaptosomes and renal cells. The effect of hypotonicity on the electrical activity of skeletal muscle related to Na+ and K+ voltage-gated channels, however, has not been specifically addressed. The results of the present investigation show that the changes in resting and action potentials produced by hypotonicity can be fully explained by the reduction of intracellular [Na+] and [K+] due to the increase in cellular water content.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/83952
url http://sedici.unlp.edu.ar/handle/10915/83952
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0022-0949
info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.051961
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
858-861
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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