Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis
- Autores
- Stoyanoff, Tania Romina; Todaro, Juan Santiago; Aguirre, María Victoria; Zimmermann, María Carla; Brandan, Nora Cristina
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Stoyanoff, Tania Romina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.
Fil: Stoyanoff, Tania Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaria Ciencia y Técnica. Centro Científico Tecnológico Nordeste; Argentina.
Fil: Todaro, Juan Santiago. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.
Fil: Todaro, Juan Santiago. Universidad Nacional del Nordeste. Secretaria General de Ciencia y Técnica; Argentina.
Fil: Aguirre, María Victoria. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.
Fil: Zimmermann, María Carla. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.
Fil: Zimmermann, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.
Fil: Brandan, Nora Cristina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.
Fil: Brandan, Nora Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.
Sepsis remains the most important cause of acute kidney injury (AKI) in critically ill patients and is an independent predictor of poor outcome. The administration of lipopolysaccharide (LPS) to animals reproduces most of the clinical features of sepsis, including AKI, a condition associated with renal cellular dysfunction and apoptosis. Erythropoietin (EPO) is a well known cytoprotective multifunctional hormone, which exerts antiinflammatory, anti-oxidant, anti-apoptotic and angiogenic effects in several tissues. The aim of this study was to evaluate the underlying mechanisms of EPO renoprotection through the expression of the EPO receptor (EPO-R) and the modulation of the intrinsic apoptotic pathway in LPS-induced AKI. Male inbred Balb/c mice were divided in four experimental groups: Control, LPS (8 mg/kg i.p.), EPO (3000 IU sc) and LPS + EPO. Assessment of renal function, histological examination, TUNEL in situ assay, immunohistochemistry and Western blottings of caspase-3, Bax, Bcl-xL, EPO-R and Cytochrome c were performed at 24 h post treatment. LPS + EPO treatment significantly improved renal function and ameliorated histopathological injury when compared to the LPS treated group. Results showed that EPO treatment attenuates renal tubular apoptosis through: (a) the overexpression of EPO-R in tubular interstitial cells, (b) the reduction of Bax/Bcl-xL ratio, (c) the inhibition Cytochrome c release into the cytosol and (d) the decrease of the active caspase-3 expression. This study suggests that EPO exerts renoprotection on an experimental model of LPS-induced AKI. EPO induced renoprotection involves an anti-apoptotic effect through the expression of EPO-R and the regulation of the mitochondrial apoptotic pathway. - Fuente
- Toxicology, 2014, vol. 318, p. 13-21.
- Materia
-
Sepsis
EPO induced renoprotection - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Universidad Nacional del Nordeste
- OAI Identificador
- oai:repositorio.unne.edu.ar:123456789/33813
Ver los metadatos del registro completo
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Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosisStoyanoff, Tania RominaTodaro, Juan SantiagoAguirre, María VictoriaZimmermann, María CarlaBrandan, Nora CristinaSepsisEPO induced renoprotectionFil: Stoyanoff, Tania Romina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.Fil: Stoyanoff, Tania Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaria Ciencia y Técnica. Centro Científico Tecnológico Nordeste; Argentina.Fil: Todaro, Juan Santiago. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.Fil: Todaro, Juan Santiago. Universidad Nacional del Nordeste. Secretaria General de Ciencia y Técnica; Argentina.Fil: Aguirre, María Victoria. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.Fil: Zimmermann, María Carla. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.Fil: Zimmermann, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.Fil: Brandan, Nora Cristina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.Fil: Brandan, Nora Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.Sepsis remains the most important cause of acute kidney injury (AKI) in critically ill patients and is an independent predictor of poor outcome. The administration of lipopolysaccharide (LPS) to animals reproduces most of the clinical features of sepsis, including AKI, a condition associated with renal cellular dysfunction and apoptosis. Erythropoietin (EPO) is a well known cytoprotective multifunctional hormone, which exerts antiinflammatory, anti-oxidant, anti-apoptotic and angiogenic effects in several tissues. The aim of this study was to evaluate the underlying mechanisms of EPO renoprotection through the expression of the EPO receptor (EPO-R) and the modulation of the intrinsic apoptotic pathway in LPS-induced AKI. Male inbred Balb/c mice were divided in four experimental groups: Control, LPS (8 mg/kg i.p.), EPO (3000 IU sc) and LPS + EPO. Assessment of renal function, histological examination, TUNEL in situ assay, immunohistochemistry and Western blottings of caspase-3, Bax, Bcl-xL, EPO-R and Cytochrome c were performed at 24 h post treatment. LPS + EPO treatment significantly improved renal function and ameliorated histopathological injury when compared to the LPS treated group. Results showed that EPO treatment attenuates renal tubular apoptosis through: (a) the overexpression of EPO-R in tubular interstitial cells, (b) the reduction of Bax/Bcl-xL ratio, (c) the inhibition Cytochrome c release into the cytosol and (d) the decrease of the active caspase-3 expression. This study suggests that EPO exerts renoprotection on an experimental model of LPS-induced AKI. EPO induced renoprotection involves an anti-apoptotic effect through the expression of EPO-R and the regulation of the mitochondrial apoptotic pathway.Elsevier Ireland Ltd2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfStoyanoff, Tania Romina, et al, 2014. Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : Involvement of mitochondria-regulated. Toxicology. Ámsterdam: Elsevier Ireland Ltd, vol. 318, p. 13-21. ISSN 0300-483X.http://repositorio.unne.edu.ar/handle/123456789/33813Toxicology, 2014, vol. 318, p. 13-21.reponame:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)instname:Universidad Nacional del Nordesteenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/Atribución-NoComercial-SinDerivadas 2.5 Argentina2025-09-29T14:29:10Zoai:repositorio.unne.edu.ar:123456789/33813instacron:UNNEInstitucionalhttp://repositorio.unne.edu.ar/Universidad públicaNo correspondehttp://repositorio.unne.edu.ar/oaiososa@bib.unne.edu.ar;sergio.alegria@unne.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:48712025-09-29 14:29:10.835Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) - Universidad Nacional del Nordestefalse |
dc.title.none.fl_str_mv |
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis |
title |
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis |
spellingShingle |
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis Stoyanoff, Tania Romina Sepsis EPO induced renoprotection |
title_short |
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis |
title_full |
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis |
title_fullStr |
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis |
title_full_unstemmed |
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis |
title_sort |
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : involvement of mitochondria-regulated apoptosis |
dc.creator.none.fl_str_mv |
Stoyanoff, Tania Romina Todaro, Juan Santiago Aguirre, María Victoria Zimmermann, María Carla Brandan, Nora Cristina |
author |
Stoyanoff, Tania Romina |
author_facet |
Stoyanoff, Tania Romina Todaro, Juan Santiago Aguirre, María Victoria Zimmermann, María Carla Brandan, Nora Cristina |
author_role |
author |
author2 |
Todaro, Juan Santiago Aguirre, María Victoria Zimmermann, María Carla Brandan, Nora Cristina |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Sepsis EPO induced renoprotection |
topic |
Sepsis EPO induced renoprotection |
dc.description.none.fl_txt_mv |
Fil: Stoyanoff, Tania Romina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Fil: Stoyanoff, Tania Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaria Ciencia y Técnica. Centro Científico Tecnológico Nordeste; Argentina. Fil: Todaro, Juan Santiago. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Fil: Todaro, Juan Santiago. Universidad Nacional del Nordeste. Secretaria General de Ciencia y Técnica; Argentina. Fil: Aguirre, María Victoria. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Fil: Zimmermann, María Carla. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Fil: Zimmermann, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina. Fil: Brandan, Nora Cristina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Fil: Brandan, Nora Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina. Sepsis remains the most important cause of acute kidney injury (AKI) in critically ill patients and is an independent predictor of poor outcome. The administration of lipopolysaccharide (LPS) to animals reproduces most of the clinical features of sepsis, including AKI, a condition associated with renal cellular dysfunction and apoptosis. Erythropoietin (EPO) is a well known cytoprotective multifunctional hormone, which exerts antiinflammatory, anti-oxidant, anti-apoptotic and angiogenic effects in several tissues. The aim of this study was to evaluate the underlying mechanisms of EPO renoprotection through the expression of the EPO receptor (EPO-R) and the modulation of the intrinsic apoptotic pathway in LPS-induced AKI. Male inbred Balb/c mice were divided in four experimental groups: Control, LPS (8 mg/kg i.p.), EPO (3000 IU sc) and LPS + EPO. Assessment of renal function, histological examination, TUNEL in situ assay, immunohistochemistry and Western blottings of caspase-3, Bax, Bcl-xL, EPO-R and Cytochrome c were performed at 24 h post treatment. LPS + EPO treatment significantly improved renal function and ameliorated histopathological injury when compared to the LPS treated group. Results showed that EPO treatment attenuates renal tubular apoptosis through: (a) the overexpression of EPO-R in tubular interstitial cells, (b) the reduction of Bax/Bcl-xL ratio, (c) the inhibition Cytochrome c release into the cytosol and (d) the decrease of the active caspase-3 expression. This study suggests that EPO exerts renoprotection on an experimental model of LPS-induced AKI. EPO induced renoprotection involves an anti-apoptotic effect through the expression of EPO-R and the regulation of the mitochondrial apoptotic pathway. |
description |
Fil: Stoyanoff, Tania Romina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
Stoyanoff, Tania Romina, et al, 2014. Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : Involvement of mitochondria-regulated. Toxicology. Ámsterdam: Elsevier Ireland Ltd, vol. 318, p. 13-21. ISSN 0300-483X. http://repositorio.unne.edu.ar/handle/123456789/33813 |
identifier_str_mv |
Stoyanoff, Tania Romina, et al, 2014. Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin : Involvement of mitochondria-regulated. Toxicology. Ámsterdam: Elsevier Ireland Ltd, vol. 318, p. 13-21. ISSN 0300-483X. |
url |
http://repositorio.unne.edu.ar/handle/123456789/33813 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Atribución-NoComercial-SinDerivadas 2.5 Argentina |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Atribución-NoComercial-SinDerivadas 2.5 Argentina |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Ireland Ltd |
publisher.none.fl_str_mv |
Elsevier Ireland Ltd |
dc.source.none.fl_str_mv |
Toxicology, 2014, vol. 318, p. 13-21. reponame:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) instname:Universidad Nacional del Nordeste |
reponame_str |
Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) |
collection |
Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) |
instname_str |
Universidad Nacional del Nordeste |
repository.name.fl_str_mv |
Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) - Universidad Nacional del Nordeste |
repository.mail.fl_str_mv |
ososa@bib.unne.edu.ar;sergio.alegria@unne.edu.ar |
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1844621656912297984 |
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12.559606 |