Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids

Autores
Barrantes, Francisco José
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effects transduced via recognition sites on the target membrane protein. The nicotinic acetylcholine receptor (nAChR), the paradigm member of the pentameric ligand-gated ion channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by both mechanisms. Reciprocally, the nAChR protein exerts influence on its surrounding interstitial lipids. Folding, conformational equilibria, ligand binding, ion permeation, topography, and diffusion of the nAChR are modulated by membrane lipids. The knowledge gained from biophysical studies of this prototypic membrane protein can be applied to other neurotransmitter receptors and most other integral membrane proteins.
Fuente
Frontiers in cell and developmental biology. 2024 (11),1328875.
Materia
MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/18421

id RIUCA_6d84382912a3dece9d674c4185a6a67f
oai_identifier_str oai:ucacris:123456789/18421
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipidsBarrantes, Francisco JoséMEMBRANA PLASMATICAPLASMALEMALIPIDOS DE MEMBRANAINFLUENCIA DE LOS LIPIDOS EN LA MEMBRANAPROTEINASCOLESTEROLRECEPTOR NICOTINICO DE ACETILCOLINAFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effects transduced via recognition sites on the target membrane protein. The nicotinic acetylcholine receptor (nAChR), the paradigm member of the pentameric ligand-gated ion channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by both mechanisms. Reciprocally, the nAChR protein exerts influence on its surrounding interstitial lipids. Folding, conformational equilibria, ligand binding, ion permeation, topography, and diffusion of the nAChR are modulated by membrane lipids. The knowledge gained from biophysical studies of this prototypic membrane protein can be applied to other neurotransmitter receptors and most other integral membrane proteins.Frontiers Media2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/184212296-634X (online)10.3389/fcell.2023.1328875Barrantes, F.J. Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids [en línea]. Frontiers in cell and developmental biology. 2024 (11),1328875. doi: 10.3389/fcell.2023.1328875. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18421Frontiers in cell and developmental biology. 2024 (11),1328875.reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:59:51Zoai:ucacris:123456789/18421instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:52.092Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
spellingShingle Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
Barrantes, Francisco José
MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA
title_short Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_full Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_fullStr Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_full_unstemmed Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_sort Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
dc.creator.none.fl_str_mv Barrantes, Francisco José
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_role author
dc.subject.none.fl_str_mv MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA
topic MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA
dc.description.none.fl_txt_mv Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effects transduced via recognition sites on the target membrane protein. The nicotinic acetylcholine receptor (nAChR), the paradigm member of the pentameric ligand-gated ion channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by both mechanisms. Reciprocally, the nAChR protein exerts influence on its surrounding interstitial lipids. Folding, conformational equilibria, ligand binding, ion permeation, topography, and diffusion of the nAChR are modulated by membrane lipids. The knowledge gained from biophysical studies of this prototypic membrane protein can be applied to other neurotransmitter receptors and most other integral membrane proteins.
description Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/18421
2296-634X (online)
10.3389/fcell.2023.1328875
Barrantes, F.J. Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids [en línea]. Frontiers in cell and developmental biology. 2024 (11),1328875. doi: 10.3389/fcell.2023.1328875. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18421
url https://repositorio.uca.edu.ar/handle/123456789/18421
identifier_str_mv 2296-634X (online)
10.3389/fcell.2023.1328875
Barrantes, F.J. Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids [en línea]. Frontiers in cell and developmental biology. 2024 (11),1328875. doi: 10.3389/fcell.2023.1328875. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18421
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Frontiers in cell and developmental biology. 2024 (11),1328875.
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397