Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle

Autores
Miraglia, Maria Cruz; Barrios-Benito, Melanie; Galdo Novo, Sabrina; Bucafusco, Danilo; Taffarel, Ana; Capozzo, Alejandra; Borca, Manuel Victor; Perez Filgueira, Daniel Mariano
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vaccine schemes against serotype O strains was studied, evaluating the impact of revaccination, antigen dose, and incorporation of additional FMDV serotypes. Naïve cattle were immunized with seven distinct FMDV vaccines, receiving three doses of the same formulation at 0, 28, and 56 days post-primary vaccination (dpv). Serum samples were collected up to 70 dpv and tested by a virus-neutralizing test against serotype O strains from a South American lineage and two strains representative of two Asian lineages. Our results showed that vaccines containing the ME-SA topotype O1/Campos strain developed cross-neutralizing responses against the two Asian viruses after the first vaccination. In contrast, significant heterotypic neutralizing antibody titers against the homologous topotype strain were only found after the second vaccination, indicating that the phylogenic relationship may differ from the antigenic profiles for these two viruses. The amount of the O1/Campos strain and the revaccination were essential factors for neutralization against the homologous- and heterologous-type O FMDV viruses. The strain composition of the vaccine was only relevant for cross-neutralization against one of the Asian strains, suggesting potential intra-serotypic divergences for this pattern. Keywords: foot-and-mouth disease; cattle; heterologous protection
Instituto de Virología
Fil: Miraglia, Maria Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Miraglia, Maria Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrios-Benito, Melanie. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentina
Fil: Galdo Novo, Sabrina. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentina
Fil: Bucafusco, Danilo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Virología; Argentina
Fil: Bucafusco, Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bucafusco, Danilo. Universidad de Buenos Aires. Instituto de Investigaciones en Producción Animal; Argentina
Fil: Taffarel, Ana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Taffarel, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capozzo, Alejandra. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS); Argentina
Fil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Borca, Manuel Victor. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados Unidos
Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Perez Filgueira, Daniel Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Viruses 16 (11) : 1732 (November 2024)
Materia
Foot-and-mouth Disease
Cattle
Immunization
Neutralization
Serotypes
Fiebre Aftosa
Ganado Bovino
Inmunización
Neutralización
Serotipos
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/20461
Acceder
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oai_identifier_str oai:localhost:20.500.12123/20461
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattleMiraglia, Maria CruzBarrios-Benito, MelanieGaldo Novo, SabrinaBucafusco, DaniloTaffarel, AnaCapozzo, AlejandraBorca, Manuel VictorPerez Filgueira, Daniel MarianoFoot-and-mouth DiseaseCattleImmunizationNeutralizationSerotypesFiebre AftosaGanado BovinoInmunizaciónNeutralizaciónSerotiposThe high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vaccine schemes against serotype O strains was studied, evaluating the impact of revaccination, antigen dose, and incorporation of additional FMDV serotypes. Naïve cattle were immunized with seven distinct FMDV vaccines, receiving three doses of the same formulation at 0, 28, and 56 days post-primary vaccination (dpv). Serum samples were collected up to 70 dpv and tested by a virus-neutralizing test against serotype O strains from a South American lineage and two strains representative of two Asian lineages. Our results showed that vaccines containing the ME-SA topotype O1/Campos strain developed cross-neutralizing responses against the two Asian viruses after the first vaccination. In contrast, significant heterotypic neutralizing antibody titers against the homologous topotype strain were only found after the second vaccination, indicating that the phylogenic relationship may differ from the antigenic profiles for these two viruses. The amount of the O1/Campos strain and the revaccination were essential factors for neutralization against the homologous- and heterologous-type O FMDV viruses. The strain composition of the vaccine was only relevant for cross-neutralization against one of the Asian strains, suggesting potential intra-serotypic divergences for this pattern. Keywords: foot-and-mouth disease; cattle; heterologous protectionInstituto de VirologíaFil: Miraglia, Maria Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Miraglia, Maria Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barrios-Benito, Melanie. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); ArgentinaFil: Galdo Novo, Sabrina. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); ArgentinaFil: Bucafusco, Danilo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Virología; ArgentinaFil: Bucafusco, Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bucafusco, Danilo. Universidad de Buenos Aires. Instituto de Investigaciones en Producción Animal; ArgentinaFil: Taffarel, Ana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Taffarel, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capozzo, Alejandra. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS); ArgentinaFil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Borca, Manuel Victor. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados UnidosFil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Perez Filgueira, Daniel Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMDPI2024-12-04T11:35:20Z2024-12-04T11:35:20Z2024-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/20461https://www.mdpi.com/1999-4915/16/11/17321999-4915https://doi.org/10.3390/v16111732Viruses 16 (11) : 1732 (November 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2023-PD-L01-I113, Herramientas de estudio de la Patogenia e Inmunidad en agentes infecciosos y tóxicos que aporten a la sustentabilidad de la producción pecuaria en el marco de Una Saludinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:46:59Zoai:localhost:20.500.12123/20461instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:47:00.24INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
title Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
spellingShingle Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
Miraglia, Maria Cruz
Foot-and-mouth Disease
Cattle
Immunization
Neutralization
Serotypes
Fiebre Aftosa
Ganado Bovino
Inmunización
Neutralización
Serotipos
title_short Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
title_full Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
title_fullStr Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
title_full_unstemmed Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
title_sort Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
dc.creator.none.fl_str_mv Miraglia, Maria Cruz
Barrios-Benito, Melanie
Galdo Novo, Sabrina
Bucafusco, Danilo
Taffarel, Ana
Capozzo, Alejandra
Borca, Manuel Victor
Perez Filgueira, Daniel Mariano
author Miraglia, Maria Cruz
author_facet Miraglia, Maria Cruz
Barrios-Benito, Melanie
Galdo Novo, Sabrina
Bucafusco, Danilo
Taffarel, Ana
Capozzo, Alejandra
Borca, Manuel Victor
Perez Filgueira, Daniel Mariano
author_role author
author2 Barrios-Benito, Melanie
Galdo Novo, Sabrina
Bucafusco, Danilo
Taffarel, Ana
Capozzo, Alejandra
Borca, Manuel Victor
Perez Filgueira, Daniel Mariano
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Foot-and-mouth Disease
Cattle
Immunization
Neutralization
Serotypes
Fiebre Aftosa
Ganado Bovino
Inmunización
Neutralización
Serotipos
topic Foot-and-mouth Disease
Cattle
Immunization
Neutralization
Serotypes
Fiebre Aftosa
Ganado Bovino
Inmunización
Neutralización
Serotipos
dc.description.none.fl_txt_mv The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vaccine schemes against serotype O strains was studied, evaluating the impact of revaccination, antigen dose, and incorporation of additional FMDV serotypes. Naïve cattle were immunized with seven distinct FMDV vaccines, receiving three doses of the same formulation at 0, 28, and 56 days post-primary vaccination (dpv). Serum samples were collected up to 70 dpv and tested by a virus-neutralizing test against serotype O strains from a South American lineage and two strains representative of two Asian lineages. Our results showed that vaccines containing the ME-SA topotype O1/Campos strain developed cross-neutralizing responses against the two Asian viruses after the first vaccination. In contrast, significant heterotypic neutralizing antibody titers against the homologous topotype strain were only found after the second vaccination, indicating that the phylogenic relationship may differ from the antigenic profiles for these two viruses. The amount of the O1/Campos strain and the revaccination were essential factors for neutralization against the homologous- and heterologous-type O FMDV viruses. The strain composition of the vaccine was only relevant for cross-neutralization against one of the Asian strains, suggesting potential intra-serotypic divergences for this pattern. Keywords: foot-and-mouth disease; cattle; heterologous protection
Instituto de Virología
Fil: Miraglia, Maria Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Miraglia, Maria Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrios-Benito, Melanie. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentina
Fil: Galdo Novo, Sabrina. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentina
Fil: Bucafusco, Danilo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Virología; Argentina
Fil: Bucafusco, Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bucafusco, Danilo. Universidad de Buenos Aires. Instituto de Investigaciones en Producción Animal; Argentina
Fil: Taffarel, Ana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Taffarel, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capozzo, Alejandra. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS); Argentina
Fil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Borca, Manuel Victor. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados Unidos
Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Perez Filgueira, Daniel Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vaccine schemes against serotype O strains was studied, evaluating the impact of revaccination, antigen dose, and incorporation of additional FMDV serotypes. Naïve cattle were immunized with seven distinct FMDV vaccines, receiving three doses of the same formulation at 0, 28, and 56 days post-primary vaccination (dpv). Serum samples were collected up to 70 dpv and tested by a virus-neutralizing test against serotype O strains from a South American lineage and two strains representative of two Asian lineages. Our results showed that vaccines containing the ME-SA topotype O1/Campos strain developed cross-neutralizing responses against the two Asian viruses after the first vaccination. In contrast, significant heterotypic neutralizing antibody titers against the homologous topotype strain were only found after the second vaccination, indicating that the phylogenic relationship may differ from the antigenic profiles for these two viruses. The amount of the O1/Campos strain and the revaccination were essential factors for neutralization against the homologous- and heterologous-type O FMDV viruses. The strain composition of the vaccine was only relevant for cross-neutralization against one of the Asian strains, suggesting potential intra-serotypic divergences for this pattern. Keywords: foot-and-mouth disease; cattle; heterologous protection
publishDate 2024
dc.date.none.fl_str_mv 2024-12-04T11:35:20Z
2024-12-04T11:35:20Z
2024-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/20461
https://www.mdpi.com/1999-4915/16/11/1732
1999-4915
https://doi.org/10.3390/v16111732
url http://hdl.handle.net/20.500.12123/20461
https://www.mdpi.com/1999-4915/16/11/1732
https://doi.org/10.3390/v16111732
identifier_str_mv 1999-4915
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2023-PD-L01-I113, Herramientas de estudio de la Patogenia e Inmunidad en agentes infecciosos y tóxicos que aporten a la sustentabilidad de la producción pecuaria en el marco de Una Salud
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Viruses 16 (11) : 1732 (November 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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