Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude

Autores
Vigo, Daniel Eduardo; Pérez Lloret, Santiago; Videla, Alejandro J.; Pérez Chada, Daniel; Hünicken, Horacio M.; Mercuri, Jorge; Romero, Ramón; Nicola Siri, Leonardo C.; Cardinali, Daniel Pedro
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Videla, Alejandro J. Hospital Universitario Austral. Servicio de Neumonología; Argentina
Fil: Pérez Chada, Daniel. Hospital Universitario Austral. Servicio de Neumonología; Argentina
Fil: Hünicken, Horacio M. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina
Fil: Mercuri, Jorge. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina
Fil: Romero, Ramón. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina
Fil: Nicola Siri, Leonardo C. Universidad Nacional de Entre Ríos. Facultad de Bioingeniería. Departamento de Biología; Argentina
Fil: Nicola Siri, Leonardo C. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Acute hypobaric hypoxia is associated with autonomic changes that bring a global reduction of linear heart rate variability (HRV). Although changes in nonlinear HRV can be associated with physiological stress and are relevant predictors of fatal arrhythmias in ischemic heart disease, to what extent these components vary in sudden hypobaric hypoxia is not known. Methods: Twelve military pilots were supplemented with increasing concentrations of oxygen during decompression to 8,230 m in a hypobaric chamber. Linear and nonlinear HRV was evaluated at 8,230 m altitude before, during and after oxygen flow deprivation. Linear HRV was assessed through traditional time- and frequency- domain analysis. Nonlinear HRV was quantified through the short term fractal correlation exponent alpha (αs) and the Sample Entropy index (SampEn). Results: Hypoxia was related to a decrease in linear heart rate variability indexes at all frequency levels. A non significant decrease in αs (basal: 1.39 ± 0.07, hypoxia: 1.11 ± 0.13, recovery: 1.41 ± 0.05, p = 0.054) and a significant increase in SampEn (basal: 1.07 ± 0.11, hypoxia: 1.45 ± 0.12, recovery: 1.43 ± 0.09, p = 0.018) were detected. Conclusions: The observed pattern of diminished linear heart rate variability and increased nonlinear heart rate variability is similar to that seen in subjects undergoing heavy exercise or in patients with ischemic heart disease and high risk for ventricular fibrillation.
Fuente
Wilderness & Environmental Medicine. 2010, 21 (1)
Materia
SISTEMA NERVIOSO AUTONOMO
FRECUENCIA CARDIACA
HIPOXIA
ALTITUD
ESTUDIO DE CASOS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1637
Acceder
id RIUCA_29552e195cf529655ef0efd15706a9df
oai_identifier_str oai:ucacris:123456789/1637
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitudeVigo, Daniel EduardoPérez Lloret, SantiagoVidela, Alejandro J.Pérez Chada, DanielHünicken, Horacio M.Mercuri, JorgeRomero, RamónNicola Siri, Leonardo C.Cardinali, Daniel PedroSISTEMA NERVIOSO AUTONOMOFRECUENCIA CARDIACAHIPOXIAALTITUDESTUDIO DE CASOSFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Videla, Alejandro J. Hospital Universitario Austral. Servicio de Neumonología; ArgentinaFil: Pérez Chada, Daniel. Hospital Universitario Austral. Servicio de Neumonología; ArgentinaFil: Hünicken, Horacio M. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; ArgentinaFil: Mercuri, Jorge. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; ArgentinaFil: Romero, Ramón. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; ArgentinaFil: Nicola Siri, Leonardo C. Universidad Nacional de Entre Ríos. Facultad de Bioingeniería. Departamento de Biología; ArgentinaFil: Nicola Siri, Leonardo C. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Acute hypobaric hypoxia is associated with autonomic changes that bring a global reduction of linear heart rate variability (HRV). Although changes in nonlinear HRV can be associated with physiological stress and are relevant predictors of fatal arrhythmias in ischemic heart disease, to what extent these components vary in sudden hypobaric hypoxia is not known. Methods: Twelve military pilots were supplemented with increasing concentrations of oxygen during decompression to 8,230 m in a hypobaric chamber. Linear and nonlinear HRV was evaluated at 8,230 m altitude before, during and after oxygen flow deprivation. Linear HRV was assessed through traditional time- and frequency- domain analysis. Nonlinear HRV was quantified through the short term fractal correlation exponent alpha (αs) and the Sample Entropy index (SampEn). Results: Hypoxia was related to a decrease in linear heart rate variability indexes at all frequency levels. A non significant decrease in αs (basal: 1.39 ± 0.07, hypoxia: 1.11 ± 0.13, recovery: 1.41 ± 0.05, p = 0.054) and a significant increase in SampEn (basal: 1.07 ± 0.11, hypoxia: 1.45 ± 0.12, recovery: 1.43 ± 0.09, p = 0.018) were detected. Conclusions: The observed pattern of diminished linear heart rate variability and increased nonlinear heart rate variability is similar to that seen in subjects undergoing heavy exercise or in patients with ischemic heart disease and high risk for ventricular fibrillation.Elsevier2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/163710.1016/j.wem.2009.12.02220591347Vigo, D. E., et al. Heart rate nonlinear dynamics during sudden hypoxia at 8230 m simulated altitude [en línea]. Wilderness & Environmental Medicine. 2010, 21 (1). doi:10.1016/j.wem.2009.12.022. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1637Wilderness & Environmental Medicine. 2010, 21 (1)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:21Zoai:ucacris:123456789/1637instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:21.812Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude
title Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude
spellingShingle Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude
Vigo, Daniel Eduardo
SISTEMA NERVIOSO AUTONOMO
FRECUENCIA CARDIACA
HIPOXIA
ALTITUD
ESTUDIO DE CASOS
title_short Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude
title_full Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude
title_fullStr Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude
title_full_unstemmed Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude
title_sort Heart rate nonlinear dynamics during sudden hypoxia at 8,230 m simulated altitude
dc.creator.none.fl_str_mv Vigo, Daniel Eduardo
Pérez Lloret, Santiago
Videla, Alejandro J.
Pérez Chada, Daniel
Hünicken, Horacio M.
Mercuri, Jorge
Romero, Ramón
Nicola Siri, Leonardo C.
Cardinali, Daniel Pedro
author Vigo, Daniel Eduardo
author_facet Vigo, Daniel Eduardo
Pérez Lloret, Santiago
Videla, Alejandro J.
Pérez Chada, Daniel
Hünicken, Horacio M.
Mercuri, Jorge
Romero, Ramón
Nicola Siri, Leonardo C.
Cardinali, Daniel Pedro
author_role author
author2 Pérez Lloret, Santiago
Videla, Alejandro J.
Pérez Chada, Daniel
Hünicken, Horacio M.
Mercuri, Jorge
Romero, Ramón
Nicola Siri, Leonardo C.
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SISTEMA NERVIOSO AUTONOMO
FRECUENCIA CARDIACA
HIPOXIA
ALTITUD
ESTUDIO DE CASOS
topic SISTEMA NERVIOSO AUTONOMO
FRECUENCIA CARDIACA
HIPOXIA
ALTITUD
ESTUDIO DE CASOS
dc.description.none.fl_txt_mv Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Videla, Alejandro J. Hospital Universitario Austral. Servicio de Neumonología; Argentina
Fil: Pérez Chada, Daniel. Hospital Universitario Austral. Servicio de Neumonología; Argentina
Fil: Hünicken, Horacio M. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina
Fil: Mercuri, Jorge. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina
Fil: Romero, Ramón. Fuerza Aérea Argentina. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina
Fil: Nicola Siri, Leonardo C. Universidad Nacional de Entre Ríos. Facultad de Bioingeniería. Departamento de Biología; Argentina
Fil: Nicola Siri, Leonardo C. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Acute hypobaric hypoxia is associated with autonomic changes that bring a global reduction of linear heart rate variability (HRV). Although changes in nonlinear HRV can be associated with physiological stress and are relevant predictors of fatal arrhythmias in ischemic heart disease, to what extent these components vary in sudden hypobaric hypoxia is not known. Methods: Twelve military pilots were supplemented with increasing concentrations of oxygen during decompression to 8,230 m in a hypobaric chamber. Linear and nonlinear HRV was evaluated at 8,230 m altitude before, during and after oxygen flow deprivation. Linear HRV was assessed through traditional time- and frequency- domain analysis. Nonlinear HRV was quantified through the short term fractal correlation exponent alpha (αs) and the Sample Entropy index (SampEn). Results: Hypoxia was related to a decrease in linear heart rate variability indexes at all frequency levels. A non significant decrease in αs (basal: 1.39 ± 0.07, hypoxia: 1.11 ± 0.13, recovery: 1.41 ± 0.05, p = 0.054) and a significant increase in SampEn (basal: 1.07 ± 0.11, hypoxia: 1.45 ± 0.12, recovery: 1.43 ± 0.09, p = 0.018) were detected. Conclusions: The observed pattern of diminished linear heart rate variability and increased nonlinear heart rate variability is similar to that seen in subjects undergoing heavy exercise or in patients with ischemic heart disease and high risk for ventricular fibrillation.
description Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1637
10.1016/j.wem.2009.12.022
20591347
Vigo, D. E., et al. Heart rate nonlinear dynamics during sudden hypoxia at 8230 m simulated altitude [en línea]. Wilderness & Environmental Medicine. 2010, 21 (1). doi:10.1016/j.wem.2009.12.022. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1637
url https://repositorio.uca.edu.ar/handle/123456789/1637
identifier_str_mv 10.1016/j.wem.2009.12.022
20591347
Vigo, D. E., et al. Heart rate nonlinear dynamics during sudden hypoxia at 8230 m simulated altitude [en línea]. Wilderness & Environmental Medicine. 2010, 21 (1). doi:10.1016/j.wem.2009.12.022. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1637
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Wilderness & Environmental Medicine. 2010, 21 (1)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
_version_ 1836638330582728704
score 13.13397

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