Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
- Autores
- Aguilera Braico, Diego; Roldán Deamicis, Agustina; Brie, Belén; Balogh, Gabriela Andrea
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentina
Fil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Roldán Deamicis, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brie, Belén. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brie, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment. - Fuente
- Biology and Medicine. 201, 9(3)
- Materia
-
CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/14053
Ver los metadatos del registro completo
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oai:ucacris:123456789/14053 |
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Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatmentAguilera Braico, DiegoRoldán Deamicis, AgustinaBrie, BelénBalogh, Gabriela AndreaCANCER DE MAMAMaitake Pro4XQUIMIOTERAPIAFil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; ArgentinaFil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Roldán Deamicis, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Brie, Belén. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Brie, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment.Omics International2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/140530974-836910.4172/0974-8369.1000394Aguilera Braico, D., et al. Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment [en línea]. Biology and Medicine. 201, 9(3) doi:10.4172/0974-8369.1000394 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14053Biology and Medicine. 201, 9(3)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:35Zoai:ucacris:123456789/14053instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:35.417Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment |
title |
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment |
spellingShingle |
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment Aguilera Braico, Diego CANCER DE MAMA Maitake Pro4X QUIMIOTERAPIA |
title_short |
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment |
title_full |
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment |
title_fullStr |
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment |
title_full_unstemmed |
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment |
title_sort |
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment |
dc.creator.none.fl_str_mv |
Aguilera Braico, Diego Roldán Deamicis, Agustina Brie, Belén Balogh, Gabriela Andrea |
author |
Aguilera Braico, Diego |
author_facet |
Aguilera Braico, Diego Roldán Deamicis, Agustina Brie, Belén Balogh, Gabriela Andrea |
author_role |
author |
author2 |
Roldán Deamicis, Agustina Brie, Belén Balogh, Gabriela Andrea |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
CANCER DE MAMA Maitake Pro4X QUIMIOTERAPIA |
topic |
CANCER DE MAMA Maitake Pro4X QUIMIOTERAPIA |
dc.description.none.fl_txt_mv |
Fil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentina Fil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Roldán Deamicis, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Brie, Belén. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Brie, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Abstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment. |
description |
Fil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentina |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/14053 0974-8369 10.4172/0974-8369.1000394 Aguilera Braico, D., et al. Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment [en línea]. Biology and Medicine. 201, 9(3) doi:10.4172/0974-8369.1000394 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14053 |
url |
https://repositorio.uca.edu.ar/handle/123456789/14053 |
identifier_str_mv |
0974-8369 10.4172/0974-8369.1000394 Aguilera Braico, D., et al. Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment [en línea]. Biology and Medicine. 201, 9(3) doi:10.4172/0974-8369.1000394 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14053 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Omics International |
publisher.none.fl_str_mv |
Omics International |
dc.source.none.fl_str_mv |
Biology and Medicine. 201, 9(3) reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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13.13397 |