Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador

Autores
Guerrero-Freire, Mónica Salomé; Ledesma, Yanua; Echeverria, Gustavo; Blanco, Federico Carlos; Waard, Jacobus H. de
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Q fever, caused by the bacterium Coxiella burnetii, is a zoonotic disease that has been largely overlooked despite presenting significant risks to both animal and public health. Although well studied in some countries, in most countries in Latin America, there's a lack of information on C. burnetii infection, its prevalence, and its impact on both livestock and human populations. To address this gap, we conducted a serosurvey among farm workers, cattle, sheep, and dogs on two dairy farms in Ecuador using a commercial ELISA kit. Additionally, we conducted a case-control study in cattle to investigate the association between C. burnetii infection and abortion. The findings revealed that 18 % of farm workers, 30 % of dogs, 25 % of cattle and 2 % of sheep tested positive for Q fever antibodies. Interestingly, no significant association between C. burnetii infection and abortion was observed in cattle (p < 0.05) but a high Neospora caninum seroprevalence indicated a strong link to abortion due to this parasite infection. The results highlight the presence of Q fever in both humans and animals on the surveyed farms, with farm dogs showing the highest seroprevalence. A point of concern arises from the significant prevalence of antibodies detected among farm workers, suggesting a potential history of unconfirmed symptomatic respiratory infections caused by a C. burnetii infection. However, further investigations are necessary to better understand the infection dynamics and its potential implications for public and animal health.
Instituto de Biotecnología
Fil: Guerrero-Freire, Mónica Salomé. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador
Fil: Guerrero-Freire, Mónica Salomé. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina
Fil: Ledesma, Yanua. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador
Fil: Ledesma, Yanua. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina
Fil: Echeverria, Gustavo. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina
Fil: Echeverria, Gustavo. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; Ecuador
Fil: Echeverria, Gustavo. BioGENA. División Investigación y Desarrollo; Ecuador
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); Argentina
Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); Argentina
Fil: Waard, Jacobus H. de. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador
Fuente
One Health 19 : 100939 (Diciembre 2024)
Materia
Fiebre Q
Ganado
Salud pública
Obreros Agrícolas
Ecuador
Coxiella burnetii
Salud Humana
Sanidad Animal
Q fever
Livestock
Public health
Agricultural Workers
Human Health
Animal Health
Seroprevalencia
Seroprevalence
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in EcuadorGuerrero-Freire, Mónica SaloméLedesma, YanuaEcheverria, GustavoBlanco, Federico CarlosWaard, Jacobus H. deFiebre QGanadoSalud públicaObreros AgrícolasEcuadorCoxiella burnetiiSalud HumanaSanidad AnimalQ feverLivestockPublic healthAgricultural WorkersHuman HealthAnimal HealthSeroprevalenciaSeroprevalenceQ fever, caused by the bacterium Coxiella burnetii, is a zoonotic disease that has been largely overlooked despite presenting significant risks to both animal and public health. Although well studied in some countries, in most countries in Latin America, there's a lack of information on C. burnetii infection, its prevalence, and its impact on both livestock and human populations. To address this gap, we conducted a serosurvey among farm workers, cattle, sheep, and dogs on two dairy farms in Ecuador using a commercial ELISA kit. Additionally, we conducted a case-control study in cattle to investigate the association between C. burnetii infection and abortion. The findings revealed that 18 % of farm workers, 30 % of dogs, 25 % of cattle and 2 % of sheep tested positive for Q fever antibodies. Interestingly, no significant association between C. burnetii infection and abortion was observed in cattle (p < 0.05) but a high Neospora caninum seroprevalence indicated a strong link to abortion due to this parasite infection. The results highlight the presence of Q fever in both humans and animals on the surveyed farms, with farm dogs showing the highest seroprevalence. A point of concern arises from the significant prevalence of antibodies detected among farm workers, suggesting a potential history of unconfirmed symptomatic respiratory infections caused by a C. burnetii infection. However, further investigations are necessary to better understand the infection dynamics and its potential implications for public and animal health.Instituto de BiotecnologíaFil: Guerrero-Freire, Mónica Salomé. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; EcuadorFil: Guerrero-Freire, Mónica Salomé. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; ArgentinaFil: Ledesma, Yanua. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; EcuadorFil: Ledesma, Yanua. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; ArgentinaFil: Echeverria, Gustavo. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; ArgentinaFil: Echeverria, Gustavo. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; EcuadorFil: Echeverria, Gustavo. BioGENA. División Investigación y Desarrollo; EcuadorFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); ArgentinaFil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); ArgentinaFil: Waard, Jacobus H. de. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; EcuadorElsevier2025-04-01T12:35:16Z2025-04-01T12:35:16Z2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/21864https://www.sciencedirect.com/science/article/pii/S23527714240026592352-7714https://doi.org/10.1016/j.onehlt.2024.100939One Health 19 : 100939 (Diciembre 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología AgropecuariaengEcuador .......... (nation) (World, South America)1000051info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:47:13Zoai:localhost:20.500.12123/21864instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:47:14.322INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador
title Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador
spellingShingle Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador
Guerrero-Freire, Mónica Salomé
Fiebre Q
Ganado
Salud pública
Obreros Agrícolas
Ecuador
Coxiella burnetii
Salud Humana
Sanidad Animal
Q fever
Livestock
Public health
Agricultural Workers
Human Health
Animal Health
Seroprevalencia
Seroprevalence
title_short Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador
title_full Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador
title_fullStr Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador
title_full_unstemmed Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador
title_sort Shedding light on risk: Seroprevalence of Q fever among farm animals and workers in Ecuador
dc.creator.none.fl_str_mv Guerrero-Freire, Mónica Salomé
Ledesma, Yanua
Echeverria, Gustavo
Blanco, Federico Carlos
Waard, Jacobus H. de
author Guerrero-Freire, Mónica Salomé
author_facet Guerrero-Freire, Mónica Salomé
Ledesma, Yanua
Echeverria, Gustavo
Blanco, Federico Carlos
Waard, Jacobus H. de
author_role author
author2 Ledesma, Yanua
Echeverria, Gustavo
Blanco, Federico Carlos
Waard, Jacobus H. de
author2_role author
author
author
author
dc.subject.none.fl_str_mv Fiebre Q
Ganado
Salud pública
Obreros Agrícolas
Ecuador
Coxiella burnetii
Salud Humana
Sanidad Animal
Q fever
Livestock
Public health
Agricultural Workers
Human Health
Animal Health
Seroprevalencia
Seroprevalence
topic Fiebre Q
Ganado
Salud pública
Obreros Agrícolas
Ecuador
Coxiella burnetii
Salud Humana
Sanidad Animal
Q fever
Livestock
Public health
Agricultural Workers
Human Health
Animal Health
Seroprevalencia
Seroprevalence
dc.description.none.fl_txt_mv Q fever, caused by the bacterium Coxiella burnetii, is a zoonotic disease that has been largely overlooked despite presenting significant risks to both animal and public health. Although well studied in some countries, in most countries in Latin America, there's a lack of information on C. burnetii infection, its prevalence, and its impact on both livestock and human populations. To address this gap, we conducted a serosurvey among farm workers, cattle, sheep, and dogs on two dairy farms in Ecuador using a commercial ELISA kit. Additionally, we conducted a case-control study in cattle to investigate the association between C. burnetii infection and abortion. The findings revealed that 18 % of farm workers, 30 % of dogs, 25 % of cattle and 2 % of sheep tested positive for Q fever antibodies. Interestingly, no significant association between C. burnetii infection and abortion was observed in cattle (p < 0.05) but a high Neospora caninum seroprevalence indicated a strong link to abortion due to this parasite infection. The results highlight the presence of Q fever in both humans and animals on the surveyed farms, with farm dogs showing the highest seroprevalence. A point of concern arises from the significant prevalence of antibodies detected among farm workers, suggesting a potential history of unconfirmed symptomatic respiratory infections caused by a C. burnetii infection. However, further investigations are necessary to better understand the infection dynamics and its potential implications for public and animal health.
Instituto de Biotecnología
Fil: Guerrero-Freire, Mónica Salomé. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador
Fil: Guerrero-Freire, Mónica Salomé. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina
Fil: Ledesma, Yanua. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador
Fil: Ledesma, Yanua. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina
Fil: Echeverria, Gustavo. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina
Fil: Echeverria, Gustavo. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; Ecuador
Fil: Echeverria, Gustavo. BioGENA. División Investigación y Desarrollo; Ecuador
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); Argentina
Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); Argentina
Fil: Waard, Jacobus H. de. Universidad de las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador
description Q fever, caused by the bacterium Coxiella burnetii, is a zoonotic disease that has been largely overlooked despite presenting significant risks to both animal and public health. Although well studied in some countries, in most countries in Latin America, there's a lack of information on C. burnetii infection, its prevalence, and its impact on both livestock and human populations. To address this gap, we conducted a serosurvey among farm workers, cattle, sheep, and dogs on two dairy farms in Ecuador using a commercial ELISA kit. Additionally, we conducted a case-control study in cattle to investigate the association between C. burnetii infection and abortion. The findings revealed that 18 % of farm workers, 30 % of dogs, 25 % of cattle and 2 % of sheep tested positive for Q fever antibodies. Interestingly, no significant association between C. burnetii infection and abortion was observed in cattle (p < 0.05) but a high Neospora caninum seroprevalence indicated a strong link to abortion due to this parasite infection. The results highlight the presence of Q fever in both humans and animals on the surveyed farms, with farm dogs showing the highest seroprevalence. A point of concern arises from the significant prevalence of antibodies detected among farm workers, suggesting a potential history of unconfirmed symptomatic respiratory infections caused by a C. burnetii infection. However, further investigations are necessary to better understand the infection dynamics and its potential implications for public and animal health.
publishDate 2024
dc.date.none.fl_str_mv 2024-12
2025-04-01T12:35:16Z
2025-04-01T12:35:16Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/21864
https://www.sciencedirect.com/science/article/pii/S2352771424002659
2352-7714
https://doi.org/10.1016/j.onehlt.2024.100939
url http://hdl.handle.net/20.500.12123/21864
https://www.sciencedirect.com/science/article/pii/S2352771424002659
https://doi.org/10.1016/j.onehlt.2024.100939
identifier_str_mv 2352-7714
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Ecuador .......... (nation) (World, South America)
1000051
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv One Health 19 : 100939 (Diciembre 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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