Vaccines against bovine babesiosis: where we are now and possible roads ahead

Autores
Florin-Christensen, Mónica; Suarez, Carlos Esteban; Rodriguez, Anabel Elisa; Flores, Daniela; Schnittger, Leonhard
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems.
Instituto de Patobiología
Fil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suarez, Carlos Esteban. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Rodriguez, Anabel Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Flores, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. ANPCyT; Argentina
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Parasitology 141 (12) : 1563-1592 (Octubre 2014)
Materia
Babesiosis
Vacuna Viva
Eritrocitos
Enfermedades Transmitidas por Garrapatas
Respuesta Inmunológica
Ganado Bovino
Live Vaccines
Erythrocytes
Tick-borne Diseases
Immune Response
Cattle
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/6712
Acceder
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oai_identifier_str oai:localhost:20.500.12123/6712
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network_name_str INTA Digital (INTA)
spelling Vaccines against bovine babesiosis: where we are now and possible roads aheadFlorin-Christensen, MónicaSuarez, Carlos EstebanRodriguez, Anabel ElisaFlores, DanielaSchnittger, LeonhardBabesiosisVacuna VivaEritrocitosEnfermedades Transmitidas por GarrapatasRespuesta InmunológicaGanado BovinoLive VaccinesErythrocytesTick-borne DiseasesImmune ResponseCattleBovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems.Instituto de PatobiologíaFil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Suarez, Carlos Esteban. Washington State University. Department of Veterinary Microbiology and Pathology; Estados UnidosFil: Rodriguez, Anabel Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Flores, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. ANPCyT; ArgentinaFil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaCambridge University Press2020-02-11T11:08:24Z2020-02-11T11:08:24Z2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/6712https://www.cambridge.org/core/journals/parasitology/article/vaccines-against-bovine-babesiosis-where-we-are-now-and-possible-roads-ahead/AB57CCC9D2E129C420762F66D7A3DF331469-8161https://doi.org/10.1017/S0031182014000961Parasitology 141 (12) : 1563-1592 (Octubre 2014)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-23T11:17:12Zoai:localhost:20.500.12123/6712instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:17:12.636INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Vaccines against bovine babesiosis: where we are now and possible roads ahead
title Vaccines against bovine babesiosis: where we are now and possible roads ahead
spellingShingle Vaccines against bovine babesiosis: where we are now and possible roads ahead
Florin-Christensen, Mónica
Babesiosis
Vacuna Viva
Eritrocitos
Enfermedades Transmitidas por Garrapatas
Respuesta Inmunológica
Ganado Bovino
Live Vaccines
Erythrocytes
Tick-borne Diseases
Immune Response
Cattle
title_short Vaccines against bovine babesiosis: where we are now and possible roads ahead
title_full Vaccines against bovine babesiosis: where we are now and possible roads ahead
title_fullStr Vaccines against bovine babesiosis: where we are now and possible roads ahead
title_full_unstemmed Vaccines against bovine babesiosis: where we are now and possible roads ahead
title_sort Vaccines against bovine babesiosis: where we are now and possible roads ahead
dc.creator.none.fl_str_mv Florin-Christensen, Mónica
Suarez, Carlos Esteban
Rodriguez, Anabel Elisa
Flores, Daniela
Schnittger, Leonhard
author Florin-Christensen, Mónica
author_facet Florin-Christensen, Mónica
Suarez, Carlos Esteban
Rodriguez, Anabel Elisa
Flores, Daniela
Schnittger, Leonhard
author_role author
author2 Suarez, Carlos Esteban
Rodriguez, Anabel Elisa
Flores, Daniela
Schnittger, Leonhard
author2_role author
author
author
author
dc.subject.none.fl_str_mv Babesiosis
Vacuna Viva
Eritrocitos
Enfermedades Transmitidas por Garrapatas
Respuesta Inmunológica
Ganado Bovino
Live Vaccines
Erythrocytes
Tick-borne Diseases
Immune Response
Cattle
topic Babesiosis
Vacuna Viva
Eritrocitos
Enfermedades Transmitidas por Garrapatas
Respuesta Inmunológica
Ganado Bovino
Live Vaccines
Erythrocytes
Tick-borne Diseases
Immune Response
Cattle
dc.description.none.fl_txt_mv Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems.
Instituto de Patobiología
Fil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suarez, Carlos Esteban. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Rodriguez, Anabel Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Flores, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. ANPCyT; Argentina
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems.
publishDate 2014
dc.date.none.fl_str_mv 2014-10
2020-02-11T11:08:24Z
2020-02-11T11:08:24Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/6712
https://www.cambridge.org/core/journals/parasitology/article/vaccines-against-bovine-babesiosis-where-we-are-now-and-possible-roads-ahead/AB57CCC9D2E129C420762F66D7A3DF33
1469-8161
https://doi.org/10.1017/S0031182014000961
url http://hdl.handle.net/20.500.12123/6712
https://www.cambridge.org/core/journals/parasitology/article/vaccines-against-bovine-babesiosis-where-we-are-now-and-possible-roads-ahead/AB57CCC9D2E129C420762F66D7A3DF33
https://doi.org/10.1017/S0031182014000961
identifier_str_mv 1469-8161
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv Parasitology 141 (12) : 1563-1592 (Octubre 2014)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.982451

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