Comparative histopathological and immunological study of two field strains of chicken anemia virus
- Autores
- Rimondi, Agustina; Pinto, Silvina; Olivera, Valeria Soledad; Dibarbora, Marina; Perez Filgueira, Daniel Mariano; Craig, María Isabel; Pereda, Ariel Julian
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Infection of poultry with chicken anemia virus (CAV) is implicated in several field problems in broiler flocks due to the immunosuppression generated and, consequently, the increased susceptibility to secondary infections. Recently, we have reported an increased occurrence of clinical cases caused by CAV strains distantly related to those commonly used for vaccination. In order to understand the behavior of two Argentinean CAV strains (CAV-10 and CAV-18) in two-week-old chickens, an immune and histopathological study was performed. Neither mortality nor clinical signs were observed in the infected or control groups. Thymus lobes from chickens infected with both CAV viruses were smaller compared to the negative control group. At 14 days post-infection (dpi), only chickens inoculated with CAV-10 show a severe depletion of lymphocytes in the thymus cortex and in follicles from the bursa of Fabricius. Also thymopoiesis disorders, such as reduction in the percentage of total DP (CD4 + CD8α+) thymocytes and alteration in the percentages of DP subpopulations, were more important in animals inoculated with the CAV-10 than the CAV-18 strain. In addition, only animals infected with CAV-10 show a decrease in CD8αβ splenocytes. Altogether our results show that, although both Argentinean CAV strains produce subclinical infections in chickens causing immunosuppression at 14 dpi, they might differ in their in vivo pathogenicity.
Instituto de Virología
Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Pinto, Silvina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Patología Aviar; Argentina
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina
Fil: Dibarbora, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Craig, María Isabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina
Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina - Fuente
- BMC veterinary research 45 : 102. (2014)
- Materia
-
Chicken Anemia Virus
Chickens
Animal Diseases
Histocytological Analysis
Análisis Histocitológico
Histopathology
Infection
Virus Anemia Pollo
Pollo
Enfermedades de los Animales
Histopatología
Infección
Subclinical Infection
Double Positive Cell
Negative Control Group
Argentina - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/3582
Ver los metadatos del registro completo
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Comparative histopathological and immunological study of two field strains of chicken anemia virusRimondi, AgustinaPinto, SilvinaOlivera, Valeria SoledadDibarbora, MarinaPerez Filgueira, Daniel MarianoCraig, María IsabelPereda, Ariel JulianChicken Anemia VirusChickensAnimal DiseasesHistocytological AnalysisAnálisis HistocitológicoHistopathologyInfectionVirus Anemia PolloPolloEnfermedades de los AnimalesHistopatologíaInfecciónSubclinical InfectionDouble Positive CellNegative Control GroupArgentinaInfection of poultry with chicken anemia virus (CAV) is implicated in several field problems in broiler flocks due to the immunosuppression generated and, consequently, the increased susceptibility to secondary infections. Recently, we have reported an increased occurrence of clinical cases caused by CAV strains distantly related to those commonly used for vaccination. In order to understand the behavior of two Argentinean CAV strains (CAV-10 and CAV-18) in two-week-old chickens, an immune and histopathological study was performed. Neither mortality nor clinical signs were observed in the infected or control groups. Thymus lobes from chickens infected with both CAV viruses were smaller compared to the negative control group. At 14 days post-infection (dpi), only chickens inoculated with CAV-10 show a severe depletion of lymphocytes in the thymus cortex and in follicles from the bursa of Fabricius. Also thymopoiesis disorders, such as reduction in the percentage of total DP (CD4 + CD8α+) thymocytes and alteration in the percentages of DP subpopulations, were more important in animals inoculated with the CAV-10 than the CAV-18 strain. In addition, only animals infected with CAV-10 show a decrease in CD8αβ splenocytes. Altogether our results show that, although both Argentinean CAV strains produce subclinical infections in chickens causing immunosuppression at 14 dpi, they might differ in their in vivo pathogenicity.Instituto de VirologíaFil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Pinto, Silvina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Patología Aviar; ArgentinaFil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; ArgentinaFil: Dibarbora, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Craig, María Isabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; ArgentinaFil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaBioMed Central2018-10-11T17:36:56Z2018-10-11T17:36:56Z2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/3582https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-014-0102-y1297-9716https://doi.org/10.1186/s13567-014-0102-yBMC veterinary research 45 : 102. (2014)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:44:27Zoai:localhost:20.500.12123/3582instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:27.779INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Comparative histopathological and immunological study of two field strains of chicken anemia virus |
title |
Comparative histopathological and immunological study of two field strains of chicken anemia virus |
spellingShingle |
Comparative histopathological and immunological study of two field strains of chicken anemia virus Rimondi, Agustina Chicken Anemia Virus Chickens Animal Diseases Histocytological Analysis Análisis Histocitológico Histopathology Infection Virus Anemia Pollo Pollo Enfermedades de los Animales Histopatología Infección Subclinical Infection Double Positive Cell Negative Control Group Argentina |
title_short |
Comparative histopathological and immunological study of two field strains of chicken anemia virus |
title_full |
Comparative histopathological and immunological study of two field strains of chicken anemia virus |
title_fullStr |
Comparative histopathological and immunological study of two field strains of chicken anemia virus |
title_full_unstemmed |
Comparative histopathological and immunological study of two field strains of chicken anemia virus |
title_sort |
Comparative histopathological and immunological study of two field strains of chicken anemia virus |
dc.creator.none.fl_str_mv |
Rimondi, Agustina Pinto, Silvina Olivera, Valeria Soledad Dibarbora, Marina Perez Filgueira, Daniel Mariano Craig, María Isabel Pereda, Ariel Julian |
author |
Rimondi, Agustina |
author_facet |
Rimondi, Agustina Pinto, Silvina Olivera, Valeria Soledad Dibarbora, Marina Perez Filgueira, Daniel Mariano Craig, María Isabel Pereda, Ariel Julian |
author_role |
author |
author2 |
Pinto, Silvina Olivera, Valeria Soledad Dibarbora, Marina Perez Filgueira, Daniel Mariano Craig, María Isabel Pereda, Ariel Julian |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Chicken Anemia Virus Chickens Animal Diseases Histocytological Analysis Análisis Histocitológico Histopathology Infection Virus Anemia Pollo Pollo Enfermedades de los Animales Histopatología Infección Subclinical Infection Double Positive Cell Negative Control Group Argentina |
topic |
Chicken Anemia Virus Chickens Animal Diseases Histocytological Analysis Análisis Histocitológico Histopathology Infection Virus Anemia Pollo Pollo Enfermedades de los Animales Histopatología Infección Subclinical Infection Double Positive Cell Negative Control Group Argentina |
dc.description.none.fl_txt_mv |
Infection of poultry with chicken anemia virus (CAV) is implicated in several field problems in broiler flocks due to the immunosuppression generated and, consequently, the increased susceptibility to secondary infections. Recently, we have reported an increased occurrence of clinical cases caused by CAV strains distantly related to those commonly used for vaccination. In order to understand the behavior of two Argentinean CAV strains (CAV-10 and CAV-18) in two-week-old chickens, an immune and histopathological study was performed. Neither mortality nor clinical signs were observed in the infected or control groups. Thymus lobes from chickens infected with both CAV viruses were smaller compared to the negative control group. At 14 days post-infection (dpi), only chickens inoculated with CAV-10 show a severe depletion of lymphocytes in the thymus cortex and in follicles from the bursa of Fabricius. Also thymopoiesis disorders, such as reduction in the percentage of total DP (CD4 + CD8α+) thymocytes and alteration in the percentages of DP subpopulations, were more important in animals inoculated with the CAV-10 than the CAV-18 strain. In addition, only animals infected with CAV-10 show a decrease in CD8αβ splenocytes. Altogether our results show that, although both Argentinean CAV strains produce subclinical infections in chickens causing immunosuppression at 14 dpi, they might differ in their in vivo pathogenicity. Instituto de Virología Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Pinto, Silvina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Patología Aviar; Argentina Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina Fil: Dibarbora, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Craig, María Isabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Laboratorio de Aves y Porcinos; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina |
description |
Infection of poultry with chicken anemia virus (CAV) is implicated in several field problems in broiler flocks due to the immunosuppression generated and, consequently, the increased susceptibility to secondary infections. Recently, we have reported an increased occurrence of clinical cases caused by CAV strains distantly related to those commonly used for vaccination. In order to understand the behavior of two Argentinean CAV strains (CAV-10 and CAV-18) in two-week-old chickens, an immune and histopathological study was performed. Neither mortality nor clinical signs were observed in the infected or control groups. Thymus lobes from chickens infected with both CAV viruses were smaller compared to the negative control group. At 14 days post-infection (dpi), only chickens inoculated with CAV-10 show a severe depletion of lymphocytes in the thymus cortex and in follicles from the bursa of Fabricius. Also thymopoiesis disorders, such as reduction in the percentage of total DP (CD4 + CD8α+) thymocytes and alteration in the percentages of DP subpopulations, were more important in animals inoculated with the CAV-10 than the CAV-18 strain. In addition, only animals infected with CAV-10 show a decrease in CD8αβ splenocytes. Altogether our results show that, although both Argentinean CAV strains produce subclinical infections in chickens causing immunosuppression at 14 dpi, they might differ in their in vivo pathogenicity. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10 2018-10-11T17:36:56Z 2018-10-11T17:36:56Z |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/3582 https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-014-0102-y 1297-9716 https://doi.org/10.1186/s13567-014-0102-y |
url |
http://hdl.handle.net/20.500.12123/3582 https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-014-0102-y https://doi.org/10.1186/s13567-014-0102-y |
identifier_str_mv |
1297-9716 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.none.fl_str_mv |
BMC veterinary research 45 : 102. (2014) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
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INTA Digital (INTA) |
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Instituto Nacional de Tecnología Agropecuaria |
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INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
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tripaldi.nicolas@inta.gob.ar |
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12.559606 |