Predictors of surgical complications in boys with hypospadias: data from an international registry

• Autores: Scougall, Kathryn; Bryce, Jillian; Baronio, Federico; Boal, Rachel L.; Castera, Jose Roberto; Castro, Sebastián; Cheetham, Tim; Costa, Eduardo Corrêa; Darendeliler, Feyza; Davies, Justin H.; Dirlewanger, Mirjam; Gazdagh, Gabriella; Globa, Evgenia; Guerra Junior, Gil; Guran, Tulay; Herrmann, Gloria; Holterhus, Paul-Martin; Akgül, Ahsen Karagözlü; Markosyan, Renata; McElreavey, Kenneth; Miranda, Marcio Lopes; Nordenstrom, Anna; O'Toole, Stuart; Poyrazoglu, Sukran; Russo, Gianni; Schwitzgebel, Valerie; Stancampiano, Marianna; Steigert, Michael; Ahmed, S. Faisal; Lucas Herald, Angela K.
• Año de publicación: 2023
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Hypospadias; Complications; Data
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background: Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence. Methods: Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher’s exact tests and spearman’s correlation tests were performed on the data to assess associations between clinical factors and complication rates. Results: Of the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications. Conclusions: Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation.
Fil: Scougall, Kathryn. University of Glasgow; Reino Unido
Fil: Bryce, Jillian. University of Glasgow; Reino Unido
Fil: Baronio, Federico. Universidad de Bologna; Italia
Fil: Boal, Rachel L.. Great North Children's Hospital; Reino Unido
Fil: Castera, Jose Roberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
Fil: Castro, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Cheetham, Tim. Great North Children's Hospital; Reino Unido
Fil: Costa, Eduardo Corrêa. Hospital de Clinicas de Porto Alegre; Brasil
Fil: Darendeliler, Feyza. Istambul University; Turquía
Fil: Davies, Justin H.. Southampton Children's Hospital; Reino Unido
Fil: Dirlewanger, Mirjam. University Hospital of Geneva; Suiza
Fil: Gazdagh, Gabriella. Southampton Children's Hospital; Reino Unido
Fil: Globa, Evgenia. Ukrainian Research Center of Endocrine Surgery Endocrine Organs and Tissue Transplantation; Ucrania
Fil: Guerra Junior, Gil. Universidade Estadual de Campinas; Brasil
Fil: Guran, Tulay. Marmara University; Turquía
Fil: Herrmann, Gloria. University Medical Centre; Alemania
Fil: Holterhus, Paul-Martin. University Hospital of Schleswig-Holstein Campus Kiel; Alemania. Christian-Albrechts-University of Kiel; Alemania
Fil: Akgül, Ahsen Karagözlü. Marmara University. Faculty of Medicine; Turquía
Fil: Markosyan, Renata. Yerevan State Medical University Endocrinology Clinic; Armenia
Fil: McElreavey, Kenneth. Instituto Pasteur; Francia
Fil: Miranda, Marcio Lopes. Universidade Estadual de Campinas; Brasil
Fil: Nordenstrom, Anna. Karolinska Huddinge Hospital; Suecia
Fil: O'Toole, Stuart. Royal Hospital for Children; Reino Unido
Fil: Poyrazoglu, Sukran. Istanbul University; Turquía
Fil: Russo, Gianni. Istituto Nazionale di Ricovero e Cura a Carattere Scientifico "Saverio de Bellis"; Italia
Fil: Schwitzgebel, Valerie. University Hospital of Geneva; Suiza
Fil: Stancampiano, Marianna. Istituto Nazionale di Ricovero e Cura a Carattere Scientifico "Saverio de Bellis"; Italia
Fil: Steigert, Michael. Graubunden Cantonal Hospital; Suiza
Fil: Ahmed, S. Faisal. University of Glasgow; Reino Unido
Fil: Lucas Herald, Angela K.. University of Glasgow; Reino Unido