Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?

Autores
Srinivasan, Venkataramanujan; Brzezinski, Amnon; Pandi Perumal, Seithikurippu R.; Spence, David Warren; Cardinali, Daniel Pedro; Brown, Gregory M.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India
Fil: Brzezinski, Amnon. The Hebrew University. Haddassah Medical Center. Department of Obstetrics and Gynecology; Israel
Fil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados Unidos
Fil: Spence, David Warren. Canadian Sleep Institute; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Brown, Gregory M. Centre for Addiction and Mental Health; Canadá
Abstract: Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, nextday hangover and dependence. Non-benzodiazepines are effective for initiating sleep but are not as effective as benzodiazepines for improving sleep quality or efficiency. Furthermore, their prolonged use produces adverse effects similar to those observed with benzodiazepines. Inasmuch as insomnia may be associated with decreased nocturnal melatonin, administration of melatonin is a strategy that has been increasingly used for treating insomnia. Melatonin can be effective for improving sleep quality without the adverse effects associated with hypnotic-sedatives. Ramelteon, a synthetic analog of melatonin which has a longer half life and a stronger affinity for MT1 and MT2 melatonergic receptors, has been reportedly effective for initiating and improving sleep in both adult and elderly insomniacs without showing hangover, dependence, or cognitive impairment. Insomnia is also a major complaint among patients suffering from depressive disorders and is often aggravated by conventional antidepressants especially the specific serotonin reuptake inhibitors. The novel antidepressant agomelatine, a dual action agent with affinity for melatonin MT1 and MT2 receptors and 5-HT2c antagonistic properties, constitutes a new approach to the treatment of major depressive disorders. Agomelatine ameliorates the symptoms of depression and improves the quality and efficiency of sleep. Taken together, the evidence indicates that MT1 / MT2 receptor agonists like ramelteon or agomelatine may be valuable pharmacological tools for insomnia and for depression-associated insomnia.
Fuente
Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35
Materia
MELATONINA
AGONISTAS
INSOMNIO
DEPRESION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1609

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oai_identifier_str oai:ucacris:123456789/1609
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?Srinivasan, VenkataramanujanBrzezinski, AmnonPandi Perumal, Seithikurippu R.Spence, David WarrenCardinali, Daniel PedroBrown, Gregory M.MELATONINAAGONISTASINSOMNIODEPRESIONFil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; IndiaFil: Brzezinski, Amnon. The Hebrew University. Haddassah Medical Center. Department of Obstetrics and Gynecology; IsraelFil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados UnidosFil: Spence, David Warren. Canadian Sleep Institute; CanadáFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; ArgentinaFil: Brown, Gregory M. Centre for Addiction and Mental Health; CanadáAbstract: Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, nextday hangover and dependence. Non-benzodiazepines are effective for initiating sleep but are not as effective as benzodiazepines for improving sleep quality or efficiency. Furthermore, their prolonged use produces adverse effects similar to those observed with benzodiazepines. Inasmuch as insomnia may be associated with decreased nocturnal melatonin, administration of melatonin is a strategy that has been increasingly used for treating insomnia. Melatonin can be effective for improving sleep quality without the adverse effects associated with hypnotic-sedatives. Ramelteon, a synthetic analog of melatonin which has a longer half life and a stronger affinity for MT1 and MT2 melatonergic receptors, has been reportedly effective for initiating and improving sleep in both adult and elderly insomniacs without showing hangover, dependence, or cognitive impairment. Insomnia is also a major complaint among patients suffering from depressive disorders and is often aggravated by conventional antidepressants especially the specific serotonin reuptake inhibitors. The novel antidepressant agomelatine, a dual action agent with affinity for melatonin MT1 and MT2 receptors and 5-HT2c antagonistic properties, constitutes a new approach to the treatment of major depressive disorders. Agomelatine ameliorates the symptoms of depression and improves the quality and efficiency of sleep. Taken together, the evidence indicates that MT1 / MT2 receptor agonists like ramelteon or agomelatine may be valuable pharmacological tools for insomnia and for depression-associated insomnia.Elsevier2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16090278-584610.1016/j.pnpbp.2011.03.013Srinivasan, V., et al. Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? [en línea]. Preprint de artículo publicado en Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35. doi:10.1016/j.pnpbp.2011.03.013. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1609Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:19Zoai:ucacris:123456789/1609instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:19.962Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
title Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
spellingShingle Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
Srinivasan, Venkataramanujan
MELATONINA
AGONISTAS
INSOMNIO
DEPRESION
title_short Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
title_full Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
title_fullStr Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
title_full_unstemmed Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
title_sort Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics?
dc.creator.none.fl_str_mv Srinivasan, Venkataramanujan
Brzezinski, Amnon
Pandi Perumal, Seithikurippu R.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
author Srinivasan, Venkataramanujan
author_facet Srinivasan, Venkataramanujan
Brzezinski, Amnon
Pandi Perumal, Seithikurippu R.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
author_role author
author2 Brzezinski, Amnon
Pandi Perumal, Seithikurippu R.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv MELATONINA
AGONISTAS
INSOMNIO
DEPRESION
topic MELATONINA
AGONISTAS
INSOMNIO
DEPRESION
dc.description.none.fl_txt_mv Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India
Fil: Brzezinski, Amnon. The Hebrew University. Haddassah Medical Center. Department of Obstetrics and Gynecology; Israel
Fil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados Unidos
Fil: Spence, David Warren. Canadian Sleep Institute; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Brown, Gregory M. Centre for Addiction and Mental Health; Canadá
Abstract: Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, nextday hangover and dependence. Non-benzodiazepines are effective for initiating sleep but are not as effective as benzodiazepines for improving sleep quality or efficiency. Furthermore, their prolonged use produces adverse effects similar to those observed with benzodiazepines. Inasmuch as insomnia may be associated with decreased nocturnal melatonin, administration of melatonin is a strategy that has been increasingly used for treating insomnia. Melatonin can be effective for improving sleep quality without the adverse effects associated with hypnotic-sedatives. Ramelteon, a synthetic analog of melatonin which has a longer half life and a stronger affinity for MT1 and MT2 melatonergic receptors, has been reportedly effective for initiating and improving sleep in both adult and elderly insomniacs without showing hangover, dependence, or cognitive impairment. Insomnia is also a major complaint among patients suffering from depressive disorders and is often aggravated by conventional antidepressants especially the specific serotonin reuptake inhibitors. The novel antidepressant agomelatine, a dual action agent with affinity for melatonin MT1 and MT2 receptors and 5-HT2c antagonistic properties, constitutes a new approach to the treatment of major depressive disorders. Agomelatine ameliorates the symptoms of depression and improves the quality and efficiency of sleep. Taken together, the evidence indicates that MT1 / MT2 receptor agonists like ramelteon or agomelatine may be valuable pharmacological tools for insomnia and for depression-associated insomnia.
description Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1609
0278-5846
10.1016/j.pnpbp.2011.03.013
Srinivasan, V., et al. Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? [en línea]. Preprint de artículo publicado en Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35. doi:10.1016/j.pnpbp.2011.03.013. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1609
url https://repositorio.uca.edu.ar/handle/123456789/1609
identifier_str_mv 0278-5846
10.1016/j.pnpbp.2011.03.013
Srinivasan, V., et al. Melatonin agonists in primary insomnia and depression-associated insomnia : are they superior to sedative-hypnotics? [en línea]. Preprint de artículo publicado en Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35. doi:10.1016/j.pnpbp.2011.03.013. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1609
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Progress in Neuro-psychopharmacology & Biological Psychiatry. 2011, 35
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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