Overview of the role of Shiga toxins in porcine edema disease pathogenesis

Autores
Casanova, Natalia Andrea; Redondo, Leandro Martin; Dailoff, Gabriela Cecilia; Arenas, David; Fernandez Miyakawa, Mariano Enrique
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Shiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the animal host. Porcine edema disease is a serious affection which can lead to dead causing great losses of weaned piglets. Stx2e is the most frequent Stx variant found in porcine feces and is considered the key virulence factor involved in the pathogenesis of porcine edema disease. Stx2e binds with higher affinity to Gb4 receptor than to Gb3 which could be due to amino acid changes in B subunit. Moreover, this subtype also binds to Forssman glycosphingolipids conferring upon Stx2e a unique promiscuous recognition feature. Manifestations of edema disease are caused by systemic effects of Stx2e with no significant morphologic changes in enterocytes. Endothelial cell necrosis in the brain is an early event in the pathogenesis of ED caused by Stx2e-producing STEC strains. Further studies are needed to generate techniques and tools which allow to understand the circulation and ecology of STEC strains in pigs even in resistant animals for diagnostic and epidemiological purposes.
Instituto de Patobiología
Fil: Casanova, Natalia Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Redondo, Leandro Martí­n. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Redondo, Leandro Martí­n. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dailoff, Gabriela Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Dailoff, Gabriela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arenas, David. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arenas, David. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica “Houssay”. Laboratorio de Neurofisiopatología; Argentina
Fil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Fernandez Miyakawa, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Toxicon 148 : 149-154 (June 2018)
Materia
Oedema
Pathogenesis
Swine
Edema
Patogénesis
Cerdo
Shiga Toxin
Toxina Shiga
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/16529
Acceder
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oai_identifier_str oai:localhost:20.500.12123/16529
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network_name_str INTA Digital (INTA)
spelling Overview of the role of Shiga toxins in porcine edema disease pathogenesisCasanova, Natalia AndreaRedondo, Leandro MartinDailoff, Gabriela CeciliaArenas, DavidFernandez Miyakawa, Mariano EnriqueOedemaPathogenesisSwineEdemaPatogénesisCerdoShiga ToxinToxina ShigaShiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the animal host. Porcine edema disease is a serious affection which can lead to dead causing great losses of weaned piglets. Stx2e is the most frequent Stx variant found in porcine feces and is considered the key virulence factor involved in the pathogenesis of porcine edema disease. Stx2e binds with higher affinity to Gb4 receptor than to Gb3 which could be due to amino acid changes in B subunit. Moreover, this subtype also binds to Forssman glycosphingolipids conferring upon Stx2e a unique promiscuous recognition feature. Manifestations of edema disease are caused by systemic effects of Stx2e with no significant morphologic changes in enterocytes. Endothelial cell necrosis in the brain is an early event in the pathogenesis of ED caused by Stx2e-producing STEC strains. Further studies are needed to generate techniques and tools which allow to understand the circulation and ecology of STEC strains in pigs even in resistant animals for diagnostic and epidemiological purposes.Instituto de PatobiologíaFil: Casanova, Natalia Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Redondo, Leandro Martí­n. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Redondo, Leandro Martí­n. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dailoff, Gabriela Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Dailoff, Gabriela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arenas, David. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arenas, David. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica “Houssay”. Laboratorio de Neurofisiopatología; ArgentinaFil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Fernandez Miyakawa, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2024-01-11T13:38:02Z2024-01-11T13:38:02Z2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/16529https://www.sciencedirect.com/science/article/pii/S00410101183016120041-0101https://doi.org/10.1016/j.toxicon.2018.04.019Toxicon 148 : 149-154 (June 2018)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-11T10:24:55Zoai:localhost:20.500.12123/16529instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-11 10:24:56.224INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Overview of the role of Shiga toxins in porcine edema disease pathogenesis
title Overview of the role of Shiga toxins in porcine edema disease pathogenesis
spellingShingle Overview of the role of Shiga toxins in porcine edema disease pathogenesis
Casanova, Natalia Andrea
Oedema
Pathogenesis
Swine
Edema
Patogénesis
Cerdo
Shiga Toxin
Toxina Shiga
title_short Overview of the role of Shiga toxins in porcine edema disease pathogenesis
title_full Overview of the role of Shiga toxins in porcine edema disease pathogenesis
title_fullStr Overview of the role of Shiga toxins in porcine edema disease pathogenesis
title_full_unstemmed Overview of the role of Shiga toxins in porcine edema disease pathogenesis
title_sort Overview of the role of Shiga toxins in porcine edema disease pathogenesis
dc.creator.none.fl_str_mv Casanova, Natalia Andrea
Redondo, Leandro Martin
Dailoff, Gabriela Cecilia
Arenas, David
Fernandez Miyakawa, Mariano Enrique
author Casanova, Natalia Andrea
author_facet Casanova, Natalia Andrea
Redondo, Leandro Martin
Dailoff, Gabriela Cecilia
Arenas, David
Fernandez Miyakawa, Mariano Enrique
author_role author
author2 Redondo, Leandro Martin
Dailoff, Gabriela Cecilia
Arenas, David
Fernandez Miyakawa, Mariano Enrique
author2_role author
author
author
author
dc.subject.none.fl_str_mv Oedema
Pathogenesis
Swine
Edema
Patogénesis
Cerdo
Shiga Toxin
Toxina Shiga
topic Oedema
Pathogenesis
Swine
Edema
Patogénesis
Cerdo
Shiga Toxin
Toxina Shiga
dc.description.none.fl_txt_mv Shiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the animal host. Porcine edema disease is a serious affection which can lead to dead causing great losses of weaned piglets. Stx2e is the most frequent Stx variant found in porcine feces and is considered the key virulence factor involved in the pathogenesis of porcine edema disease. Stx2e binds with higher affinity to Gb4 receptor than to Gb3 which could be due to amino acid changes in B subunit. Moreover, this subtype also binds to Forssman glycosphingolipids conferring upon Stx2e a unique promiscuous recognition feature. Manifestations of edema disease are caused by systemic effects of Stx2e with no significant morphologic changes in enterocytes. Endothelial cell necrosis in the brain is an early event in the pathogenesis of ED caused by Stx2e-producing STEC strains. Further studies are needed to generate techniques and tools which allow to understand the circulation and ecology of STEC strains in pigs even in resistant animals for diagnostic and epidemiological purposes.
Instituto de Patobiología
Fil: Casanova, Natalia Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Redondo, Leandro Martí­n. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Redondo, Leandro Martí­n. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dailoff, Gabriela Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Dailoff, Gabriela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arenas, David. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arenas, David. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica “Houssay”. Laboratorio de Neurofisiopatología; Argentina
Fil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Fernandez Miyakawa, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Shiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the animal host. Porcine edema disease is a serious affection which can lead to dead causing great losses of weaned piglets. Stx2e is the most frequent Stx variant found in porcine feces and is considered the key virulence factor involved in the pathogenesis of porcine edema disease. Stx2e binds with higher affinity to Gb4 receptor than to Gb3 which could be due to amino acid changes in B subunit. Moreover, this subtype also binds to Forssman glycosphingolipids conferring upon Stx2e a unique promiscuous recognition feature. Manifestations of edema disease are caused by systemic effects of Stx2e with no significant morphologic changes in enterocytes. Endothelial cell necrosis in the brain is an early event in the pathogenesis of ED caused by Stx2e-producing STEC strains. Further studies are needed to generate techniques and tools which allow to understand the circulation and ecology of STEC strains in pigs even in resistant animals for diagnostic and epidemiological purposes.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
2024-01-11T13:38:02Z
2024-01-11T13:38:02Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/16529
https://www.sciencedirect.com/science/article/pii/S0041010118301612
0041-0101
https://doi.org/10.1016/j.toxicon.2018.04.019
url http://hdl.handle.net/20.500.12123/16529
https://www.sciencedirect.com/science/article/pii/S0041010118301612
https://doi.org/10.1016/j.toxicon.2018.04.019
identifier_str_mv 0041-0101
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Toxicon 148 : 149-154 (June 2018)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.993085

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