Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases

Autores
Vallés, Ana Sofía; Barrantes, Francisco José
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Vallés, Ana Sofía. Universidad Nacional del Sur. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Abstract: The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review focuses on the nicotinic acetylcholine receptor (nAChR) and its role in addiction and in neurodegenerative and neuropsychiatric diseases and epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly through the involvement of α7 nAChRs expressed in brain and in peripheral immune cells. Evidence suggests that these neuroinflammatory processes trigger and aggravate pathological states. We discuss the preclinical evidence demonstrating the therapeutic potential of nAChR ligands in Alzheimer disease, Parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. PubMed and Google Scholar bibliographic databases were searched with the keywords indicated below.
Fuente
Cells.Vol.12, No.16, 2023
Materia
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE PARKINSON
EPILEPSIA
ESPECTRO DE ESQUIZOFRENIA
ADICCIONES
SALUD
ENFERMEDADES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/16987
Acceder
id RIUCA_6557d3366142572bf5ed58691325985f
oai_identifier_str oai:ucacris:123456789/16987
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseasesVallés, Ana SofíaBarrantes, Francisco JoséENFERMEDAD DE ALZHEIMERENFERMEDAD DE PARKINSONEPILEPSIAESPECTRO DE ESQUIZOFRENIAADICCIONESSALUDENFERMEDADESFil: Vallés, Ana Sofía. Universidad Nacional del Sur. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina; ArgentinaFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; ArgentinaAbstract: The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review focuses on the nicotinic acetylcholine receptor (nAChR) and its role in addiction and in neurodegenerative and neuropsychiatric diseases and epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly through the involvement of α7 nAChRs expressed in brain and in peripheral immune cells. Evidence suggests that these neuroinflammatory processes trigger and aggravate pathological states. We discuss the preclinical evidence demonstrating the therapeutic potential of nAChR ligands in Alzheimer disease, Parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. PubMed and Google Scholar bibliographic databases were searched with the keywords indicated below.Multidisciplinary Digital Publishing Institute2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/169872073-4409 (online)10.3390/cells12162051Vallés, A. S., Barrantes, F. J. Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases [en línea]. Cells. 2023, 12(16). doi:10.3390/cells12162051. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16987Cells.Vol.12, No.16, 2023reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-11-13T10:18:04Zoai:ucacris:123456789/16987instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-11-13 10:18:04.364Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
spellingShingle Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
Vallés, Ana Sofía
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE PARKINSON
EPILEPSIA
ESPECTRO DE ESQUIZOFRENIA
ADICCIONES
SALUD
ENFERMEDADES
title_short Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_full Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_fullStr Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_full_unstemmed Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_sort Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
dc.creator.none.fl_str_mv Vallés, Ana Sofía
Barrantes, Francisco José
author Vallés, Ana Sofía
author_facet Vallés, Ana Sofía
Barrantes, Francisco José
author_role author
author2 Barrantes, Francisco José
author2_role author
dc.subject.none.fl_str_mv ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE PARKINSON
EPILEPSIA
ESPECTRO DE ESQUIZOFRENIA
ADICCIONES
SALUD
ENFERMEDADES
topic ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE PARKINSON
EPILEPSIA
ESPECTRO DE ESQUIZOFRENIA
ADICCIONES
SALUD
ENFERMEDADES
dc.description.none.fl_txt_mv Fil: Vallés, Ana Sofía. Universidad Nacional del Sur. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Abstract: The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review focuses on the nicotinic acetylcholine receptor (nAChR) and its role in addiction and in neurodegenerative and neuropsychiatric diseases and epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly through the involvement of α7 nAChRs expressed in brain and in peripheral immune cells. Evidence suggests that these neuroinflammatory processes trigger and aggravate pathological states. We discuss the preclinical evidence demonstrating the therapeutic potential of nAChR ligands in Alzheimer disease, Parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. PubMed and Google Scholar bibliographic databases were searched with the keywords indicated below.
description Fil: Vallés, Ana Sofía. Universidad Nacional del Sur. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/16987
2073-4409 (online)
10.3390/cells12162051
Vallés, A. S., Barrantes, F. J. Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases [en línea]. Cells. 2023, 12(16). doi:10.3390/cells12162051. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16987
url https://repositorio.uca.edu.ar/handle/123456789/16987
identifier_str_mv 2073-4409 (online)
10.3390/cells12162051
Vallés, A. S., Barrantes, F. J. Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases [en línea]. Cells. 2023, 12(16). doi:10.3390/cells12162051. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16987
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv Cells.Vol.12, No.16, 2023
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
_version_ 1848683867650654208
score 12.742515

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