Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
- Autores
- Srinivasan, Venkataramanujan; Brzezinski, Amnon; Pandi Perumal, Seithikurippu R.; Spence, David Warren; Cardinali, Daniel Pedro; Brown, Gregory M.
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión enviada
- Descripción
- Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India
Fil: Brzezinski, Amnon. The Hebrew University. Haddassah Medical Center. Department of Obstetrics and Gynecology; Israel
Fil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados Unidos
Fil: Spence, David Warren. Canadian Sleep Institute; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Brown, Gregory M. Centre for Addiction and Mental Health; Canadá
Abstract: Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, nextday hangover and dependence. Non-benzodiazepines are effective for initiating sleep but are not as effective as benzodiazepines for improving sleep quality or efficiency. Furthermore, their prolonged use produces adverse effects similar to those observed with benzodiazepines. Inasmuch as insomnia may be associated with decreased nocturnal melatonin, administration of melatonin is a strategy that has been increasingly used for treating insomnia. Melatonin can be effective for improving sleep quality without the adverse effects associated with hypnotic-sedatives. Ramelteon, a synthetic analog of melatonin which has a longer half life and a stronger affinity for MT1 and MT2 melatonergic receptors, has been reportedly effective for initiating and improving sleep in both adult and elderly insomniacs without showing hangover, dependence, or cognitive impairment. Insomnia is also a major complaint among patients suffering from depressive disorders and is often aggravated by conventional antidepressants especially the specific serotonin reuptake inhibitors. The novel antidepressant agomelatine, a dual action agent with affinity for melatonin MT1 and MT2 receptors and 5-HT2c antagonistic properties, constitutes a new approach to the treatment of major depressive disorders. Agomelatine ameliorates the symptoms of depression and improves the quality and efficiency of sleep. Taken together, the evidence indicates that MT1 / MT2 receptor agonists like ramelteon or agomelatine may be valuable pharmacological tools for insomnia and for depression-associated insomnia. - Fuente
- Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35
- Materia
-
MELATONINA
AGONISTAS
INSOMNIO
DEPRESION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/1609
Ver los metadatos del registro completo
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Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?Srinivasan, VenkataramanujanBrzezinski, AmnonPandi Perumal, Seithikurippu R.Spence, David WarrenCardinali, Daniel PedroBrown, Gregory M.MELATONINAAGONISTASINSOMNIODEPRESIONFil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; IndiaFil: Brzezinski, Amnon. The Hebrew University. Haddassah Medical Center. Department of Obstetrics and Gynecology; IsraelFil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados UnidosFil: Spence, David Warren. Canadian Sleep Institute; CanadáFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; ArgentinaFil: Brown, Gregory M. Centre for Addiction and Mental Health; CanadáAbstract: Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, nextday hangover and dependence. Non-benzodiazepines are effective for initiating sleep but are not as effective as benzodiazepines for improving sleep quality or efficiency. Furthermore, their prolonged use produces adverse effects similar to those observed with benzodiazepines. Inasmuch as insomnia may be associated with decreased nocturnal melatonin, administration of melatonin is a strategy that has been increasingly used for treating insomnia. Melatonin can be effective for improving sleep quality without the adverse effects associated with hypnotic-sedatives. Ramelteon, a synthetic analog of melatonin which has a longer half life and a stronger affinity for MT1 and MT2 melatonergic receptors, has been reportedly effective for initiating and improving sleep in both adult and elderly insomniacs without showing hangover, dependence, or cognitive impairment. Insomnia is also a major complaint among patients suffering from depressive disorders and is often aggravated by conventional antidepressants especially the specific serotonin reuptake inhibitors. The novel antidepressant agomelatine, a dual action agent with affinity for melatonin MT1 and MT2 receptors and 5-HT2c antagonistic properties, constitutes a new approach to the treatment of major depressive disorders. Agomelatine ameliorates the symptoms of depression and improves the quality and efficiency of sleep. Taken together, the evidence indicates that MT1 / MT2 receptor agonists like ramelteon or agomelatine may be valuable pharmacological tools for insomnia and for depression-associated insomnia.Elsevier2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16090278-584610.1016/j.pnpbp.2011.03.013Srinivasan, V., et al. Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? [en línea]. Preprint de artículo publicado en Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35. doi:10.1016/j.pnpbp.2011.03.013. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1609Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:19Zoai:ucacris:123456789/1609instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:19.962Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? |
title |
Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? |
spellingShingle |
Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? Srinivasan, Venkataramanujan MELATONINA AGONISTAS INSOMNIO DEPRESION |
title_short |
Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? |
title_full |
Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? |
title_fullStr |
Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? |
title_full_unstemmed |
Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? |
title_sort |
Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? |
dc.creator.none.fl_str_mv |
Srinivasan, Venkataramanujan Brzezinski, Amnon Pandi Perumal, Seithikurippu R. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. |
author |
Srinivasan, Venkataramanujan |
author_facet |
Srinivasan, Venkataramanujan Brzezinski, Amnon Pandi Perumal, Seithikurippu R. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. |
author_role |
author |
author2 |
Brzezinski, Amnon Pandi Perumal, Seithikurippu R. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
MELATONINA AGONISTAS INSOMNIO DEPRESION |
topic |
MELATONINA AGONISTAS INSOMNIO DEPRESION |
dc.description.none.fl_txt_mv |
Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India Fil: Brzezinski, Amnon. The Hebrew University. Haddassah Medical Center. Department of Obstetrics and Gynecology; Israel Fil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados Unidos Fil: Spence, David Warren. Canadian Sleep Institute; Canadá Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina Fil: Brown, Gregory M. Centre for Addiction and Mental Health; Canadá Abstract: Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, nextday hangover and dependence. Non-benzodiazepines are effective for initiating sleep but are not as effective as benzodiazepines for improving sleep quality or efficiency. Furthermore, their prolonged use produces adverse effects similar to those observed with benzodiazepines. Inasmuch as insomnia may be associated with decreased nocturnal melatonin, administration of melatonin is a strategy that has been increasingly used for treating insomnia. Melatonin can be effective for improving sleep quality without the adverse effects associated with hypnotic-sedatives. Ramelteon, a synthetic analog of melatonin which has a longer half life and a stronger affinity for MT1 and MT2 melatonergic receptors, has been reportedly effective for initiating and improving sleep in both adult and elderly insomniacs without showing hangover, dependence, or cognitive impairment. Insomnia is also a major complaint among patients suffering from depressive disorders and is often aggravated by conventional antidepressants especially the specific serotonin reuptake inhibitors. The novel antidepressant agomelatine, a dual action agent with affinity for melatonin MT1 and MT2 receptors and 5-HT2c antagonistic properties, constitutes a new approach to the treatment of major depressive disorders. Agomelatine ameliorates the symptoms of depression and improves the quality and efficiency of sleep. Taken together, the evidence indicates that MT1 / MT2 receptor agonists like ramelteon or agomelatine may be valuable pharmacological tools for insomnia and for depression-associated insomnia. |
description |
Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/submittedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
submittedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/1609 0278-5846 10.1016/j.pnpbp.2011.03.013 Srinivasan, V., et al. Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? [en línea]. Preprint de artículo publicado en Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35. doi:10.1016/j.pnpbp.2011.03.013. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1609 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1609 |
identifier_str_mv |
0278-5846 10.1016/j.pnpbp.2011.03.013 Srinivasan, V., et al. Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? [en línea]. Preprint de artículo publicado en Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35. doi:10.1016/j.pnpbp.2011.03.013. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1609 |
dc.language.none.fl_str_mv |
eng eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638330537639936 |
score |
13.13397 |