Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas

Autores
Pezzarini, Eleonora; Rossi, María F.; Balbi, Bárbara; Monje, Adriana L.; Ocampo Alzate, Carlos; Basiglio, Cecilia Lorena; Rodenas, M.; Daniele, Stella Maris; Arriaga, Sandra Mónica María; Pelusa, Héctor Fabián
Año de publicación
2015
Idioma
español castellano
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
More than 40 formulas have been developed to estimate the glomerular filtration rate (GFR) involving creatinine concentration (Cr) as well as demographic and anthropometric variables. Modification of Diet in Renal Disease (MDRD-4) is the most recommended one. However, several studies state that Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation improves the results obtained with MDRD-4. Our aim was to compare the results of the estimated GFR (eGFR) obtained with both formulas in patients with glomerular pathology. We studied 32 individuals with glomerulopathies, age (mean±SD): 34±8 years old, 24 females (F) and 8 males (M). Cr was assessed by an automated method. Results were expressed as mean±SD. eGFR (ml/min) with CKD-EPI and MDRD-4 were 102±41 and 105±51 respectively; no significant differences were obtained between both formulas (p>0.05). Correlation coefficient between both equations was highly significant (r=0.93; p<0.0001). eGFR values were compared by sex and age. Results obtained for CKD-EPI and MDRD-4 by sex were: F: 107±38 and 111±51; M: 85±47 and 86±48, respectively. Results obtained for CKD-EPI and MDRD-4 by age were: < 34 years old: 109±41 and 111±55; ≥ 34 years old: 93±40 and 96±46, respectively. No significant differences were obtained for sex nor age (p>0.05). We conclude that both formulas could be used indistinctly as estimators of GFR in patients with glomerular pathology. For GFR values > normal values, eGFR with both equations would tend to a poorer correlation, then stratification and comparison of these values with those obtained from Cr clearance are suggested in order to determine which equation would be the best analytical predictor in patients with glomerulopathy and glomerular hyperfiltration.
Fil: Fil: Pezzarini, Eleonora. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Rossi, María F. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Fil: Rossi, María F. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Argentina
Fil: Fil: Balbi, Bárbara. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Monje, Adriana L. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Fil: Monje, Adriana L. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Argentina
Fil: Fil: Ocampo Alzate, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Basiglio, Cecilia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Basiglio, Cecilia L. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina
Fil: Fil: Rodenas, M. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Fil: Rodenas, M. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Argentina
Fil: Fil: Daniele, Stella Maris. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Arriaga, Sandra Mónica María. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Pelusa, Héctor Fabián. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Materia
CKD-EPI
MDRD-4
Glomerular Filtration Rate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
RepHipUNR (UNR)
Institución
Universidad Nacional de Rosario
OAI Identificador
oai:rephip.unr.edu.ar:2133/10215
Acceder
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oai_identifier_str oai:rephip.unr.edu.ar:2133/10215
network_acronym_str RepHipUNR
repository_id_str 1550
network_name_str RepHipUNR (UNR)
spelling Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulasUtilidad de las fórmulas CDK-EPI y MDRD-4 para estimar el índice de filtración glomerular en pacientes con patología glomerularPezzarini, EleonoraRossi, María F.Balbi, BárbaraMonje, Adriana L.Ocampo Alzate, CarlosBasiglio, Cecilia LorenaRodenas, M.Daniele, Stella MarisArriaga, Sandra Mónica MaríaPelusa, Héctor FabiánCKD-EPIMDRD-4Glomerular Filtration RateMore than 40 formulas have been developed to estimate the glomerular filtration rate (GFR) involving creatinine concentration (Cr) as well as demographic and anthropometric variables. Modification of Diet in Renal Disease (MDRD-4) is the most recommended one. However, several studies state that Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation improves the results obtained with MDRD-4. Our aim was to compare the results of the estimated GFR (eGFR) obtained with both formulas in patients with glomerular pathology. We studied 32 individuals with glomerulopathies, age (mean±SD): 34±8 years old, 24 females (F) and 8 males (M). Cr was assessed by an automated method. Results were expressed as mean±SD. eGFR (ml/min) with CKD-EPI and MDRD-4 were 102±41 and 105±51 respectively; no significant differences were obtained between both formulas (p>0.05). Correlation coefficient between both equations was highly significant (r=0.93; p<0.0001). eGFR values were compared by sex and age. Results obtained for CKD-EPI and MDRD-4 by sex were: F: 107±38 and 111±51; M: 85±47 and 86±48, respectively. Results obtained for CKD-EPI and MDRD-4 by age were: < 34 years old: 109±41 and 111±55; ≥ 34 years old: 93±40 and 96±46, respectively. No significant differences were obtained for sex nor age (p>0.05). We conclude that both formulas could be used indistinctly as estimators of GFR in patients with glomerular pathology. For GFR values > normal values, eGFR with both equations would tend to a poorer correlation, then stratification and comparison of these values with those obtained from Cr clearance are suggested in order to determine which equation would be the best analytical predictor in patients with glomerulopathy and glomerular hyperfiltration.Fil: Fil: Pezzarini, Eleonora. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; ArgentinaFil: Fil: Rossi, María F. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Fil: Rossi, María F. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; ArgentinaFil: Fil: Balbi, Bárbara. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; ArgentinaFil: Fil: Monje, Adriana L. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Fil: Monje, Adriana L. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; ArgentinaFil: Fil: Ocampo Alzate, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; ArgentinaFil: Fil: Basiglio, Cecilia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; ArgentinaFil: Fil: Basiglio, Cecilia L. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); ArgentinaFil: Fil: Rodenas, M. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Fil: Rodenas, M. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; ArgentinaFil: Fil: Daniele, Stella Maris. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; ArgentinaFil: Fil: Arriaga, Sandra Mónica María. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; ArgentinaFil: Fil: Pelusa, Héctor Fabián. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; ArgentinaInstituto de Histología y Embriología “Dr. Mario H. Burgos” (IHEM-CONICET)Sociedad Argentina de Investigación en Bioquímica y Biología Molecular2015info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/2133/10215urn:issn: 1667-5746spahttp://www.cricyt.edu.ar/biocell/vol/pdf/39_4/39_4.pdfinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/Licencia RepHipreponame:RepHipUNR (UNR)instname:Universidad Nacional de Rosario2025-09-04T09:46:18Zoai:rephip.unr.edu.ar:2133/10215instacron:UNRInstitucionalhttps://rephip.unr.edu.ar/Universidad públicaNo correspondehttps://rephip.unr.edu.ar/oai/requestrephip@unr.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:15502025-09-04 09:46:18.585RepHipUNR (UNR) - Universidad Nacional de Rosariofalse
dc.title.none.fl_str_mv Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
Utilidad de las fórmulas CDK-EPI y MDRD-4 para estimar el índice de filtración glomerular en pacientes con patología glomerular
title Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
spellingShingle Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
Pezzarini, Eleonora
CKD-EPI
MDRD-4
Glomerular Filtration Rate
title_short Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_full Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_fullStr Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_full_unstemmed Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
title_sort Estimation of the glomerular filtration rate in patients with glomerular pathology comparing CKD-EPI y MDRD-4 formulas
dc.creator.none.fl_str_mv Pezzarini, Eleonora
Rossi, María F.
Balbi, Bárbara
Monje, Adriana L.
Ocampo Alzate, Carlos
Basiglio, Cecilia Lorena
Rodenas, M.
Daniele, Stella Maris
Arriaga, Sandra Mónica María
Pelusa, Héctor Fabián
author Pezzarini, Eleonora
author_facet Pezzarini, Eleonora
Rossi, María F.
Balbi, Bárbara
Monje, Adriana L.
Ocampo Alzate, Carlos
Basiglio, Cecilia Lorena
Rodenas, M.
Daniele, Stella Maris
Arriaga, Sandra Mónica María
Pelusa, Héctor Fabián
author_role author
author2 Rossi, María F.
Balbi, Bárbara
Monje, Adriana L.
Ocampo Alzate, Carlos
Basiglio, Cecilia Lorena
Rodenas, M.
Daniele, Stella Maris
Arriaga, Sandra Mónica María
Pelusa, Héctor Fabián
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
dc.subject.none.fl_str_mv CKD-EPI
MDRD-4
Glomerular Filtration Rate
topic CKD-EPI
MDRD-4
Glomerular Filtration Rate
dc.description.none.fl_txt_mv More than 40 formulas have been developed to estimate the glomerular filtration rate (GFR) involving creatinine concentration (Cr) as well as demographic and anthropometric variables. Modification of Diet in Renal Disease (MDRD-4) is the most recommended one. However, several studies state that Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation improves the results obtained with MDRD-4. Our aim was to compare the results of the estimated GFR (eGFR) obtained with both formulas in patients with glomerular pathology. We studied 32 individuals with glomerulopathies, age (mean±SD): 34±8 years old, 24 females (F) and 8 males (M). Cr was assessed by an automated method. Results were expressed as mean±SD. eGFR (ml/min) with CKD-EPI and MDRD-4 were 102±41 and 105±51 respectively; no significant differences were obtained between both formulas (p>0.05). Correlation coefficient between both equations was highly significant (r=0.93; p<0.0001). eGFR values were compared by sex and age. Results obtained for CKD-EPI and MDRD-4 by sex were: F: 107±38 and 111±51; M: 85±47 and 86±48, respectively. Results obtained for CKD-EPI and MDRD-4 by age were: < 34 years old: 109±41 and 111±55; ≥ 34 years old: 93±40 and 96±46, respectively. No significant differences were obtained for sex nor age (p>0.05). We conclude that both formulas could be used indistinctly as estimators of GFR in patients with glomerular pathology. For GFR values > normal values, eGFR with both equations would tend to a poorer correlation, then stratification and comparison of these values with those obtained from Cr clearance are suggested in order to determine which equation would be the best analytical predictor in patients with glomerulopathy and glomerular hyperfiltration.
Fil: Fil: Pezzarini, Eleonora. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Rossi, María F. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Fil: Rossi, María F. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Argentina
Fil: Fil: Balbi, Bárbara. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Monje, Adriana L. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Fil: Monje, Adriana L. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Argentina
Fil: Fil: Ocampo Alzate, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Basiglio, Cecilia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Basiglio, Cecilia L. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina
Fil: Fil: Rodenas, M. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Fil: Rodenas, M. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Nefrología; Argentina
Fil: Fil: Daniele, Stella Maris. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Arriaga, Sandra Mónica María. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
Fil: Fil: Pelusa, Héctor Fabián. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Bioquímica Clínica; Argentina
description More than 40 formulas have been developed to estimate the glomerular filtration rate (GFR) involving creatinine concentration (Cr) as well as demographic and anthropometric variables. Modification of Diet in Renal Disease (MDRD-4) is the most recommended one. However, several studies state that Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation improves the results obtained with MDRD-4. Our aim was to compare the results of the estimated GFR (eGFR) obtained with both formulas in patients with glomerular pathology. We studied 32 individuals with glomerulopathies, age (mean±SD): 34±8 years old, 24 females (F) and 8 males (M). Cr was assessed by an automated method. Results were expressed as mean±SD. eGFR (ml/min) with CKD-EPI and MDRD-4 were 102±41 and 105±51 respectively; no significant differences were obtained between both formulas (p>0.05). Correlation coefficient between both equations was highly significant (r=0.93; p<0.0001). eGFR values were compared by sex and age. Results obtained for CKD-EPI and MDRD-4 by sex were: F: 107±38 and 111±51; M: 85±47 and 86±48, respectively. Results obtained for CKD-EPI and MDRD-4 by age were: < 34 years old: 109±41 and 111±55; ≥ 34 years old: 93±40 and 96±46, respectively. No significant differences were obtained for sex nor age (p>0.05). We conclude that both formulas could be used indistinctly as estimators of GFR in patients with glomerular pathology. For GFR values > normal values, eGFR with both equations would tend to a poorer correlation, then stratification and comparison of these values with those obtained from Cr clearance are suggested in order to determine which equation would be the best analytical predictor in patients with glomerulopathy and glomerular hyperfiltration.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject


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dc.identifier.none.fl_str_mv http://hdl.handle.net/2133/10215
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identifier_str_mv urn:issn: 1667-5746
dc.language.none.fl_str_mv spa
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dc.relation.none.fl_str_mv http://www.cricyt.edu.ar/biocell/vol/pdf/39_4/39_4.pdf
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dc.publisher.none.fl_str_mv Instituto de Histología y Embriología “Dr. Mario H. Burgos” (IHEM-CONICET)
publisher.none.fl_str_mv Instituto de Histología y Embriología “Dr. Mario H. Burgos” (IHEM-CONICET)
dc.source.none.fl_str_mv reponame:RepHipUNR (UNR)
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