Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine

Autores
Poggio, Thelma Veronica; Jensen, Oscar; Mossello, M.; Iriarte, J.; Avila, Héctor Gabriel; Gertiser, María Laura; Serafino, J.J.; Romero, Sandra Raquel; Echenique, Marcelo Alejandro; Dominguez, D.E.; Barrios, J.R.; Heath, D.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published using a QuilA‐adjuvanted vaccine. Long‐term efficacy was also tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after the beginning of the trial. The serological results for both sheep and llama were similar to those described previously, except that there was a more rapid response after the first vaccination. A third vaccination given after 1 year resulted in a transient boost in serology that lasted for about 12 months, which was similar to results previously described. Sheep challenged after 4 years with three vaccinations presented 84·2% reduction of live cysts counts compared with control group, and after a fourth vaccination prior to challenge, this reduction was 94·7%. The oil‐based vaccine appeared to be bio‐equivalent to the QuilA vaccine.
EEA Abra Pampa
Fil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; Argentina
Fil: Jensen, Oscar. Centro de Investigacion en Zoonosis; Argentina
Fil: Mossello, M.. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; Argentina
Fil: Iriarte, J. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; Argentina
Fil: Avila, Héctor Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Gertiser, María Laura. Centro de Investigacion en Zoonosis; Argentina
Fil: Serafino, J.J. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; Argentina
Fil: Romero, Sandra Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentina
Fil: Echenique, Marcelo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentina
Fil: Dominguez, D. E.. Gobierno de la Provincia de Chubut. Ministerio de Desarrollo Territorial y Sectores Productivos. Subsecretaría de Ganadería y Agricultura. Dirección de Sanidad Animal; Argentina
Fil: Barrios, J.R.. Servicio Nacional de Sanidad Animal (SENASA).cDirección de Sanidad Animal. Oficina Local Puerto Madryn; Argentina
Fil: Heath, D.. AgResearch; Nueva Zelanda
Fuente
Parasite Immunology 38 (8) : 496-502 (August 2016)
Materia
Ovinos
Llama
Echinococcus granulosus
Inmunidad
Vacuna
Serología
Sheep
Llamas
Immunity
Vaccines
Serology
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/2946
Acceder
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oai_identifier_str oai:localhost:20.500.12123/2946
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccinePoggio, Thelma VeronicaJensen, OscarMossello, M.Iriarte, J.Avila, Héctor GabrielGertiser, María LauraSerafino, J.J.Romero, Sandra RaquelEchenique, Marcelo AlejandroDominguez, D.E.Barrios, J.R.Heath, D.OvinosLlamaEchinococcus granulosusInmunidadVacunaSerologíaSheepLlamasImmunityVaccinesSerologyAn oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published using a QuilA‐adjuvanted vaccine. Long‐term efficacy was also tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after the beginning of the trial. The serological results for both sheep and llama were similar to those described previously, except that there was a more rapid response after the first vaccination. A third vaccination given after 1 year resulted in a transient boost in serology that lasted for about 12 months, which was similar to results previously described. Sheep challenged after 4 years with three vaccinations presented 84·2% reduction of live cysts counts compared with control group, and after a fourth vaccination prior to challenge, this reduction was 94·7%. The oil‐based vaccine appeared to be bio‐equivalent to the QuilA vaccine.EEA Abra PampaFil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; ArgentinaFil: Jensen, Oscar. Centro de Investigacion en Zoonosis; ArgentinaFil: Mossello, M.. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; ArgentinaFil: Iriarte, J. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; ArgentinaFil: Avila, Héctor Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Gertiser, María Laura. Centro de Investigacion en Zoonosis; ArgentinaFil: Serafino, J.J. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; ArgentinaFil: Romero, Sandra Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; ArgentinaFil: Echenique, Marcelo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; ArgentinaFil: Dominguez, D. E.. Gobierno de la Provincia de Chubut. Ministerio de Desarrollo Territorial y Sectores Productivos. Subsecretaría de Ganadería y Agricultura. Dirección de Sanidad Animal; ArgentinaFil: Barrios, J.R.. Servicio Nacional de Sanidad Animal (SENASA).cDirección de Sanidad Animal. Oficina Local Puerto Madryn; ArgentinaFil: Heath, D.. AgResearch; Nueva Zelanda2018-08-01T17:24:07Z2018-08-01T17:24:07Z2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12325http://hdl.handle.net/20.500.12123/29460141-98381365-3024https://doi.org/10.1111/pim.12325Parasite Immunology 38 (8) : 496-502 (August 2016)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-16T09:29:15Zoai:localhost:20.500.12123/2946instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:29:15.4INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
title Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
spellingShingle Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
Poggio, Thelma Veronica
Ovinos
Llama
Echinococcus granulosus
Inmunidad
Vacuna
Serología
Sheep
Llamas
Immunity
Vaccines
Serology
title_short Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
title_full Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
title_fullStr Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
title_full_unstemmed Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
title_sort Serology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccine
dc.creator.none.fl_str_mv Poggio, Thelma Veronica
Jensen, Oscar
Mossello, M.
Iriarte, J.
Avila, Héctor Gabriel
Gertiser, María Laura
Serafino, J.J.
Romero, Sandra Raquel
Echenique, Marcelo Alejandro
Dominguez, D.E.
Barrios, J.R.
Heath, D.
author Poggio, Thelma Veronica
author_facet Poggio, Thelma Veronica
Jensen, Oscar
Mossello, M.
Iriarte, J.
Avila, Héctor Gabriel
Gertiser, María Laura
Serafino, J.J.
Romero, Sandra Raquel
Echenique, Marcelo Alejandro
Dominguez, D.E.
Barrios, J.R.
Heath, D.
author_role author
author2 Jensen, Oscar
Mossello, M.
Iriarte, J.
Avila, Héctor Gabriel
Gertiser, María Laura
Serafino, J.J.
Romero, Sandra Raquel
Echenique, Marcelo Alejandro
Dominguez, D.E.
Barrios, J.R.
Heath, D.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ovinos
Llama
Echinococcus granulosus
Inmunidad
Vacuna
Serología
Sheep
Llamas
Immunity
Vaccines
Serology
topic Ovinos
Llama
Echinococcus granulosus
Inmunidad
Vacuna
Serología
Sheep
Llamas
Immunity
Vaccines
Serology
dc.description.none.fl_txt_mv An oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published using a QuilA‐adjuvanted vaccine. Long‐term efficacy was also tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after the beginning of the trial. The serological results for both sheep and llama were similar to those described previously, except that there was a more rapid response after the first vaccination. A third vaccination given after 1 year resulted in a transient boost in serology that lasted for about 12 months, which was similar to results previously described. Sheep challenged after 4 years with three vaccinations presented 84·2% reduction of live cysts counts compared with control group, and after a fourth vaccination prior to challenge, this reduction was 94·7%. The oil‐based vaccine appeared to be bio‐equivalent to the QuilA vaccine.
EEA Abra Pampa
Fil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; Argentina
Fil: Jensen, Oscar. Centro de Investigacion en Zoonosis; Argentina
Fil: Mossello, M.. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; Argentina
Fil: Iriarte, J. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; Argentina
Fil: Avila, Héctor Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Gertiser, María Laura. Centro de Investigacion en Zoonosis; Argentina
Fil: Serafino, J.J. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; Argentina
Fil: Romero, Sandra Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentina
Fil: Echenique, Marcelo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentina
Fil: Dominguez, D. E.. Gobierno de la Provincia de Chubut. Ministerio de Desarrollo Territorial y Sectores Productivos. Subsecretaría de Ganadería y Agricultura. Dirección de Sanidad Animal; Argentina
Fil: Barrios, J.R.. Servicio Nacional de Sanidad Animal (SENASA).cDirección de Sanidad Animal. Oficina Local Puerto Madryn; Argentina
Fil: Heath, D.. AgResearch; Nueva Zelanda
description An oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published using a QuilA‐adjuvanted vaccine. Long‐term efficacy was also tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after the beginning of the trial. The serological results for both sheep and llama were similar to those described previously, except that there was a more rapid response after the first vaccination. A third vaccination given after 1 year resulted in a transient boost in serology that lasted for about 12 months, which was similar to results previously described. Sheep challenged after 4 years with three vaccinations presented 84·2% reduction of live cysts counts compared with control group, and after a fourth vaccination prior to challenge, this reduction was 94·7%. The oil‐based vaccine appeared to be bio‐equivalent to the QuilA vaccine.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
2018-08-01T17:24:07Z
2018-08-01T17:24:07Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12325
http://hdl.handle.net/20.500.12123/2946
0141-9838
1365-3024
https://doi.org/10.1111/pim.12325
url https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12325
http://hdl.handle.net/20.500.12123/2946
https://doi.org/10.1111/pim.12325
identifier_str_mv 0141-9838
1365-3024
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Parasite Immunology 38 (8) : 496-502 (August 2016)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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