Virulence factors of the Mycobacterium tuberculosis complex
- Autores
- Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffre, Andrea; Sabio y Garcia, Julia Veronica; Morbidoni, Hector R.; Santangelo, María De La Paz; Cataldi, Angel Adrian; Bigi, Fabiana
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world.
Instituto de Biotecnología
Fil: Forrellad, Marina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Gioffre, Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Sabio y Garcia, Julia Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Morbidoni, Hector R. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Cátedra de Microbiología; Argentina
Fil: Santangelo, María De La Paz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina.
Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina - Fuente
- Virulence 4 (1) : 3-66 (2013)
- Materia
-
Mycobacterium tuberculosis
Virulencia
Patogenicidad
Control de Enfermedades
Vacuna
Virulence
Pathogenicity
Disease Control
Vaccines - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/4293
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Virulence factors of the Mycobacterium tuberculosis complexForrellad, Marina AndreaKlepp, Laura InesGioffre, AndreaSabio y Garcia, Julia VeronicaMorbidoni, Hector R.Santangelo, María De La PazCataldi, Angel AdrianBigi, FabianaMycobacterium tuberculosisVirulenciaPatogenicidadControl de EnfermedadesVacunaVirulencePathogenicityDisease ControlVaccinesThe Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world.Instituto de BiotecnologíaFil: Forrellad, Marina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Gioffre, Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Sabio y Garcia, Julia Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Morbidoni, Hector R. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Cátedra de Microbiología; ArgentinaFil: Santangelo, María De La Paz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina.Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaTaylor & Francis2019-01-18T13:20:36Z2019-01-18T13:20:36Z2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.tandfonline.com/doi/full/10.4161/viru.22329http://hdl.handle.net/20.500.12123/42932150-55942150-5608https://doi.org/10.4161/viru.22329Virulence 4 (1) : 3-66 (2013)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:44:33Zoai:localhost:20.500.12123/4293instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:33.509INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Virulence factors of the Mycobacterium tuberculosis complex |
title |
Virulence factors of the Mycobacterium tuberculosis complex |
spellingShingle |
Virulence factors of the Mycobacterium tuberculosis complex Forrellad, Marina Andrea Mycobacterium tuberculosis Virulencia Patogenicidad Control de Enfermedades Vacuna Virulence Pathogenicity Disease Control Vaccines |
title_short |
Virulence factors of the Mycobacterium tuberculosis complex |
title_full |
Virulence factors of the Mycobacterium tuberculosis complex |
title_fullStr |
Virulence factors of the Mycobacterium tuberculosis complex |
title_full_unstemmed |
Virulence factors of the Mycobacterium tuberculosis complex |
title_sort |
Virulence factors of the Mycobacterium tuberculosis complex |
dc.creator.none.fl_str_mv |
Forrellad, Marina Andrea Klepp, Laura Ines Gioffre, Andrea Sabio y Garcia, Julia Veronica Morbidoni, Hector R. Santangelo, María De La Paz Cataldi, Angel Adrian Bigi, Fabiana |
author |
Forrellad, Marina Andrea |
author_facet |
Forrellad, Marina Andrea Klepp, Laura Ines Gioffre, Andrea Sabio y Garcia, Julia Veronica Morbidoni, Hector R. Santangelo, María De La Paz Cataldi, Angel Adrian Bigi, Fabiana |
author_role |
author |
author2 |
Klepp, Laura Ines Gioffre, Andrea Sabio y Garcia, Julia Veronica Morbidoni, Hector R. Santangelo, María De La Paz Cataldi, Angel Adrian Bigi, Fabiana |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Mycobacterium tuberculosis Virulencia Patogenicidad Control de Enfermedades Vacuna Virulence Pathogenicity Disease Control Vaccines |
topic |
Mycobacterium tuberculosis Virulencia Patogenicidad Control de Enfermedades Vacuna Virulence Pathogenicity Disease Control Vaccines |
dc.description.none.fl_txt_mv |
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world. Instituto de Biotecnología Fil: Forrellad, Marina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Gioffre, Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Sabio y Garcia, Julia Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Morbidoni, Hector R. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Cátedra de Microbiología; Argentina Fil: Santangelo, María De La Paz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina |
description |
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01 2019-01-18T13:20:36Z 2019-01-18T13:20:36Z |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://www.tandfonline.com/doi/full/10.4161/viru.22329 http://hdl.handle.net/20.500.12123/4293 2150-5594 2150-5608 https://doi.org/10.4161/viru.22329 |
url |
https://www.tandfonline.com/doi/full/10.4161/viru.22329 http://hdl.handle.net/20.500.12123/4293 https://doi.org/10.4161/viru.22329 |
identifier_str_mv |
2150-5594 2150-5608 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
Virulence 4 (1) : 3-66 (2013) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
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INTA Digital (INTA) |
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INTA Digital (INTA) |
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Instituto Nacional de Tecnología Agropecuaria |
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INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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