Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
- Autores
- Barrantes, Francisco José
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effects transduced via recognition sites on the target membrane protein. The nicotinic acetylcholine receptor (nAChR), the paradigm member of the pentameric ligand-gated ion channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by both mechanisms. Reciprocally, the nAChR protein exerts influence on its surrounding interstitial lipids. Folding, conformational equilibria, ligand binding, ion permeation, topography, and diffusion of the nAChR are modulated by membrane lipids. The knowledge gained from biophysical studies of this prototypic membrane protein can be applied to other neurotransmitter receptors and most other integral membrane proteins. - Fuente
- Frontiers in cell and developmental biology. 2024 (11),1328875.
- Materia
-
MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/18421
Ver los metadatos del registro completo
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oai:ucacris:123456789/18421 |
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network_name_str |
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Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipidsBarrantes, Francisco JoséMEMBRANA PLASMATICAPLASMALEMALIPIDOS DE MEMBRANAINFLUENCIA DE LOS LIPIDOS EN LA MEMBRANAPROTEINASCOLESTEROLRECEPTOR NICOTINICO DE ACETILCOLINAFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effects transduced via recognition sites on the target membrane protein. The nicotinic acetylcholine receptor (nAChR), the paradigm member of the pentameric ligand-gated ion channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by both mechanisms. Reciprocally, the nAChR protein exerts influence on its surrounding interstitial lipids. Folding, conformational equilibria, ligand binding, ion permeation, topography, and diffusion of the nAChR are modulated by membrane lipids. The knowledge gained from biophysical studies of this prototypic membrane protein can be applied to other neurotransmitter receptors and most other integral membrane proteins.Frontiers Media2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/184212296-634X (online)10.3389/fcell.2023.1328875Barrantes, F.J. Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids [en línea]. Frontiers in cell and developmental biology. 2024 (11),1328875. doi: 10.3389/fcell.2023.1328875. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18421Frontiers in cell and developmental biology. 2024 (11),1328875.reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:59:51Zoai:ucacris:123456789/18421instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:52.092Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids |
title |
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids |
spellingShingle |
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids Barrantes, Francisco José MEMBRANA PLASMATICA PLASMALEMA LIPIDOS DE MEMBRANA INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA PROTEINAS COLESTEROL RECEPTOR NICOTINICO DE ACETILCOLINA |
title_short |
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids |
title_full |
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids |
title_fullStr |
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids |
title_full_unstemmed |
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids |
title_sort |
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids |
dc.creator.none.fl_str_mv |
Barrantes, Francisco José |
author |
Barrantes, Francisco José |
author_facet |
Barrantes, Francisco José |
author_role |
author |
dc.subject.none.fl_str_mv |
MEMBRANA PLASMATICA PLASMALEMA LIPIDOS DE MEMBRANA INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA PROTEINAS COLESTEROL RECEPTOR NICOTINICO DE ACETILCOLINA |
topic |
MEMBRANA PLASMATICA PLASMALEMA LIPIDOS DE MEMBRANA INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA PROTEINAS COLESTEROL RECEPTOR NICOTINICO DE ACETILCOLINA |
dc.description.none.fl_txt_mv |
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effects transduced via recognition sites on the target membrane protein. The nicotinic acetylcholine receptor (nAChR), the paradigm member of the pentameric ligand-gated ion channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by both mechanisms. Reciprocally, the nAChR protein exerts influence on its surrounding interstitial lipids. Folding, conformational equilibria, ligand binding, ion permeation, topography, and diffusion of the nAChR are modulated by membrane lipids. The knowledge gained from biophysical studies of this prototypic membrane protein can be applied to other neurotransmitter receptors and most other integral membrane proteins. |
description |
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/18421 2296-634X (online) 10.3389/fcell.2023.1328875 Barrantes, F.J. Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids [en línea]. Frontiers in cell and developmental biology. 2024 (11),1328875. doi: 10.3389/fcell.2023.1328875. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18421 |
url |
https://repositorio.uca.edu.ar/handle/123456789/18421 |
identifier_str_mv |
2296-634X (online) 10.3389/fcell.2023.1328875 Barrantes, F.J. Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids [en línea]. Frontiers in cell and developmental biology. 2024 (11),1328875. doi: 10.3389/fcell.2023.1328875. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18421 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
Frontiers in cell and developmental biology. 2024 (11),1328875. reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
_version_ |
1836638373963366400 |
score |
13.13397 |