Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission

Autores
Uhart, Marcela M.; Vanstreels, Ralph E. T.; Nelson, Martha I.; Olivera, Valeria Soledad; Campagna, Julieta; Zavattieri, Victoria; Lemey, Philippe; Campagna, Claudio; Falabella, Valeria; Rimondi, Agustina
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
H5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina) at Península Valdés, Argentina, in October 2023. We also report on H5N1 viruses in concurrently dead terns. Our genomic analysis shows that viruses from pinnipeds and terns in Argentina form a distinct clade with marine mammal viruses from Peru, Chile, Brazil and Uruguay. Additionally, these marine mammal clade viruses share an identical set of mammalian adaptation mutations which were also present in tern viruses. Our combined ecological and phylogenetic data support mammal-to-mammal transmission and occasional mammal-to-bird spillover and suggest multinational transmission of H5N1 viruses in mammals. We reflect that H5N1 viruses becoming more evolutionary flexible and adapting to mammals in new ways could have global consequences for wildlife, humans, and/or livestock.
Instituto de Virología
Fil: Uhart, Marcela M. University of California Davis. School of Veterinary Medicine. Karen C. Drayer Wildlife Health Center; Estados Unidos
Fil: Uhart, Marcela M. Southern RightWhale Health Monitoring Program; Argentina
Fil: Vanstreels, Ralph E. T. University of California Davis. School of Veterinary Medicine. Karen C. Drayer Wildlife Health Center; Estados Unidos
Fil: Nelson, Martha I. National Institutes of Health. National Library of Medicine. National Center for Biotechnology Information; Estados Unidos
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Olivera, Valeria Soledad. Consejo Nacional de Investigaciones Científcas y Técnicas; Argentina
Fil: Campagna, Julieta. Wildlife Conservation Society. Argentina Program; Argentina
Fil: Zavattieri, Victoria. Wildlife Conservation Society. Argentina Program; Argentina
Fil: Lemey, Philippe. Laboratory for Clinical and Epidemiological Virology. Rega Institute. Department of Microbiology, Immunology and Transplantation; Bélgica
Fil: Campagna, Claudio. Wildlife Conservation Society. Argentina Program; Argentina
Fil: Falabella, Valeria. Wildlife Conservation Society. Argentina Program; Argentina
Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Rimondi, Agustina. Consejo Nacional de Investigaciones Científcas y Técnicas; Argentina
Fil: Rimondi, Agustina. Robert Koch Institute-Alexander von Humboldt fellowship; Alemania
Fuente
Nature Communications 15 : 9516 (Noviember 2024)
Materia
Influenzavirus
Marine Mammals
Pathogenicity
Disease Outbreaks
Mirounga leonina
Mamífero Marino
Patogenicidad
Brote de Enfermedad
Argentina
Elephant Seals
Elefante Marino
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmissionUhart, Marcela M.Vanstreels, Ralph E. T.Nelson, Martha I.Olivera, Valeria SoledadCampagna, JulietaZavattieri, VictoriaLemey, PhilippeCampagna, ClaudioFalabella, ValeriaRimondi, AgustinaInfluenzavirusMarine MammalsPathogenicityDisease OutbreaksMirounga leoninaMamífero MarinoPatogenicidadBrote de EnfermedadArgentinaElephant SealsElefante MarinoH5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina) at Península Valdés, Argentina, in October 2023. We also report on H5N1 viruses in concurrently dead terns. Our genomic analysis shows that viruses from pinnipeds and terns in Argentina form a distinct clade with marine mammal viruses from Peru, Chile, Brazil and Uruguay. Additionally, these marine mammal clade viruses share an identical set of mammalian adaptation mutations which were also present in tern viruses. Our combined ecological and phylogenetic data support mammal-to-mammal transmission and occasional mammal-to-bird spillover and suggest multinational transmission of H5N1 viruses in mammals. We reflect that H5N1 viruses becoming more evolutionary flexible and adapting to mammals in new ways could have global consequences for wildlife, humans, and/or livestock.Instituto de VirologíaFil: Uhart, Marcela M. University of California Davis. School of Veterinary Medicine. Karen C. Drayer Wildlife Health Center; Estados UnidosFil: Uhart, Marcela M. Southern RightWhale Health Monitoring Program; ArgentinaFil: Vanstreels, Ralph E. T. University of California Davis. School of Veterinary Medicine. Karen C. Drayer Wildlife Health Center; Estados UnidosFil: Nelson, Martha I. National Institutes of Health. National Library of Medicine. National Center for Biotechnology Information; Estados UnidosFil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Olivera, Valeria Soledad. Consejo Nacional de Investigaciones Científcas y Técnicas; ArgentinaFil: Campagna, Julieta. Wildlife Conservation Society. Argentina Program; ArgentinaFil: Zavattieri, Victoria. Wildlife Conservation Society. Argentina Program; ArgentinaFil: Lemey, Philippe. Laboratory for Clinical and Epidemiological Virology. Rega Institute. Department of Microbiology, Immunology and Transplantation; BélgicaFil: Campagna, Claudio. Wildlife Conservation Society. Argentina Program; ArgentinaFil: Falabella, Valeria. Wildlife Conservation Society. Argentina Program; ArgentinaFil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Rimondi, Agustina. Consejo Nacional de Investigaciones Científcas y Técnicas; ArgentinaFil: Rimondi, Agustina. Robert Koch Institute-Alexander von Humboldt fellowship; AlemaniaNature Publishing Group2024-12-04T11:45:07Z2024-12-04T11:45:07Z2024-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/20462https://www.nature.com/articles/s41467-024-53766-52041-1723https://doi.org/10.1038/s41467-024-53766-5Nature Communications 15 : 9516 (Noviember 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2023-PD-L06-I114, Desarrollo y aplicación de métodos diagnósticos y epidemiológicos para la producción pecuaria sustentable y agroalimentaria en humanos con foco en Una Saludinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-11T10:25:29Zoai:localhost:20.500.12123/20462instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-11 10:25:29.276INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
title Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
spellingShingle Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
Uhart, Marcela M.
Influenzavirus
Marine Mammals
Pathogenicity
Disease Outbreaks
Mirounga leonina
Mamífero Marino
Patogenicidad
Brote de Enfermedad
Argentina
Elephant Seals
Elefante Marino
title_short Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
title_full Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
title_fullStr Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
title_full_unstemmed Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
title_sort Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
dc.creator.none.fl_str_mv Uhart, Marcela M.
Vanstreels, Ralph E. T.
Nelson, Martha I.
Olivera, Valeria Soledad
Campagna, Julieta
Zavattieri, Victoria
Lemey, Philippe
Campagna, Claudio
Falabella, Valeria
Rimondi, Agustina
author Uhart, Marcela M.
author_facet Uhart, Marcela M.
Vanstreels, Ralph E. T.
Nelson, Martha I.
Olivera, Valeria Soledad
Campagna, Julieta
Zavattieri, Victoria
Lemey, Philippe
Campagna, Claudio
Falabella, Valeria
Rimondi, Agustina
author_role author
author2 Vanstreels, Ralph E. T.
Nelson, Martha I.
Olivera, Valeria Soledad
Campagna, Julieta
Zavattieri, Victoria
Lemey, Philippe
Campagna, Claudio
Falabella, Valeria
Rimondi, Agustina
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Influenzavirus
Marine Mammals
Pathogenicity
Disease Outbreaks
Mirounga leonina
Mamífero Marino
Patogenicidad
Brote de Enfermedad
Argentina
Elephant Seals
Elefante Marino
topic Influenzavirus
Marine Mammals
Pathogenicity
Disease Outbreaks
Mirounga leonina
Mamífero Marino
Patogenicidad
Brote de Enfermedad
Argentina
Elephant Seals
Elefante Marino
dc.description.none.fl_txt_mv H5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina) at Península Valdés, Argentina, in October 2023. We also report on H5N1 viruses in concurrently dead terns. Our genomic analysis shows that viruses from pinnipeds and terns in Argentina form a distinct clade with marine mammal viruses from Peru, Chile, Brazil and Uruguay. Additionally, these marine mammal clade viruses share an identical set of mammalian adaptation mutations which were also present in tern viruses. Our combined ecological and phylogenetic data support mammal-to-mammal transmission and occasional mammal-to-bird spillover and suggest multinational transmission of H5N1 viruses in mammals. We reflect that H5N1 viruses becoming more evolutionary flexible and adapting to mammals in new ways could have global consequences for wildlife, humans, and/or livestock.
Instituto de Virología
Fil: Uhart, Marcela M. University of California Davis. School of Veterinary Medicine. Karen C. Drayer Wildlife Health Center; Estados Unidos
Fil: Uhart, Marcela M. Southern RightWhale Health Monitoring Program; Argentina
Fil: Vanstreels, Ralph E. T. University of California Davis. School of Veterinary Medicine. Karen C. Drayer Wildlife Health Center; Estados Unidos
Fil: Nelson, Martha I. National Institutes of Health. National Library of Medicine. National Center for Biotechnology Information; Estados Unidos
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Olivera, Valeria Soledad. Consejo Nacional de Investigaciones Científcas y Técnicas; Argentina
Fil: Campagna, Julieta. Wildlife Conservation Society. Argentina Program; Argentina
Fil: Zavattieri, Victoria. Wildlife Conservation Society. Argentina Program; Argentina
Fil: Lemey, Philippe. Laboratory for Clinical and Epidemiological Virology. Rega Institute. Department of Microbiology, Immunology and Transplantation; Bélgica
Fil: Campagna, Claudio. Wildlife Conservation Society. Argentina Program; Argentina
Fil: Falabella, Valeria. Wildlife Conservation Society. Argentina Program; Argentina
Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Rimondi, Agustina. Consejo Nacional de Investigaciones Científcas y Técnicas; Argentina
Fil: Rimondi, Agustina. Robert Koch Institute-Alexander von Humboldt fellowship; Alemania
description H5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina) at Península Valdés, Argentina, in October 2023. We also report on H5N1 viruses in concurrently dead terns. Our genomic analysis shows that viruses from pinnipeds and terns in Argentina form a distinct clade with marine mammal viruses from Peru, Chile, Brazil and Uruguay. Additionally, these marine mammal clade viruses share an identical set of mammalian adaptation mutations which were also present in tern viruses. Our combined ecological and phylogenetic data support mammal-to-mammal transmission and occasional mammal-to-bird spillover and suggest multinational transmission of H5N1 viruses in mammals. We reflect that H5N1 viruses becoming more evolutionary flexible and adapting to mammals in new ways could have global consequences for wildlife, humans, and/or livestock.
publishDate 2024
dc.date.none.fl_str_mv 2024-12-04T11:45:07Z
2024-12-04T11:45:07Z
2024-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/20462
https://www.nature.com/articles/s41467-024-53766-5
2041-1723
https://doi.org/10.1038/s41467-024-53766-5
url http://hdl.handle.net/20.500.12123/20462
https://www.nature.com/articles/s41467-024-53766-5
https://doi.org/10.1038/s41467-024-53766-5
identifier_str_mv 2041-1723
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2023-PD-L06-I114, Desarrollo y aplicación de métodos diagnósticos y epidemiológicos para la producción pecuaria sustentable y agroalimentaria en humanos con foco en Una Salud
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Nature Communications 15 : 9516 (Noviember 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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