Epidemiology of Pig Tuberculosis in Argentina

Autores
Barandiaran, Soledad; Marfil, Maria Jimena; Capobianco, Guillermo; Perez Aguirreburualde, María Sol; Zumarraga, Martin Jose; Eirin, Maria Emilia; Cuerda, Maria Ximena; Winter, Marina; Martinez Vivot, Marcela; Pérez, Andrés Maximiliano; La Sala, Luciano Francisco
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to cattle, largely disregarding other species such as swine and wildlife. According to official services, in Argentina disease prevalence in pigs is comparable to that observed in cattle, suggesting the need for efficient control programs to manage the disease in both species. Additionally, extensive farming systems, which are commonly practiced in Argentina, allow the interaction between livestock and wildlife such as wild boar (Sus scrofa), which is considered a natural host of the disease. Here, we evaluated the bTB pigs- cattle interface, studying the dynamics of M. bovis isolates in the pig population and identifying farm-level epidemiological variables associated with the disease confirmation at slaughterhouses. Additionally, to assess the potential multi-host systems in the transmission of bTB, the molecular characterization of wild boar mycobacterial strains was included in the study, as this interaction has not been previously evaluated in this region. Multivariable logistic regression models were used to assess the association between farm-level epidemiological variables (location, farm size, and co-existence with cattle and goats) and bTB confirmation in pig tuberculosis-like lesions samples. Results showed that when cattle were present, the odds of bTB in pigs decreased 0.3 or 0.6% for every additional sow when cattle were present or absent in the farm, respectively. Pigs shared 60% (18/30) of the genotypes with cattle and wild boar, suggesting transmission at the interface between pigs and cattle and highlighting the potential role of wild boar in bTB maintenance. These results provide novel information about the molecular diversity of M. bovis strains in pigs in Argentina and proposes the potential relevance of a multi-host system in the epidemiology of bTB in the region. The statistical models presented here may be used in the design of a low cost, abattoir-based surveillance program for bTB in the pig industry in Argentina, with potential extension to other settings with similar epidemiological conditions.
Instituto de Biotecnología
Fil: Barandiaran, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Producción Animal; Argentina
Fil: Barandiaran, Soledad. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Marfil, Maria Jimena. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina
Fil: Capobianco, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Matemática de Bahía Blanca; Argentina
Fil: Capobianco, Guillermo. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática de Bahía Blanca; Argentina
Fil: Perez Aguirreburualde, María Sol. University of Minnesota. College of Veterinary Medicine; Estados Unidos
Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Eirin, Maria Emilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Eirin, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuerda, Maria Ximena. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Cuerda, Maria Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Winter, Marina. Universidad Nacional de Río Negro. Centro de Investigaciones y Transferencia de Río Negro; Argentina
Fil: Martinez Vivot, Marcela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina
Fil: Pérez, Andrés Maximiliano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Pérez, Andrés Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: La Sala, Luciano Francisco. Universidad Nacional del Sur. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: La Sala, Luciano Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fuente
Frontiers in Veterinary Science 8 : 693082 (July 2021)
Materia
Enfermedades de los Animales
Cerdo
Epidemiología
Argentina
Animal Diseases
Tuberculosis
Swine
Epidemiology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/11129
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oai_identifier_str oai:localhost:20.500.12123/11129
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spelling Epidemiology of Pig Tuberculosis in ArgentinaBarandiaran, SoledadMarfil, Maria JimenaCapobianco, GuillermoPerez Aguirreburualde, María SolZumarraga, Martin JoseEirin, Maria EmiliaCuerda, Maria XimenaWinter, MarinaMartinez Vivot, MarcelaPérez, Andrés MaximilianoLa Sala, Luciano FranciscoEnfermedades de los AnimalesCerdoEpidemiologíaArgentinaAnimal DiseasesTuberculosisSwineEpidemiologyBovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to cattle, largely disregarding other species such as swine and wildlife. According to official services, in Argentina disease prevalence in pigs is comparable to that observed in cattle, suggesting the need for efficient control programs to manage the disease in both species. Additionally, extensive farming systems, which are commonly practiced in Argentina, allow the interaction between livestock and wildlife such as wild boar (Sus scrofa), which is considered a natural host of the disease. Here, we evaluated the bTB pigs- cattle interface, studying the dynamics of M. bovis isolates in the pig population and identifying farm-level epidemiological variables associated with the disease confirmation at slaughterhouses. Additionally, to assess the potential multi-host systems in the transmission of bTB, the molecular characterization of wild boar mycobacterial strains was included in the study, as this interaction has not been previously evaluated in this region. Multivariable logistic regression models were used to assess the association between farm-level epidemiological variables (location, farm size, and co-existence with cattle and goats) and bTB confirmation in pig tuberculosis-like lesions samples. Results showed that when cattle were present, the odds of bTB in pigs decreased 0.3 or 0.6% for every additional sow when cattle were present or absent in the farm, respectively. Pigs shared 60% (18/30) of the genotypes with cattle and wild boar, suggesting transmission at the interface between pigs and cattle and highlighting the potential role of wild boar in bTB maintenance. These results provide novel information about the molecular diversity of M. bovis strains in pigs in Argentina and proposes the potential relevance of a multi-host system in the epidemiology of bTB in the region. The statistical models presented here may be used in the design of a low cost, abattoir-based surveillance program for bTB in the pig industry in Argentina, with potential extension to other settings with similar epidemiological conditions.Instituto de BiotecnologíaFil: Barandiaran, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Producción Animal; ArgentinaFil: Barandiaran, Soledad. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Marfil, Maria Jimena. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; ArgentinaFil: Capobianco, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Matemática de Bahía Blanca; ArgentinaFil: Capobianco, Guillermo. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática de Bahía Blanca; ArgentinaFil: Perez Aguirreburualde, María Sol. University of Minnesota. College of Veterinary Medicine; Estados UnidosFil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Eirin, Maria Emilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Eirin, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cuerda, Maria Ximena. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Cuerda, Maria Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Winter, Marina. Universidad Nacional de Río Negro. Centro de Investigaciones y Transferencia de Río Negro; ArgentinaFil: Martinez Vivot, Marcela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; ArgentinaFil: Pérez, Andrés Maximiliano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Pérez, Andrés Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: La Sala, Luciano Francisco. Universidad Nacional del Sur. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: La Sala, Luciano Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFrontiers Editorial2022-01-14T15:21:20Z2022-01-14T15:21:20Z2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/11129https://www.frontiersin.org/articles/10.3389/fvets.2021.693082/full2297-1769https://doi.org/10.3389/fvets.2021.693082Frontiers in Veterinary Science 8 : 693082 (July 2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-12-18T09:02:16Zoai:localhost:20.500.12123/11129instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-12-18 09:02:16.367INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Epidemiology of Pig Tuberculosis in Argentina
title Epidemiology of Pig Tuberculosis in Argentina
spellingShingle Epidemiology of Pig Tuberculosis in Argentina
Barandiaran, Soledad
Enfermedades de los Animales
Cerdo
Epidemiología
Argentina
Animal Diseases
Tuberculosis
Swine
Epidemiology
title_short Epidemiology of Pig Tuberculosis in Argentina
title_full Epidemiology of Pig Tuberculosis in Argentina
title_fullStr Epidemiology of Pig Tuberculosis in Argentina
title_full_unstemmed Epidemiology of Pig Tuberculosis in Argentina
title_sort Epidemiology of Pig Tuberculosis in Argentina
dc.creator.none.fl_str_mv Barandiaran, Soledad
Marfil, Maria Jimena
Capobianco, Guillermo
Perez Aguirreburualde, María Sol
Zumarraga, Martin Jose
Eirin, Maria Emilia
Cuerda, Maria Ximena
Winter, Marina
Martinez Vivot, Marcela
Pérez, Andrés Maximiliano
La Sala, Luciano Francisco
author Barandiaran, Soledad
author_facet Barandiaran, Soledad
Marfil, Maria Jimena
Capobianco, Guillermo
Perez Aguirreburualde, María Sol
Zumarraga, Martin Jose
Eirin, Maria Emilia
Cuerda, Maria Ximena
Winter, Marina
Martinez Vivot, Marcela
Pérez, Andrés Maximiliano
La Sala, Luciano Francisco
author_role author
author2 Marfil, Maria Jimena
Capobianco, Guillermo
Perez Aguirreburualde, María Sol
Zumarraga, Martin Jose
Eirin, Maria Emilia
Cuerda, Maria Ximena
Winter, Marina
Martinez Vivot, Marcela
Pérez, Andrés Maximiliano
La Sala, Luciano Francisco
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Enfermedades de los Animales
Cerdo
Epidemiología
Argentina
Animal Diseases
Tuberculosis
Swine
Epidemiology
topic Enfermedades de los Animales
Cerdo
Epidemiología
Argentina
Animal Diseases
Tuberculosis
Swine
Epidemiology
dc.description.none.fl_txt_mv Bovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to cattle, largely disregarding other species such as swine and wildlife. According to official services, in Argentina disease prevalence in pigs is comparable to that observed in cattle, suggesting the need for efficient control programs to manage the disease in both species. Additionally, extensive farming systems, which are commonly practiced in Argentina, allow the interaction between livestock and wildlife such as wild boar (Sus scrofa), which is considered a natural host of the disease. Here, we evaluated the bTB pigs- cattle interface, studying the dynamics of M. bovis isolates in the pig population and identifying farm-level epidemiological variables associated with the disease confirmation at slaughterhouses. Additionally, to assess the potential multi-host systems in the transmission of bTB, the molecular characterization of wild boar mycobacterial strains was included in the study, as this interaction has not been previously evaluated in this region. Multivariable logistic regression models were used to assess the association between farm-level epidemiological variables (location, farm size, and co-existence with cattle and goats) and bTB confirmation in pig tuberculosis-like lesions samples. Results showed that when cattle were present, the odds of bTB in pigs decreased 0.3 or 0.6% for every additional sow when cattle were present or absent in the farm, respectively. Pigs shared 60% (18/30) of the genotypes with cattle and wild boar, suggesting transmission at the interface between pigs and cattle and highlighting the potential role of wild boar in bTB maintenance. These results provide novel information about the molecular diversity of M. bovis strains in pigs in Argentina and proposes the potential relevance of a multi-host system in the epidemiology of bTB in the region. The statistical models presented here may be used in the design of a low cost, abattoir-based surveillance program for bTB in the pig industry in Argentina, with potential extension to other settings with similar epidemiological conditions.
Instituto de Biotecnología
Fil: Barandiaran, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Producción Animal; Argentina
Fil: Barandiaran, Soledad. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Marfil, Maria Jimena. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina
Fil: Capobianco, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Matemática de Bahía Blanca; Argentina
Fil: Capobianco, Guillermo. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática de Bahía Blanca; Argentina
Fil: Perez Aguirreburualde, María Sol. University of Minnesota. College of Veterinary Medicine; Estados Unidos
Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Eirin, Maria Emilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Eirin, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuerda, Maria Ximena. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Cuerda, Maria Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Winter, Marina. Universidad Nacional de Río Negro. Centro de Investigaciones y Transferencia de Río Negro; Argentina
Fil: Martinez Vivot, Marcela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina
Fil: Pérez, Andrés Maximiliano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Pérez, Andrés Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: La Sala, Luciano Francisco. Universidad Nacional del Sur. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: La Sala, Luciano Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
description Bovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to cattle, largely disregarding other species such as swine and wildlife. According to official services, in Argentina disease prevalence in pigs is comparable to that observed in cattle, suggesting the need for efficient control programs to manage the disease in both species. Additionally, extensive farming systems, which are commonly practiced in Argentina, allow the interaction between livestock and wildlife such as wild boar (Sus scrofa), which is considered a natural host of the disease. Here, we evaluated the bTB pigs- cattle interface, studying the dynamics of M. bovis isolates in the pig population and identifying farm-level epidemiological variables associated with the disease confirmation at slaughterhouses. Additionally, to assess the potential multi-host systems in the transmission of bTB, the molecular characterization of wild boar mycobacterial strains was included in the study, as this interaction has not been previously evaluated in this region. Multivariable logistic regression models were used to assess the association between farm-level epidemiological variables (location, farm size, and co-existence with cattle and goats) and bTB confirmation in pig tuberculosis-like lesions samples. Results showed that when cattle were present, the odds of bTB in pigs decreased 0.3 or 0.6% for every additional sow when cattle were present or absent in the farm, respectively. Pigs shared 60% (18/30) of the genotypes with cattle and wild boar, suggesting transmission at the interface between pigs and cattle and highlighting the potential role of wild boar in bTB maintenance. These results provide novel information about the molecular diversity of M. bovis strains in pigs in Argentina and proposes the potential relevance of a multi-host system in the epidemiology of bTB in the region. The statistical models presented here may be used in the design of a low cost, abattoir-based surveillance program for bTB in the pig industry in Argentina, with potential extension to other settings with similar epidemiological conditions.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
2022-01-14T15:21:20Z
2022-01-14T15:21:20Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/11129
https://www.frontiersin.org/articles/10.3389/fvets.2021.693082/full
2297-1769
https://doi.org/10.3389/fvets.2021.693082
url http://hdl.handle.net/20.500.12123/11129
https://www.frontiersin.org/articles/10.3389/fvets.2021.693082/full
https://doi.org/10.3389/fvets.2021.693082
identifier_str_mv 2297-1769
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Editorial
publisher.none.fl_str_mv Frontiers Editorial
dc.source.none.fl_str_mv Frontiers in Veterinary Science 8 : 693082 (July 2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
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repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
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