Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder

Autores
Wainsztein, Agustina E.; Abulafia, Carolina Andrea; Goldberg, Ximena; Camacho-Téllez, Vicente; Vulcano, Mercedes; Vigo, Daniel Eduardo; Menchón, José M.; Soriano-Mas, Carles; Nemeroff, Charles B.; Guinjoan, Salvador M.; Castro, Mariana N.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Wainsztein, Agustina E. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Wainsztein, Agustina E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wainsztein, Agustina E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Abulafia, Carolina Andrea. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Abulafia, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Goldberg, Ximena. Universitat Autónoma de Barcelona; España
Fil: Camacho-Téllez, Vicente. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Camacho-Téllez, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vulcano, Mercedes. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Vulcano, Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; Argentina
Fil: Fil: Wainsztein, Agustina E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; Argentina
Fil: Abulafia, Carolina Andrea. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Menchón, José M. Bellvitge University Hospital. Department of Psychiatry; España
Fil: Menchón, José M. Carlos III Health Institute; España
Fil: Menchón, José M. University of Barcelona. Bellvitge Campus. Department of Clinical Sciences; España
Fil: Soriano-Mas, Carles. Bellvitge University Hospital. Department of Psychiatry; España
Fil: Soriano-Mas, Carles. Carlos III Health Institute; España
Fil: Soriano-Mas, Carles. Universitat Autónoma de Barcelona; España
Fil: Nemeroff, Charles B. The University of Texas at Austin. Dell Medical School; Estados Unidos
Fil: Guinjoan, Salvador M. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; Argentina
Fil: Guinjoan, Salvador M. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Guinjoan, Salvador M. University of Barcelona. Bellvitge Campus. Department of Clinical Sciences; España
Fil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Mariana N. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Abstract: Background: Heart rate variability (HRV), a measure of autonomic nervous system activity, has been studied in a number of psychiatric disorders during the resting state but evidence on its circadian patterns in Major Depressive Disorder (MDD) and Borderline Personality Disorder (BPD) is scarce. We sought to identify and differentiate HRV circadian patterns in MDD, BPD and healthy controls (HC) while exploring potential physiological mechanisms associated with mood and emotion dysregulation. Methods: 24-Hour electrocardiographic recordings were obtained from fifty subjects (16 HC, 18 BPD, 16 MDD). HRV was calculated during sleep and wake periods. Associations with mood and affect measures, and with cognitive emotion regulation strategies and self-reported difficulties in emotion regulation (DERS) were examined. Participant’s resilience traits were explored in relation to mood and emotion regulation variables. Results: Lower diurnal measures of HRV (i.e, RMSSD and HF) were observed in MDD subjects compared to HCs. Decreased HF was observed during wake vs. sleep in MDD patients. HAM-D and negative affect scores negatively correlated with HRV in MDD and BPD respectively. MDD and BPD exhibited a positive relationship between the implementation of emotion regulation strategies and HRV compared to HC. Increased resilience was associated with lower HAM-D and DERS scores in BPD and HC. Conclusion: HRV alterations characterized by low diurnal cardiac parasympathetic control constitute a potential trait biomarker of major depression and psychiatric vulnerability to depressive episodes in BPD. HRV anomalies in MDD may persist during clinical remission. Diurnal HRV may represent a psychophysiological index of mood and emotion regulation.
Fuente
Personalized Medicine in Psychiatry. 2020, 23-24
Materia
EMOCIONES
RITMO CIRCADIANO
RITMO CARDIACO
DEPRESION
PERSONALIDAD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/14232
Acceder
id RIUCA_07ac7a0f62ca08745745fc31059da100
oai_identifier_str oai:ucacris:123456789/14232
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorderWainsztein, Agustina E.Abulafia, Carolina AndreaGoldberg, XimenaCamacho-Téllez, VicenteVulcano, MercedesVigo, Daniel EduardoMenchón, José M.Soriano-Mas, CarlesNemeroff, Charles B.Guinjoan, Salvador M.Castro, Mariana N.EMOCIONESRITMO CIRCADIANORITMO CARDIACODEPRESIONPERSONALIDADFil: Wainsztein, Agustina E. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Wainsztein, Agustina E. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Wainsztein, Agustina E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Abulafia, Carolina Andrea. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Abulafia, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Goldberg, Ximena. Universitat Autónoma de Barcelona; EspañaFil: Camacho-Téllez, Vicente. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Camacho-Téllez, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vulcano, Mercedes. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Vulcano, Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; ArgentinaFil: Fil: Wainsztein, Agustina E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; ArgentinaFil: Abulafia, Carolina Andrea. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; ArgentinaFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Menchón, José M. Bellvitge University Hospital. Department of Psychiatry; EspañaFil: Menchón, José M. Carlos III Health Institute; EspañaFil: Menchón, José M. University of Barcelona. Bellvitge Campus. Department of Clinical Sciences; EspañaFil: Soriano-Mas, Carles. Bellvitge University Hospital. Department of Psychiatry; EspañaFil: Soriano-Mas, Carles. Carlos III Health Institute; EspañaFil: Soriano-Mas, Carles. Universitat Autónoma de Barcelona; EspañaFil: Nemeroff, Charles B. The University of Texas at Austin. Dell Medical School; Estados UnidosFil: Guinjoan, Salvador M. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; ArgentinaFil: Guinjoan, Salvador M. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Guinjoan, Salvador M. University of Barcelona. Bellvitge Campus. Department of Clinical Sciences; EspañaFil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castro, Mariana N. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; ArgentinaAbstract: Background: Heart rate variability (HRV), a measure of autonomic nervous system activity, has been studied in a number of psychiatric disorders during the resting state but evidence on its circadian patterns in Major Depressive Disorder (MDD) and Borderline Personality Disorder (BPD) is scarce. We sought to identify and differentiate HRV circadian patterns in MDD, BPD and healthy controls (HC) while exploring potential physiological mechanisms associated with mood and emotion dysregulation. Methods: 24-Hour electrocardiographic recordings were obtained from fifty subjects (16 HC, 18 BPD, 16 MDD). HRV was calculated during sleep and wake periods. Associations with mood and affect measures, and with cognitive emotion regulation strategies and self-reported difficulties in emotion regulation (DERS) were examined. Participant’s resilience traits were explored in relation to mood and emotion regulation variables. Results: Lower diurnal measures of HRV (i.e, RMSSD and HF) were observed in MDD subjects compared to HCs. Decreased HF was observed during wake vs. sleep in MDD patients. HAM-D and negative affect scores negatively correlated with HRV in MDD and BPD respectively. MDD and BPD exhibited a positive relationship between the implementation of emotion regulation strategies and HRV compared to HC. Increased resilience was associated with lower HAM-D and DERS scores in BPD and HC. Conclusion: HRV alterations characterized by low diurnal cardiac parasympathetic control constitute a potential trait biomarker of major depression and psychiatric vulnerability to depressive episodes in BPD. HRV anomalies in MDD may persist during clinical remission. Diurnal HRV may represent a psychophysiological index of mood and emotion regulation.Elsevier2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/142322468-171710.1016/j.pmip.2020.100065Wainsztein, A.E., et al. Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder [en línea]. Personalized Medicine in Psychiatry. 2020, 23-24 doi:10.1016/j.pmip.2020.100065 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14232Personalized Medicine in Psychiatry. 2020, 23-24reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:38Zoai:ucacris:123456789/14232instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:38.355Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder
title Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder
spellingShingle Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder
Wainsztein, Agustina E.
EMOCIONES
RITMO CIRCADIANO
RITMO CARDIACO
DEPRESION
PERSONALIDAD
title_short Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder
title_full Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder
title_fullStr Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder
title_full_unstemmed Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder
title_sort Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder
dc.creator.none.fl_str_mv Wainsztein, Agustina E.
Abulafia, Carolina Andrea
Goldberg, Ximena
Camacho-Téllez, Vicente
Vulcano, Mercedes
Vigo, Daniel Eduardo
Menchón, José M.
Soriano-Mas, Carles
Nemeroff, Charles B.
Guinjoan, Salvador M.
Castro, Mariana N.
author Wainsztein, Agustina E.
author_facet Wainsztein, Agustina E.
Abulafia, Carolina Andrea
Goldberg, Ximena
Camacho-Téllez, Vicente
Vulcano, Mercedes
Vigo, Daniel Eduardo
Menchón, José M.
Soriano-Mas, Carles
Nemeroff, Charles B.
Guinjoan, Salvador M.
Castro, Mariana N.
author_role author
author2 Abulafia, Carolina Andrea
Goldberg, Ximena
Camacho-Téllez, Vicente
Vulcano, Mercedes
Vigo, Daniel Eduardo
Menchón, José M.
Soriano-Mas, Carles
Nemeroff, Charles B.
Guinjoan, Salvador M.
Castro, Mariana N.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EMOCIONES
RITMO CIRCADIANO
RITMO CARDIACO
DEPRESION
PERSONALIDAD
topic EMOCIONES
RITMO CIRCADIANO
RITMO CARDIACO
DEPRESION
PERSONALIDAD
dc.description.none.fl_txt_mv Fil: Wainsztein, Agustina E. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Wainsztein, Agustina E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wainsztein, Agustina E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Abulafia, Carolina Andrea. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Abulafia, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Goldberg, Ximena. Universitat Autónoma de Barcelona; España
Fil: Camacho-Téllez, Vicente. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Camacho-Téllez, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vulcano, Mercedes. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Vulcano, Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; Argentina
Fil: Fil: Wainsztein, Agustina E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; Argentina
Fil: Abulafia, Carolina Andrea. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Menchón, José M. Bellvitge University Hospital. Department of Psychiatry; España
Fil: Menchón, José M. Carlos III Health Institute; España
Fil: Menchón, José M. University of Barcelona. Bellvitge Campus. Department of Clinical Sciences; España
Fil: Soriano-Mas, Carles. Bellvitge University Hospital. Department of Psychiatry; España
Fil: Soriano-Mas, Carles. Carlos III Health Institute; España
Fil: Soriano-Mas, Carles. Universitat Autónoma de Barcelona; España
Fil: Nemeroff, Charles B. The University of Texas at Austin. Dell Medical School; Estados Unidos
Fil: Guinjoan, Salvador M. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría; Argentina
Fil: Guinjoan, Salvador M. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Guinjoan, Salvador M. University of Barcelona. Bellvitge Campus. Department of Clinical Sciences; España
Fil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Mariana N. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Abstract: Background: Heart rate variability (HRV), a measure of autonomic nervous system activity, has been studied in a number of psychiatric disorders during the resting state but evidence on its circadian patterns in Major Depressive Disorder (MDD) and Borderline Personality Disorder (BPD) is scarce. We sought to identify and differentiate HRV circadian patterns in MDD, BPD and healthy controls (HC) while exploring potential physiological mechanisms associated with mood and emotion dysregulation. Methods: 24-Hour electrocardiographic recordings were obtained from fifty subjects (16 HC, 18 BPD, 16 MDD). HRV was calculated during sleep and wake periods. Associations with mood and affect measures, and with cognitive emotion regulation strategies and self-reported difficulties in emotion regulation (DERS) were examined. Participant’s resilience traits were explored in relation to mood and emotion regulation variables. Results: Lower diurnal measures of HRV (i.e, RMSSD and HF) were observed in MDD subjects compared to HCs. Decreased HF was observed during wake vs. sleep in MDD patients. HAM-D and negative affect scores negatively correlated with HRV in MDD and BPD respectively. MDD and BPD exhibited a positive relationship between the implementation of emotion regulation strategies and HRV compared to HC. Increased resilience was associated with lower HAM-D and DERS scores in BPD and HC. Conclusion: HRV alterations characterized by low diurnal cardiac parasympathetic control constitute a potential trait biomarker of major depression and psychiatric vulnerability to depressive episodes in BPD. HRV anomalies in MDD may persist during clinical remission. Diurnal HRV may represent a psychophysiological index of mood and emotion regulation.
description Fil: Wainsztein, Agustina E. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/14232
2468-1717
10.1016/j.pmip.2020.100065
Wainsztein, A.E., et al. Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder [en línea]. Personalized Medicine in Psychiatry. 2020, 23-24 doi:10.1016/j.pmip.2020.100065 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14232
url https://repositorio.uca.edu.ar/handle/123456789/14232
identifier_str_mv 2468-1717
10.1016/j.pmip.2020.100065
Wainsztein, A.E., et al. Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in major depression and borderline personality disorder [en línea]. Personalized Medicine in Psychiatry. 2020, 23-24 doi:10.1016/j.pmip.2020.100065 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14232
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Personalized Medicine in Psychiatry. 2020, 23-24
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
_version_ 1836638362565345280
score 13.13397

Publicaciones similares