Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model

Autores
Romanazzi Chumbita, Lucas; Reati, Carolina; Fontanetti, Pablo Alejandro; Interlandi, Victoria; Centeno, Viviana Andrea
Año de publicación
2016
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Reati, Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina.
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Depending on the dose and the way of administration, fluoride (F-) produces different physico-chemicals and biological effects on bone tissue. The F- biodisponibility is higher when it is administrated as sodium monofluorphosphate (MFP) compared to sodium fluoride (NaF) at equivalent doses. OBJECTIVE: to compare the effect produced by F- administratio n in the form of NaF or MFP, post first molar extraction, on biochemicals markers of phosphocalcic metabolism and morphometric parameters of mandibular growth. METHODS: the first right lower molar of twelve 21-days-old male Wistar rats was extracted under anesthesia. Then, rats were divided into three experimental groups which received distilled water (control) or a solution containing 80 mmol of NaF or MFP per day during 21 days. The treatment was administrated by orogastric catheter. After treatment, animals were euthanized by cervical dislocation and mandibles were collected. Plasma Ca and P levels and alkaline phosphatase (ALP) activity were determined. Morphometric parameters of mandible growth were measured on digital radiographic images using the software Romexis. Data were analyzed by ANOVA and Bonferroni?s post hoc test. RESULTS: Phosphatemia increased in animals under F- treatment respect control animals (p<0,05); an increase in ALP activity was observed o nly in NaF group compared to control (p<0,05). The F- treatment, d! id not affect mandible growth parameters. CONCLUSIONS: the administration of F-, as NaF or MFP, by orogastric catheter after first molar extraction, affected some plasma markers related with phosphocalcic metabolism, effect more pronounced in NaF group.
Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Reati, Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina.
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Otras Ciencias de la Salud
Materia
Monofluorphosfate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/548375
Acceder
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oai_identifier_str oai:rdu.unc.edu.ar:11086/548375
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental modelRomanazzi Chumbita, LucasReati, CarolinaFontanetti, Pablo AlejandroInterlandi, VictoriaCenteno, Viviana AndreaMonofluorphosfateFil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.Fil: Reati, Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina.Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.Depending on the dose and the way of administration, fluoride (F-) produces different physico-chemicals and biological effects on bone tissue. The F- biodisponibility is higher when it is administrated as sodium monofluorphosphate (MFP) compared to sodium fluoride (NaF) at equivalent doses. OBJECTIVE: to compare the effect produced by F- administratio n in the form of NaF or MFP, post first molar extraction, on biochemicals markers of phosphocalcic metabolism and morphometric parameters of mandibular growth. METHODS: the first right lower molar of twelve 21-days-old male Wistar rats was extracted under anesthesia. Then, rats were divided into three experimental groups which received distilled water (control) or a solution containing 80 mmol of NaF or MFP per day during 21 days. The treatment was administrated by orogastric catheter. After treatment, animals were euthanized by cervical dislocation and mandibles were collected. Plasma Ca and P levels and alkaline phosphatase (ALP) activity were determined. Morphometric parameters of mandible growth were measured on digital radiographic images using the software Romexis. Data were analyzed by ANOVA and Bonferroni?s post hoc test. RESULTS: Phosphatemia increased in animals under F- treatment respect control animals (p<0,05); an increase in ALP activity was observed o nly in NaF group compared to control (p<0,05). The F- treatment, d! id not affect mandible growth parameters. CONCLUSIONS: the administration of F-, as NaF or MFP, by orogastric catheter after first molar extraction, affected some plasma markers related with phosphocalcic metabolism, effect more pronounced in NaF group.Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.Fil: Reati, Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina.Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.Otras Ciencias de la Salud2016info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/548375enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-23T11:17:00Zoai:rdu.unc.edu.ar:11086/548375Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-23 11:17:00.928Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model
title Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model
spellingShingle Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model
Romanazzi Chumbita, Lucas
Monofluorphosfate
title_short Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model
title_full Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model
title_fullStr Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model
title_full_unstemmed Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model
title_sort Effect of sodium fluoride or sodium monofluorphosphate treatment in an alveolar bone healing experimental model
dc.creator.none.fl_str_mv Romanazzi Chumbita, Lucas
Reati, Carolina
Fontanetti, Pablo Alejandro
Interlandi, Victoria
Centeno, Viviana Andrea
author Romanazzi Chumbita, Lucas
author_facet Romanazzi Chumbita, Lucas
Reati, Carolina
Fontanetti, Pablo Alejandro
Interlandi, Victoria
Centeno, Viviana Andrea
author_role author
author2 Reati, Carolina
Fontanetti, Pablo Alejandro
Interlandi, Victoria
Centeno, Viviana Andrea
author2_role author
author
author
author
dc.subject.none.fl_str_mv Monofluorphosfate
topic Monofluorphosfate
dc.description.none.fl_txt_mv Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Reati, Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina.
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Depending on the dose and the way of administration, fluoride (F-) produces different physico-chemicals and biological effects on bone tissue. The F- biodisponibility is higher when it is administrated as sodium monofluorphosphate (MFP) compared to sodium fluoride (NaF) at equivalent doses. OBJECTIVE: to compare the effect produced by F- administratio n in the form of NaF or MFP, post first molar extraction, on biochemicals markers of phosphocalcic metabolism and morphometric parameters of mandibular growth. METHODS: the first right lower molar of twelve 21-days-old male Wistar rats was extracted under anesthesia. Then, rats were divided into three experimental groups which received distilled water (control) or a solution containing 80 mmol of NaF or MFP per day during 21 days. The treatment was administrated by orogastric catheter. After treatment, animals were euthanized by cervical dislocation and mandibles were collected. Plasma Ca and P levels and alkaline phosphatase (ALP) activity were determined. Morphometric parameters of mandible growth were measured on digital radiographic images using the software Romexis. Data were analyzed by ANOVA and Bonferroni?s post hoc test. RESULTS: Phosphatemia increased in animals under F- treatment respect control animals (p<0,05); an increase in ALP activity was observed o nly in NaF group compared to control (p<0,05). The F- treatment, d! id not affect mandible growth parameters. CONCLUSIONS: the administration of F-, as NaF or MFP, by orogastric catheter after first molar extraction, affected some plasma markers related with phosphocalcic metabolism, effect more pronounced in NaF group.
Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Reati, Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Fontanetti, Pablo Alejandro. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Introducción a la Química y Física Biológicas A; Argentina.
Fil: Interlandi, Victoria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Fil: Centeno, Viviana Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
Otras Ciencias de la Salud
description Fil: Romanazzi Chumbita, Lucas. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Química Biológica A; Argentina.
publishDate 2016
dc.date.none.fl_str_mv 2016
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dc.identifier.none.fl_str_mv http://hdl.handle.net/11086/548375
url http://hdl.handle.net/11086/548375
dc.language.none.fl_str_mv eng
language eng
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instname_str Universidad Nacional de Córdoba
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