Impact of A118G polymorphism on the Mu opioid receptor function in pain

Autores
López Soto, Eduardo Javier; Agosti, Francina; Catanesi, Cecilia Inés; Raingo, Jesica
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by OPRM1 gene and its messenger RNA suffers extensible modifications by alternative splicing and single nucleotide polymorphisms (SNPs). A118G (N40D) is the most frequent encoding MOR SNP in humans. In this review we discuss the impact of this polymorphism at molecular, cellular and clinical levels. Since some SNPs are unequally distributed among human populations, we also discuss the utility of A118G as an ethnicity marker among worldwide human populations. As an example, we evaluate A118G frequency in an Argentinean humanpopulation and compare it with worldwide frequencies extracted from HapMap database.
Instituto Multidisciplinario de Biología Celular
Materia
Medicina
Mu-opioid receptor
A118g polymorphism
N40d polymorphism
Voltage-gated calcium channel
Population studies
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/98211
Acceder
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Impact of A118G polymorphism on the Mu opioid receptor function in painLópez Soto, Eduardo JavierAgosti, FrancinaCatanesi, Cecilia InésRaingo, JesicaMedicinaMu-opioid receptorA118g polymorphismN40d polymorphismVoltage-gated calcium channelPopulation studiesMu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by <i>OPRM1</i> gene and its messenger RNA suffers extensible modifications by alternative splicing and single nucleotide polymorphisms (SNPs). A118G (N40D) is the most frequent encoding MOR SNP in humans. In this review we discuss the impact of this polymorphism at molecular, cellular and clinical levels. Since some SNPs are unequally distributed among human populations, we also discuss the utility of A118G as an ethnicity marker among worldwide human populations. As an example, we evaluate A118G frequency in an Argentinean humanpopulation and compare it with worldwide frequencies extracted from HapMap database.Instituto Multidisciplinario de Biología Celular2013-07-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1-6http://sedici.unlp.edu.ar/handle/10915/98211enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/85028info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/impact-of-ag-polymorphism-on-the-mu-opioid-receptor-function-in-pain-2167-0846.1000119.php?aid=15830info:eu-repo/semantics/altIdentifier/issn/2167-0846info:eu-repo/semantics/altIdentifier/doi/10.4172/2167-0846.1000119info:eu-repo/semantics/altIdentifier/hdl/11336/85028info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:01:21Zoai:sedici.unlp.edu.ar:10915/98211Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:01:21.493SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Impact of A118G polymorphism on the Mu opioid receptor function in pain
title Impact of A118G polymorphism on the Mu opioid receptor function in pain
spellingShingle Impact of A118G polymorphism on the Mu opioid receptor function in pain
López Soto, Eduardo Javier
Medicina
Mu-opioid receptor
A118g polymorphism
N40d polymorphism
Voltage-gated calcium channel
Population studies
title_short Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_full Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_fullStr Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_full_unstemmed Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_sort Impact of A118G polymorphism on the Mu opioid receptor function in pain
dc.creator.none.fl_str_mv López Soto, Eduardo Javier
Agosti, Francina
Catanesi, Cecilia Inés
Raingo, Jesica
author López Soto, Eduardo Javier
author_facet López Soto, Eduardo Javier
Agosti, Francina
Catanesi, Cecilia Inés
Raingo, Jesica
author_role author
author2 Agosti, Francina
Catanesi, Cecilia Inés
Raingo, Jesica
author2_role author
author
author
dc.subject.none.fl_str_mv Medicina
Mu-opioid receptor
A118g polymorphism
N40d polymorphism
Voltage-gated calcium channel
Population studies
topic Medicina
Mu-opioid receptor
A118g polymorphism
N40d polymorphism
Voltage-gated calcium channel
Population studies
dc.description.none.fl_txt_mv Mu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by <i>OPRM1</i> gene and its messenger RNA suffers extensible modifications by alternative splicing and single nucleotide polymorphisms (SNPs). A118G (N40D) is the most frequent encoding MOR SNP in humans. In this review we discuss the impact of this polymorphism at molecular, cellular and clinical levels. Since some SNPs are unequally distributed among human populations, we also discuss the utility of A118G as an ethnicity marker among worldwide human populations. As an example, we evaluate A118G frequency in an Argentinean humanpopulation and compare it with worldwide frequencies extracted from HapMap database.
Instituto Multidisciplinario de Biología Celular
description Mu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by <i>OPRM1</i> gene and its messenger RNA suffers extensible modifications by alternative splicing and single nucleotide polymorphisms (SNPs). A118G (N40D) is the most frequent encoding MOR SNP in humans. In this review we discuss the impact of this polymorphism at molecular, cellular and clinical levels. Since some SNPs are unequally distributed among human populations, we also discuss the utility of A118G as an ethnicity marker among worldwide human populations. As an example, we evaluate A118G frequency in an Argentinean humanpopulation and compare it with worldwide frequencies extracted from HapMap database.
publishDate 2013
dc.date.none.fl_str_mv 2013-07-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/98211
url http://sedici.unlp.edu.ar/handle/10915/98211
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/85028
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/impact-of-ag-polymorphism-on-the-mu-opioid-receptor-function-in-pain-2167-0846.1000119.php?aid=15830
info:eu-repo/semantics/altIdentifier/issn/2167-0846
info:eu-repo/semantics/altIdentifier/doi/10.4172/2167-0846.1000119
info:eu-repo/semantics/altIdentifier/hdl/11336/85028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
1-6
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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