Clostridium perfringens type E virulence traits involved in gut colonization

Autores
Redondo, Leandro Martín; Diaz Carrasco, Juan María; Redondo, Enzo Alejandro; Delgado, Fernando Oscar; Fernandez Miyakawa, Mariano Enrique
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment.
Instituto de Patobiología
Fil: Redondo, Leandro Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diaz Carrasco, Juan María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Redondo, Enzo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
PLoS ONE 10 (3) : e0121305. (March 23, 2015)
Materia
Clostridium Perfringens
Virulencia
Enfermedades Gastrointestinales
Bacteriocinas
Enteritis
Virulence
Gastrointestinal Diseases
Bacteriocins
Gut Colonization
Colonización Intestinal
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/4804
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spelling Clostridium perfringens type E virulence traits involved in gut colonizationRedondo, Leandro MartínDiaz Carrasco, Juan MaríaRedondo, Enzo AlejandroDelgado, Fernando OscarFernandez Miyakawa, Mariano EnriqueClostridium PerfringensVirulenciaEnfermedades GastrointestinalesBacteriocinasEnteritisVirulenceGastrointestinal DiseasesBacteriocinsGut ColonizationColonización IntestinalClostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment.Instituto de PatobiologíaFil: Redondo, Leandro Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Diaz Carrasco, Juan María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Redondo, Enzo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPLOS2019-04-03T11:56:38Z2019-04-03T11:56:38Z2015-03-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/4804https://journals.plos.org/plosone/article?id=10.1371/journal.pone.01213051932-6203https://doi.org/10.1371/journal.pone.0121305PLoS ONE 10 (3) : e0121305. (March 23, 2015)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-11-06T09:39:57Zoai:localhost:20.500.12123/4804instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-11-06 09:39:58.149INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Clostridium perfringens type E virulence traits involved in gut colonization
title Clostridium perfringens type E virulence traits involved in gut colonization
spellingShingle Clostridium perfringens type E virulence traits involved in gut colonization
Redondo, Leandro Martín
Clostridium Perfringens
Virulencia
Enfermedades Gastrointestinales
Bacteriocinas
Enteritis
Virulence
Gastrointestinal Diseases
Bacteriocins
Gut Colonization
Colonización Intestinal
title_short Clostridium perfringens type E virulence traits involved in gut colonization
title_full Clostridium perfringens type E virulence traits involved in gut colonization
title_fullStr Clostridium perfringens type E virulence traits involved in gut colonization
title_full_unstemmed Clostridium perfringens type E virulence traits involved in gut colonization
title_sort Clostridium perfringens type E virulence traits involved in gut colonization
dc.creator.none.fl_str_mv Redondo, Leandro Martín
Diaz Carrasco, Juan María
Redondo, Enzo Alejandro
Delgado, Fernando Oscar
Fernandez Miyakawa, Mariano Enrique
author Redondo, Leandro Martín
author_facet Redondo, Leandro Martín
Diaz Carrasco, Juan María
Redondo, Enzo Alejandro
Delgado, Fernando Oscar
Fernandez Miyakawa, Mariano Enrique
author_role author
author2 Diaz Carrasco, Juan María
Redondo, Enzo Alejandro
Delgado, Fernando Oscar
Fernandez Miyakawa, Mariano Enrique
author2_role author
author
author
author
dc.subject.none.fl_str_mv Clostridium Perfringens
Virulencia
Enfermedades Gastrointestinales
Bacteriocinas
Enteritis
Virulence
Gastrointestinal Diseases
Bacteriocins
Gut Colonization
Colonización Intestinal
topic Clostridium Perfringens
Virulencia
Enfermedades Gastrointestinales
Bacteriocinas
Enteritis
Virulence
Gastrointestinal Diseases
Bacteriocins
Gut Colonization
Colonización Intestinal
dc.description.none.fl_txt_mv Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment.
Instituto de Patobiología
Fil: Redondo, Leandro Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diaz Carrasco, Juan María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Redondo, Enzo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-23
2019-04-03T11:56:38Z
2019-04-03T11:56:38Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/4804
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121305
1932-6203
https://doi.org/10.1371/journal.pone.0121305
url http://hdl.handle.net/20.500.12123/4804
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121305
https://doi.org/10.1371/journal.pone.0121305
identifier_str_mv 1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv PLoS ONE 10 (3) : e0121305. (March 23, 2015)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 13.142177

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