Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
- Autores
- de Figueiredo, Paul; Ficht, Thomas A.; Rice-Ficht, Allison C.; Rossetti, Carlos Alberto; Adams, Leslie G.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics.
Instituto de Patobiología
Fil: de Figueiredo, Paul. Texas A&M University. Department of Veterinary Pathobiology; Estados Unidos
Fil: de Figueiredo, Paul. Texas AgriLife Research; Estados Unidos
Fil: de Figueiredo, Paul. Texas A&M University. Norman Borlaug Center; Estados Unidos
Fil: de Figueiredo, Paul. Texas A&M Health Science Center. Department of Microbial Pathogenesis and Immunology; Estados Unidos
Fil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Rice-Ficht, Allison C. Texas A&M University. College of Medicine. Department of Molecular and Cellular Medicine; Estados Unidos
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos - Fuente
- The American Journal of Pathology 185 (6) : 1505-1517 (Junio 2015)
- Materia
-
Pathogenesis
Brucellosis
Patogénesis
Brucelosis
Brucella
Immunobiology
Host–microbe Interactions
Inmunobiología
Interacciones Huésped-microbio - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/12424
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Pathogenesis and immunobiology of brucellosis : review of brucella-host interactionsde Figueiredo, PaulFicht, Thomas A.Rice-Ficht, Allison C.Rossetti, Carlos AlbertoAdams, Leslie G.PathogenesisBrucellosisPatogénesisBrucelosisBrucellaImmunobiologyHost–microbe InteractionsInmunobiologíaInteracciones Huésped-microbioThis review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics.Instituto de PatobiologíaFil: de Figueiredo, Paul. Texas A&M University. Department of Veterinary Pathobiology; Estados UnidosFil: de Figueiredo, Paul. Texas AgriLife Research; Estados UnidosFil: de Figueiredo, Paul. Texas A&M University. Norman Borlaug Center; Estados UnidosFil: de Figueiredo, Paul. Texas A&M Health Science Center. Department of Microbial Pathogenesis and Immunology; Estados UnidosFil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosFil: Rice-Ficht, Allison C. Texas A&M University. College of Medicine. Department of Molecular and Cellular Medicine; Estados UnidosFil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosElsevier2022-07-28T10:22:36Z2022-07-28T10:22:36Z2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/12424https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext1525-2191https://doi.org/10.1016/j.ajpath.2015.03.003The American Journal of Pathology 185 (6) : 1505-1517 (Junio 2015)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:45:38Zoai:localhost:20.500.12123/12424instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:38.683INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
title |
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
spellingShingle |
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions de Figueiredo, Paul Pathogenesis Brucellosis Patogénesis Brucelosis Brucella Immunobiology Host–microbe Interactions Inmunobiología Interacciones Huésped-microbio |
title_short |
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
title_full |
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
title_fullStr |
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
title_full_unstemmed |
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
title_sort |
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
dc.creator.none.fl_str_mv |
de Figueiredo, Paul Ficht, Thomas A. Rice-Ficht, Allison C. Rossetti, Carlos Alberto Adams, Leslie G. |
author |
de Figueiredo, Paul |
author_facet |
de Figueiredo, Paul Ficht, Thomas A. Rice-Ficht, Allison C. Rossetti, Carlos Alberto Adams, Leslie G. |
author_role |
author |
author2 |
Ficht, Thomas A. Rice-Ficht, Allison C. Rossetti, Carlos Alberto Adams, Leslie G. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Pathogenesis Brucellosis Patogénesis Brucelosis Brucella Immunobiology Host–microbe Interactions Inmunobiología Interacciones Huésped-microbio |
topic |
Pathogenesis Brucellosis Patogénesis Brucelosis Brucella Immunobiology Host–microbe Interactions Inmunobiología Interacciones Huésped-microbio |
dc.description.none.fl_txt_mv |
This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics. Instituto de Patobiología Fil: de Figueiredo, Paul. Texas A&M University. Department of Veterinary Pathobiology; Estados Unidos Fil: de Figueiredo, Paul. Texas AgriLife Research; Estados Unidos Fil: de Figueiredo, Paul. Texas A&M University. Norman Borlaug Center; Estados Unidos Fil: de Figueiredo, Paul. Texas A&M Health Science Center. Department of Microbial Pathogenesis and Immunology; Estados Unidos Fil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos Fil: Rice-Ficht, Allison C. Texas A&M University. College of Medicine. Department of Molecular and Cellular Medicine; Estados Unidos Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos |
description |
This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06 2022-07-28T10:22:36Z 2022-07-28T10:22:36Z |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/12424 https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext 1525-2191 https://doi.org/10.1016/j.ajpath.2015.03.003 |
url |
http://hdl.handle.net/20.500.12123/12424 https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext https://doi.org/10.1016/j.ajpath.2015.03.003 |
identifier_str_mv |
1525-2191 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
The American Journal of Pathology 185 (6) : 1505-1517 (Junio 2015) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
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INTA Digital (INTA) |
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INTA Digital (INTA) |
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Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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1844619167303467008 |
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12.559606 |