Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients

Autores
Echeverría, María Gabriela; Martí, Gerardo Aníbal; Susevich, María Laura; Rabinovich, Jorge Eduardo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake. Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.
La lista completa de autores que integran el documento puede consultarse en el archivo.
Facultad de Ciencias Veterinarias
Centro de Estudios Parasitológicos y de Vectores
Facultad de Ciencias Naturales y Museo
Materia
Ciencias Naturales
Ciencias Veterinarias
Ciencias Médicas
Biological control
Chagas disease
Dicistroviridae
Mathematical model
Passive viral exposure
Triatoma virus
Triatomines
Trypanosoma cruzi
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/86187
Acceder
id SEDICI_05180adc3bd6053be5483795858e3e71
oai_identifier_str oai:sedici.unlp.edu.ar:10915/86187
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patientsEcheverría, María GabrielaMartí, Gerardo AníbalSusevich, María LauraRabinovich, Jorge EduardoCiencias NaturalesCiencias VeterinariasCiencias MédicasBiological controlChagas diseaseDicistroviridaeMathematical modelPassive viral exposureTriatoma virusTriatominesTrypanosoma cruziBackground: Chagas disease is caused by <i>Trypanosoma cruzi</i>, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with <i>T. cruzi</i>, the infected insects release the virus when defecating during or after blood uptake. Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.La lista completa de autores que integran el documento puede consultarse en el archivo.Facultad de Ciencias VeterinariasCentro de Estudios Parasitológicos y de VectoresFacultad de Ciencias Naturales y Museo2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/86187enginfo:eu-repo/semantics/altIdentifier/issn/1756-3305info:eu-repo/semantics/altIdentifier/doi/10.1186/s13071-015-0632-9info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:08:51Zoai:sedici.unlp.edu.ar:10915/86187Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:08:51.569SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
spellingShingle Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
Echeverría, María Gabriela
Ciencias Naturales
Ciencias Veterinarias
Ciencias Médicas
Biological control
Chagas disease
Dicistroviridae
Mathematical model
Passive viral exposure
Triatoma virus
Triatomines
Trypanosoma cruzi
title_short Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_full Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_fullStr Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_full_unstemmed Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_sort Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
dc.creator.none.fl_str_mv Echeverría, María Gabriela
Martí, Gerardo Aníbal
Susevich, María Laura
Rabinovich, Jorge Eduardo
author Echeverría, María Gabriela
author_facet Echeverría, María Gabriela
Martí, Gerardo Aníbal
Susevich, María Laura
Rabinovich, Jorge Eduardo
author_role author
author2 Martí, Gerardo Aníbal
Susevich, María Laura
Rabinovich, Jorge Eduardo
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Naturales
Ciencias Veterinarias
Ciencias Médicas
Biological control
Chagas disease
Dicistroviridae
Mathematical model
Passive viral exposure
Triatoma virus
Triatomines
Trypanosoma cruzi
topic Ciencias Naturales
Ciencias Veterinarias
Ciencias Médicas
Biological control
Chagas disease
Dicistroviridae
Mathematical model
Passive viral exposure
Triatoma virus
Triatomines
Trypanosoma cruzi
dc.description.none.fl_txt_mv Background: Chagas disease is caused by <i>Trypanosoma cruzi</i>, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with <i>T. cruzi</i>, the infected insects release the virus when defecating during or after blood uptake. Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.
La lista completa de autores que integran el documento puede consultarse en el archivo.
Facultad de Ciencias Veterinarias
Centro de Estudios Parasitológicos y de Vectores
Facultad de Ciencias Naturales y Museo
description Background: Chagas disease is caused by <i>Trypanosoma cruzi</i>, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with <i>T. cruzi</i>, the infected insects release the virus when defecating during or after blood uptake. Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/86187
url http://sedici.unlp.edu.ar/handle/10915/86187
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1756-3305
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13071-015-0632-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1846064145308319744
score 13.22299

Publicaciones similares