Metastatic dissemination with special emphasis on breast cancer cutaneous metastases
- Autores
- Luna, Amalia; Segal-Eiras, Amada; Croce, María Virginia
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- reseña artículo
- Estado
- versión publicada
- Descripción
- Metastatic development is a complex, multistage process involving modulation of cell phenotype, cell migration, and dynamic homeotypic as well as heterotypic cell-cell interactions. In breast cancer, MUC1 mucin has been emerging as a key molecule involved in metastasis. MUC1 is a large transmembrane glycoprotein expressed by mammary normal epithelial cells but it is overexpressed and underglycosylated in cancer cells. Cutaneous metastasis is a neoplastic lesion localized at the dermis or subcutaneous cellular tissue, which is not contiguous to the primary tumor, with an overall incidence of 5.3%. The most common tumor to metastasize to the skin is breast cancer with an incidence of 24%. We present a minireview on metastatic dissemination with special emphasis on breast cancer cutaneous metastases and the role that MUC1 plays on it.
Sociedad Argentina de Fisiología - Materia
-
Ciencias Médicas
metastases
cutaneous metastases
breast cancer
MUC1 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/127763
Ver los metadatos del registro completo
| id |
SEDICI_055ca04e4d70235e176e952c37510c69 |
|---|---|
| oai_identifier_str |
oai:sedici.unlp.edu.ar:10915/127763 |
| network_acronym_str |
SEDICI |
| repository_id_str |
1329 |
| network_name_str |
SEDICI (UNLP) |
| spelling |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastasesLuna, AmaliaSegal-Eiras, AmadaCroce, María VirginiaCiencias Médicasmetastasescutaneous metastasesbreast cancerMUC1Metastatic development is a complex, multistage process involving modulation of cell phenotype, cell migration, and dynamic homeotypic as well as heterotypic cell-cell interactions. In breast cancer, MUC1 mucin has been emerging as a key molecule involved in metastasis. MUC1 is a large transmembrane glycoprotein expressed by mammary normal epithelial cells but it is overexpressed and underglycosylated in cancer cells. Cutaneous metastasis is a neoplastic lesion localized at the dermis or subcutaneous cellular tissue, which is not contiguous to the primary tumor, with an overall incidence of 5.3%. The most common tumor to metastasize to the skin is breast cancer with an incidence of 24%. We present a minireview on metastatic dissemination with special emphasis on breast cancer cutaneous metastases and the role that MUC1 plays on it.Sociedad Argentina de Fisiología2015info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf23-32http://sedici.unlp.edu.ar/handle/10915/127763enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/wp-content/uploads/2022/07/vol_8_3.pdfinfo:eu-repo/semantics/altIdentifier/issn/1669-5402info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-11-05T13:10:15Zoai:sedici.unlp.edu.ar:10915/127763Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-11-05 13:10:15.992SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases |
| title |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases |
| spellingShingle |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases Luna, Amalia Ciencias Médicas metastases cutaneous metastases breast cancer MUC1 |
| title_short |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases |
| title_full |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases |
| title_fullStr |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases |
| title_full_unstemmed |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases |
| title_sort |
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases |
| dc.creator.none.fl_str_mv |
Luna, Amalia Segal-Eiras, Amada Croce, María Virginia |
| author |
Luna, Amalia |
| author_facet |
Luna, Amalia Segal-Eiras, Amada Croce, María Virginia |
| author_role |
author |
| author2 |
Segal-Eiras, Amada Croce, María Virginia |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Ciencias Médicas metastases cutaneous metastases breast cancer MUC1 |
| topic |
Ciencias Médicas metastases cutaneous metastases breast cancer MUC1 |
| dc.description.none.fl_txt_mv |
Metastatic development is a complex, multistage process involving modulation of cell phenotype, cell migration, and dynamic homeotypic as well as heterotypic cell-cell interactions. In breast cancer, MUC1 mucin has been emerging as a key molecule involved in metastasis. MUC1 is a large transmembrane glycoprotein expressed by mammary normal epithelial cells but it is overexpressed and underglycosylated in cancer cells. Cutaneous metastasis is a neoplastic lesion localized at the dermis or subcutaneous cellular tissue, which is not contiguous to the primary tumor, with an overall incidence of 5.3%. The most common tumor to metastasize to the skin is breast cancer with an incidence of 24%. We present a minireview on metastatic dissemination with special emphasis on breast cancer cutaneous metastases and the role that MUC1 plays on it. Sociedad Argentina de Fisiología |
| description |
Metastatic development is a complex, multistage process involving modulation of cell phenotype, cell migration, and dynamic homeotypic as well as heterotypic cell-cell interactions. In breast cancer, MUC1 mucin has been emerging as a key molecule involved in metastasis. MUC1 is a large transmembrane glycoprotein expressed by mammary normal epithelial cells but it is overexpressed and underglycosylated in cancer cells. Cutaneous metastasis is a neoplastic lesion localized at the dermis or subcutaneous cellular tissue, which is not contiguous to the primary tumor, with an overall incidence of 5.3%. The most common tumor to metastasize to the skin is breast cancer with an incidence of 24%. We present a minireview on metastatic dissemination with special emphasis on breast cancer cutaneous metastases and the role that MUC1 plays on it. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Revision http://purl.org/coar/resource_type/c_dcae04bc info:ar-repo/semantics/resenaArticulo |
| format |
review |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/127763 |
| url |
http://sedici.unlp.edu.ar/handle/10915/127763 |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/wp-content/uploads/2022/07/vol_8_3.pdf info:eu-repo/semantics/altIdentifier/issn/1669-5402 info:eu-repo/semantics/altIdentifier/issn/1669-5410 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
| dc.format.none.fl_str_mv |
application/pdf 23-32 |
| dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
| reponame_str |
SEDICI (UNLP) |
| collection |
SEDICI (UNLP) |
| instname_str |
Universidad Nacional de La Plata |
| instacron_str |
UNLP |
| institution |
UNLP |
| repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
| repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
| _version_ |
1847978748476915712 |
| score |
13.084122 |