Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment

Autores
Aguilera Braico, Diego; Roldán Deamicis, Agustina; Brie, Belén; Balogh, Gabriela Andrea
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentina
Fil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Roldán Deamicis, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brie, Belén. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brie, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment.
Fuente
Biology and Medicine. 201, 9(3)
Materia
CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/14053

id RIUCA_a7d1518aef56c88b73eeaa2624fde2de
oai_identifier_str oai:ucacris:123456789/14053
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatmentAguilera Braico, DiegoRoldán Deamicis, AgustinaBrie, BelénBalogh, Gabriela AndreaCANCER DE MAMAMaitake Pro4XQUIMIOTERAPIAFil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; ArgentinaFil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Roldán Deamicis, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Brie, Belén. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Brie, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment.Omics International2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/140530974-836910.4172/0974-8369.1000394Aguilera Braico, D., et al. Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment [en línea]. Biology and Medicine. 201, 9(3) doi:10.4172/0974-8369.1000394 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14053Biology and Medicine. 201, 9(3)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:35Zoai:ucacris:123456789/14053instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:35.417Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
spellingShingle Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
Aguilera Braico, Diego
CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA
title_short Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_full Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_fullStr Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_full_unstemmed Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_sort Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
dc.creator.none.fl_str_mv Aguilera Braico, Diego
Roldán Deamicis, Agustina
Brie, Belén
Balogh, Gabriela Andrea
author Aguilera Braico, Diego
author_facet Aguilera Braico, Diego
Roldán Deamicis, Agustina
Brie, Belén
Balogh, Gabriela Andrea
author_role author
author2 Roldán Deamicis, Agustina
Brie, Belén
Balogh, Gabriela Andrea
author2_role author
author
author
dc.subject.none.fl_str_mv CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA
topic CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA
dc.description.none.fl_txt_mv Fil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentina
Fil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Roldán Deamicis, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brie, Belén. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brie, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment.
description Fil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentina
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/14053
0974-8369
10.4172/0974-8369.1000394
Aguilera Braico, D., et al. Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment [en línea]. Biology and Medicine. 201, 9(3) doi:10.4172/0974-8369.1000394 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14053
url https://repositorio.uca.edu.ar/handle/123456789/14053
identifier_str_mv 0974-8369
10.4172/0974-8369.1000394
Aguilera Braico, D., et al. Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment [en línea]. Biology and Medicine. 201, 9(3) doi:10.4172/0974-8369.1000394 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14053
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Omics International
publisher.none.fl_str_mv Omics International
dc.source.none.fl_str_mv Biology and Medicine. 201, 9(3)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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