ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis

Autores
Blanco, Federico Carlos; Soria, Marcelo Abel; Klepp, Laura Ines; Bigi, Fabiana
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.
Instituto de Biotecnología
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fuente
Journal of Molecular Microbiology and Biotechnology 27 (4) : 237-245 (Diciembre 2017)
Materia
Transcription
Cattle
Immune Response
Animal Diseases
Transcripción
Mycobacterium bovis
Ganado Bovino
Respuesta Inmunológica
Tuberculosis
Enfermedades de los Animales
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/3986
Acceder
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spelling ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosisBlanco, Federico CarlosSoria, Marcelo AbelKlepp, Laura InesBigi, FabianaTranscriptionCattleImmune ResponseAnimal DiseasesTranscripciónMycobacterium bovisGanado BovinoRespuesta InmunológicaTuberculosisEnfermedades de los AnimalesBovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.Instituto de BiotecnologíaFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaKarger2018-11-28T15:28:27Z2018-11-28T15:28:27Z2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.karger.com/Article/Abstract/479183http://hdl.handle.net/20.500.12123/39861660-2412https://doi.org/10.1159/000479183Journal of Molecular Microbiology and Biotechnology 27 (4) : 237-245 (Diciembre 2017)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/PNBIO/1131034/AR./Inmunología molecular y genómica funcional aplicadas a interacciones patógeno hospedador de interés pecuario.info:eu-repo/semantics/restrictedAccess2025-09-04T09:47:42Zoai:localhost:20.500.12123/3986instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:47:42.99INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
title ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
spellingShingle ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
Blanco, Federico Carlos
Transcription
Cattle
Immune Response
Animal Diseases
Transcripción
Mycobacterium bovis
Ganado Bovino
Respuesta Inmunológica
Tuberculosis
Enfermedades de los Animales
title_short ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
title_full ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
title_fullStr ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
title_full_unstemmed ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
title_sort ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
dc.creator.none.fl_str_mv Blanco, Federico Carlos
Soria, Marcelo Abel
Klepp, Laura Ines
Bigi, Fabiana
author Blanco, Federico Carlos
author_facet Blanco, Federico Carlos
Soria, Marcelo Abel
Klepp, Laura Ines
Bigi, Fabiana
author_role author
author2 Soria, Marcelo Abel
Klepp, Laura Ines
Bigi, Fabiana
author2_role author
author
author
dc.subject.none.fl_str_mv Transcription
Cattle
Immune Response
Animal Diseases
Transcripción
Mycobacterium bovis
Ganado Bovino
Respuesta Inmunológica
Tuberculosis
Enfermedades de los Animales
topic Transcription
Cattle
Immune Response
Animal Diseases
Transcripción
Mycobacterium bovis
Ganado Bovino
Respuesta Inmunológica
Tuberculosis
Enfermedades de los Animales
dc.description.none.fl_txt_mv Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.
Instituto de Biotecnología
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
description Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.
publishDate 2017
dc.date.none.fl_str_mv 2017-12
2018-11-28T15:28:27Z
2018-11-28T15:28:27Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.karger.com/Article/Abstract/479183
http://hdl.handle.net/20.500.12123/3986
1660-2412
https://doi.org/10.1159/000479183
url https://www.karger.com/Article/Abstract/479183
http://hdl.handle.net/20.500.12123/3986
https://doi.org/10.1159/000479183
identifier_str_mv 1660-2412
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/PNBIO/1131034/AR./Inmunología molecular y genómica funcional aplicadas a interacciones patógeno hospedador de interés pecuario.
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv Journal of Molecular Microbiology and Biotechnology 27 (4) : 237-245 (Diciembre 2017)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.623145

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