Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout

Autores
Ausas, María Soledad; Mazzitelli Fuentes, Laura; Roman, Fernanda Ruth; Crichigno, Sonia Alejandra; De Vincenti, Ana Paula; Mongiat, Lucas Alberto
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Alterations in the social environment, such as isolating an individual that would normally live in a social group, can generate physiological responses that compromise an individual's capacity to learn. To investigate this, we tested whether social isolation impairs learning skills in the rainbow trout. We show that rainbow trout can achieve an active avoidance (AA) learning program with inter-individual variability. Moreover, c-Fos expression in dorsomedial telencephalon (Dm) correlates with the AA performance, indicating that this structure is involved in this cognitive task. Given that Dm participates in AA learning and this region is under plastic remodelling by addition of new-born neurons, we tested whether social isolation impinges on adult neurogenesis and, consequently, on the Dm cognitive outcome. Trout were reared for four weeks in control or isolated conditions. We found that social isolation diminished the percentage of adult-born neurons that are being incorporated into Dm network. Interestingly, the same isolation treatment also induced a severe deficit in the AA performance. Our results demonstrate a structure-to-function relationship between the Dm and the learning ability in an AA task, indicate that social isolation reduces the incorporation of adult-born neurons into Dm, and show that social isolation impairs the Dm-related cognitive function.
Fil: Ausas, María Soledad. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Ausas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.
Fil: Ausas, María Soledad. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.
Fil: Mazzitelli Fuentes, Laura. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Mazzitelli Fuentes, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.
Fil: Mazzitelli Fuentes, Laura. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.
Fil: Roman, Fernanda Ruth. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Roman, Fernanda Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.
Fil: Roman, Fernanda Ruth. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.
Fil: Crichigno, Sonia Alejandra. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Crichigno, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina.
Fil: De Vincenti, Ana Paula. Universidad Nacional de Buenos Aires; Argentina.
Fil: De Vincenti, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología Celular y Neurociencia. Laboratorio de Neurociencia Molecular y Celular; Argentina.
Fil: Mongiat, Lucas Alberto. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Mongiat, Lucas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.
Fil: Mongiat, Lucas Alberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.
Fuente
Physiology & Behavior. Vol. 198 January (2019)
Materia
Oncorhynchus mykiss
Trucha arcoiris
Neurogénesis
Ciencias de la Tierra y Medio Ambiente
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Repositorio Digital Institucional (UNCo)
Institución
Universidad Nacional del Comahue
OAI Identificador
oai:rdi.uncoma.edu.ar:uncomaid/17269
Acceder
id RDIUNCO_864701dfc5c0e19c160d8414606b22b1
oai_identifier_str oai:rdi.uncoma.edu.ar:uncomaid/17269
network_acronym_str RDIUNCO
repository_id_str 7108
network_name_str Repositorio Digital Institucional (UNCo)
spelling Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow troutAusas, María SoledadMazzitelli Fuentes, LauraRoman, Fernanda RuthCrichigno, Sonia AlejandraDe Vincenti, Ana PaulaMongiat, Lucas AlbertoOncorhynchus mykissTrucha arcoirisNeurogénesisCiencias de la Tierra y Medio AmbienteAlterations in the social environment, such as isolating an individual that would normally live in a social group, can generate physiological responses that compromise an individual's capacity to learn. To investigate this, we tested whether social isolation impairs learning skills in the rainbow trout. We show that rainbow trout can achieve an active avoidance (AA) learning program with inter-individual variability. Moreover, c-Fos expression in dorsomedial telencephalon (Dm) correlates with the AA performance, indicating that this structure is involved in this cognitive task. Given that Dm participates in AA learning and this region is under plastic remodelling by addition of new-born neurons, we tested whether social isolation impinges on adult neurogenesis and, consequently, on the Dm cognitive outcome. Trout were reared for four weeks in control or isolated conditions. We found that social isolation diminished the percentage of adult-born neurons that are being incorporated into Dm network. Interestingly, the same isolation treatment also induced a severe deficit in the AA performance. Our results demonstrate a structure-to-function relationship between the Dm and the learning ability in an AA task, indicate that social isolation reduces the incorporation of adult-born neurons into Dm, and show that social isolation impairs the Dm-related cognitive function.Fil: Ausas, María Soledad. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.Fil: Ausas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.Fil: Ausas, María Soledad. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.Fil: Mazzitelli Fuentes, Laura. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.Fil: Mazzitelli Fuentes, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.Fil: Mazzitelli Fuentes, Laura. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.Fil: Roman, Fernanda Ruth. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.Fil: Roman, Fernanda Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.Fil: Roman, Fernanda Ruth. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.Fil: Crichigno, Sonia Alejandra. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.Fil: Crichigno, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina.Fil: De Vincenti, Ana Paula. Universidad Nacional de Buenos Aires; Argentina.Fil: De Vincenti, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología Celular y Neurociencia. Laboratorio de Neurociencia Molecular y Celular; Argentina.Fil: Mongiat, Lucas Alberto. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.Fil: Mongiat, Lucas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.Fil: Mongiat, Lucas Alberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.Elsevier2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdf0031-9384http://rdi.uncoma.edu.ar/handle/uncomaid/17269Physiology & Behavior. Vol. 198 January (2019)reponame:Repositorio Digital Institucional (UNCo)instname:Universidad Nacional del Comahueenghttps://www.sciencedirect.com/science/article/pii/S0031938418308606?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/2025-09-29T14:29:13Zoai:rdi.uncoma.edu.ar:uncomaid/17269instacron:UNCoInstitucionalhttp://rdi.uncoma.edu.ar/Universidad públicaNo correspondehttp://rdi.uncoma.edu.ar/oaimirtha.mateo@biblioteca.uncoma.edu.ar; adriana.acuna@biblioteca.uncoma.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:71082025-09-29 14:29:13.492Repositorio Digital Institucional (UNCo) - Universidad Nacional del Comahuefalse
dc.title.none.fl_str_mv Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
spellingShingle Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
Ausas, María Soledad
Oncorhynchus mykiss
Trucha arcoiris
Neurogénesis
Ciencias de la Tierra y Medio Ambiente
title_short Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_full Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_fullStr Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_full_unstemmed Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_sort Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
dc.creator.none.fl_str_mv Ausas, María Soledad
Mazzitelli Fuentes, Laura
Roman, Fernanda Ruth
Crichigno, Sonia Alejandra
De Vincenti, Ana Paula
Mongiat, Lucas Alberto
author Ausas, María Soledad
author_facet Ausas, María Soledad
Mazzitelli Fuentes, Laura
Roman, Fernanda Ruth
Crichigno, Sonia Alejandra
De Vincenti, Ana Paula
Mongiat, Lucas Alberto
author_role author
author2 Mazzitelli Fuentes, Laura
Roman, Fernanda Ruth
Crichigno, Sonia Alejandra
De Vincenti, Ana Paula
Mongiat, Lucas Alberto
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Oncorhynchus mykiss
Trucha arcoiris
Neurogénesis
Ciencias de la Tierra y Medio Ambiente
topic Oncorhynchus mykiss
Trucha arcoiris
Neurogénesis
Ciencias de la Tierra y Medio Ambiente
dc.description.none.fl_txt_mv Alterations in the social environment, such as isolating an individual that would normally live in a social group, can generate physiological responses that compromise an individual's capacity to learn. To investigate this, we tested whether social isolation impairs learning skills in the rainbow trout. We show that rainbow trout can achieve an active avoidance (AA) learning program with inter-individual variability. Moreover, c-Fos expression in dorsomedial telencephalon (Dm) correlates with the AA performance, indicating that this structure is involved in this cognitive task. Given that Dm participates in AA learning and this region is under plastic remodelling by addition of new-born neurons, we tested whether social isolation impinges on adult neurogenesis and, consequently, on the Dm cognitive outcome. Trout were reared for four weeks in control or isolated conditions. We found that social isolation diminished the percentage of adult-born neurons that are being incorporated into Dm network. Interestingly, the same isolation treatment also induced a severe deficit in the AA performance. Our results demonstrate a structure-to-function relationship between the Dm and the learning ability in an AA task, indicate that social isolation reduces the incorporation of adult-born neurons into Dm, and show that social isolation impairs the Dm-related cognitive function.
Fil: Ausas, María Soledad. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Ausas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.
Fil: Ausas, María Soledad. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.
Fil: Mazzitelli Fuentes, Laura. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Mazzitelli Fuentes, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.
Fil: Mazzitelli Fuentes, Laura. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.
Fil: Roman, Fernanda Ruth. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Roman, Fernanda Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.
Fil: Roman, Fernanda Ruth. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.
Fil: Crichigno, Sonia Alejandra. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Crichigno, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina.
Fil: De Vincenti, Ana Paula. Universidad Nacional de Buenos Aires; Argentina.
Fil: De Vincenti, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología Celular y Neurociencia. Laboratorio de Neurociencia Molecular y Celular; Argentina.
Fil: Mongiat, Lucas Alberto. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.
Fil: Mongiat, Lucas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina.
Fil: Mongiat, Lucas Alberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina.
description Alterations in the social environment, such as isolating an individual that would normally live in a social group, can generate physiological responses that compromise an individual's capacity to learn. To investigate this, we tested whether social isolation impairs learning skills in the rainbow trout. We show that rainbow trout can achieve an active avoidance (AA) learning program with inter-individual variability. Moreover, c-Fos expression in dorsomedial telencephalon (Dm) correlates with the AA performance, indicating that this structure is involved in this cognitive task. Given that Dm participates in AA learning and this region is under plastic remodelling by addition of new-born neurons, we tested whether social isolation impinges on adult neurogenesis and, consequently, on the Dm cognitive outcome. Trout were reared for four weeks in control or isolated conditions. We found that social isolation diminished the percentage of adult-born neurons that are being incorporated into Dm network. Interestingly, the same isolation treatment also induced a severe deficit in the AA performance. Our results demonstrate a structure-to-function relationship between the Dm and the learning ability in an AA task, indicate that social isolation reduces the incorporation of adult-born neurons into Dm, and show that social isolation impairs the Dm-related cognitive function.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv 0031-9384
http://rdi.uncoma.edu.ar/handle/uncomaid/17269
identifier_str_mv 0031-9384
url http://rdi.uncoma.edu.ar/handle/uncomaid/17269
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0031938418308606?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Physiology & Behavior. Vol. 198 January (2019)
reponame:Repositorio Digital Institucional (UNCo)
instname:Universidad Nacional del Comahue
reponame_str Repositorio Digital Institucional (UNCo)
collection Repositorio Digital Institucional (UNCo)
instname_str Universidad Nacional del Comahue
repository.name.fl_str_mv Repositorio Digital Institucional (UNCo) - Universidad Nacional del Comahue
repository.mail.fl_str_mv mirtha.mateo@biblioteca.uncoma.edu.ar; adriana.acuna@biblioteca.uncoma.edu.ar
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score 12.559606

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