Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions

Autores
de Figueiredo, Paul; Ficht, Thomas A.; Rice-Ficht, Allison C.; Rossetti, Carlos Alberto; Adams, Leslie G.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics.
Instituto de Patobiología
Fil: de Figueiredo, Paul. Texas A&M University. Department of Veterinary Pathobiology; Estados Unidos
Fil: de Figueiredo, Paul. Texas AgriLife Research; Estados Unidos
Fil: de Figueiredo, Paul. Texas A&M University. Norman Borlaug Center; Estados Unidos
Fil: de Figueiredo, Paul. Texas A&M Health Science Center. Department of Microbial Pathogenesis and Immunology; Estados Unidos
Fil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Rice-Ficht, Allison C. Texas A&M University. College of Medicine. Department of Molecular and Cellular Medicine; Estados Unidos
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fuente
The American Journal of Pathology 185 (6) : 1505-1517 (Junio 2015)
Materia
Pathogenesis
Brucellosis
Patogénesis
Brucelosis
Brucella
Immunobiology
Host–microbe Interactions
Inmunobiología
Interacciones Huésped-microbio
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling Pathogenesis and immunobiology of brucellosis : review of brucella-host interactionsde Figueiredo, PaulFicht, Thomas A.Rice-Ficht, Allison C.Rossetti, Carlos AlbertoAdams, Leslie G.PathogenesisBrucellosisPatogénesisBrucelosisBrucellaImmunobiologyHost–microbe InteractionsInmunobiologíaInteracciones Huésped-microbioThis review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics.Instituto de PatobiologíaFil: de Figueiredo, Paul. Texas A&M University. Department of Veterinary Pathobiology; Estados UnidosFil: de Figueiredo, Paul. Texas AgriLife Research; Estados UnidosFil: de Figueiredo, Paul. Texas A&M University. Norman Borlaug Center; Estados UnidosFil: de Figueiredo, Paul. Texas A&M Health Science Center. Department of Microbial Pathogenesis and Immunology; Estados UnidosFil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosFil: Rice-Ficht, Allison C. Texas A&M University. College of Medicine. Department of Molecular and Cellular Medicine; Estados UnidosFil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosElsevier2022-07-28T10:22:36Z2022-07-28T10:22:36Z2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/12424https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext1525-2191https://doi.org/10.1016/j.ajpath.2015.03.003The American Journal of Pathology 185 (6) : 1505-1517 (Junio 2015)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:30:50Zoai:localhost:20.500.12123/12424instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:30:50.631INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
title Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
spellingShingle Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
de Figueiredo, Paul
Pathogenesis
Brucellosis
Patogénesis
Brucelosis
Brucella
Immunobiology
Host–microbe Interactions
Inmunobiología
Interacciones Huésped-microbio
title_short Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
title_full Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
title_fullStr Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
title_full_unstemmed Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
title_sort Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
dc.creator.none.fl_str_mv de Figueiredo, Paul
Ficht, Thomas A.
Rice-Ficht, Allison C.
Rossetti, Carlos Alberto
Adams, Leslie G.
author de Figueiredo, Paul
author_facet de Figueiredo, Paul
Ficht, Thomas A.
Rice-Ficht, Allison C.
Rossetti, Carlos Alberto
Adams, Leslie G.
author_role author
author2 Ficht, Thomas A.
Rice-Ficht, Allison C.
Rossetti, Carlos Alberto
Adams, Leslie G.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Pathogenesis
Brucellosis
Patogénesis
Brucelosis
Brucella
Immunobiology
Host–microbe Interactions
Inmunobiología
Interacciones Huésped-microbio
topic Pathogenesis
Brucellosis
Patogénesis
Brucelosis
Brucella
Immunobiology
Host–microbe Interactions
Inmunobiología
Interacciones Huésped-microbio
dc.description.none.fl_txt_mv This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics.
Instituto de Patobiología
Fil: de Figueiredo, Paul. Texas A&M University. Department of Veterinary Pathobiology; Estados Unidos
Fil: de Figueiredo, Paul. Texas AgriLife Research; Estados Unidos
Fil: de Figueiredo, Paul. Texas A&M University. Norman Borlaug Center; Estados Unidos
Fil: de Figueiredo, Paul. Texas A&M Health Science Center. Department of Microbial Pathogenesis and Immunology; Estados Unidos
Fil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Rice-Ficht, Allison C. Texas A&M University. College of Medicine. Department of Molecular and Cellular Medicine; Estados Unidos
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
description This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
2022-07-28T10:22:36Z
2022-07-28T10:22:36Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/12424
https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext
1525-2191
https://doi.org/10.1016/j.ajpath.2015.03.003
url http://hdl.handle.net/20.500.12123/12424
https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext
https://doi.org/10.1016/j.ajpath.2015.03.003
identifier_str_mv 1525-2191
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv The American Journal of Pathology 185 (6) : 1505-1517 (Junio 2015)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.712165

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