Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina

Autores
Parada, Julian; Galas, Marcelo Fabián; Faccone, Diego Francisco; Tamiozzo, Pablo Jesus; Carranza, Alicia
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and Aim: Salmonellosis is one of the most common foodborne diseases in the world, and the increasing antibiotic resistance in Salmonella enterica subsp. enterica recovered from food animals constitutes an important risk from a One Health approach. This study aimed to characterize antibiotic resistance and some of its associated resistance determinants in different S. enterica serovars isolated from pigs in Argentina. Materials and Methods: A retrospective study was conducted on Salmonella strains isolated between 2011 and 2015 from pigs in the Pampean region of Argentina. The antimicrobial susceptibility patterns to 21 antimicrobials and some antibiotic resistance determinants were characterized in 55 Salmonella isolates, representing 58 farms. Results: We identified 56% (n=30) of the strains as multidrug-resistant, where resistance to tetracycline (62%, n=34), ampicillin (53%, n=29), nalidixic acid (53%, n=29), chloramphenicol (33%, n=18), and trimethoprim-sulfamethoxazole (31%, n=17) was most common. The wide range of resistance to ampicillin correlates with the presence of TEM type β-lactamases in the strains. However, high susceptibility was found in the new generation of β-lactams. Fluoroquinolone resistance is a major concern. Most strains with decreased susceptibility to ciprofloxacin showed gyrA mutations and plasmid-mediated quinolone resistance gene qnrB. Conclusion: Here, we identified broad resistance to some antibiotics frequently used in human therapeutics and several easily transferable resistance mechanisms that could endanger public health.
Fil: Parada, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Galas, Marcelo Fabián. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina. Pan American Health Organization. Communicable Diseases and Environmental Determinants of Health. Antimicrobial Resistance Special Program; Estados Unidos
Fil: Faccone, Diego Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Tamiozzo, Pablo Jesus. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Carranza, Alicia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Materia
ENVIRONMENT
HEALTH
LIVESTOCK
SALMONELLOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/161338
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/161338
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in ArgentinaParada, JulianGalas, Marcelo FabiánFaccone, Diego FranciscoTamiozzo, Pablo JesusCarranza, AliciaENVIRONMENTHEALTHLIVESTOCKSALMONELLOSIShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Background and Aim: Salmonellosis is one of the most common foodborne diseases in the world, and the increasing antibiotic resistance in Salmonella enterica subsp. enterica recovered from food animals constitutes an important risk from a One Health approach. This study aimed to characterize antibiotic resistance and some of its associated resistance determinants in different S. enterica serovars isolated from pigs in Argentina. Materials and Methods: A retrospective study was conducted on Salmonella strains isolated between 2011 and 2015 from pigs in the Pampean region of Argentina. The antimicrobial susceptibility patterns to 21 antimicrobials and some antibiotic resistance determinants were characterized in 55 Salmonella isolates, representing 58 farms. Results: We identified 56% (n=30) of the strains as multidrug-resistant, where resistance to tetracycline (62%, n=34), ampicillin (53%, n=29), nalidixic acid (53%, n=29), chloramphenicol (33%, n=18), and trimethoprim-sulfamethoxazole (31%, n=17) was most common. The wide range of resistance to ampicillin correlates with the presence of TEM type β-lactamases in the strains. However, high susceptibility was found in the new generation of β-lactams. Fluoroquinolone resistance is a major concern. Most strains with decreased susceptibility to ciprofloxacin showed gyrA mutations and plasmid-mediated quinolone resistance gene qnrB. Conclusion: Here, we identified broad resistance to some antibiotics frequently used in human therapeutics and several easily transferable resistance mechanisms that could endanger public health.Fil: Parada, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Galas, Marcelo Fabián. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina. Pan American Health Organization. Communicable Diseases and Environmental Determinants of Health. Antimicrobial Resistance Special Program; Estados UnidosFil: Faccone, Diego Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Tamiozzo, Pablo Jesus. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Carranza, Alicia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaVeterinary World2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161338Parada, Julian; Galas, Marcelo Fabián; Faccone, Diego Francisco; Tamiozzo, Pablo Jesus; Carranza, Alicia; Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina; Veterinary World; Veterinary World; 15; 5; 5-2022; 1215-12202231-09160972-8988CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.veterinaryworld.org/Vol.15/May-2022/9.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.14202/vetworld.2022.1215-1220info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:33Zoai:ri.conicet.gov.ar:11336/161338instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:33.533CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina
title Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina
spellingShingle Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina
Parada, Julian
ENVIRONMENT
HEALTH
LIVESTOCK
SALMONELLOSIS
title_short Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina
title_full Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina
title_fullStr Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina
title_full_unstemmed Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina
title_sort Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina
dc.creator.none.fl_str_mv Parada, Julian
Galas, Marcelo Fabián
Faccone, Diego Francisco
Tamiozzo, Pablo Jesus
Carranza, Alicia
author Parada, Julian
author_facet Parada, Julian
Galas, Marcelo Fabián
Faccone, Diego Francisco
Tamiozzo, Pablo Jesus
Carranza, Alicia
author_role author
author2 Galas, Marcelo Fabián
Faccone, Diego Francisco
Tamiozzo, Pablo Jesus
Carranza, Alicia
author2_role author
author
author
author
dc.subject.none.fl_str_mv ENVIRONMENT
HEALTH
LIVESTOCK
SALMONELLOSIS
topic ENVIRONMENT
HEALTH
LIVESTOCK
SALMONELLOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Background and Aim: Salmonellosis is one of the most common foodborne diseases in the world, and the increasing antibiotic resistance in Salmonella enterica subsp. enterica recovered from food animals constitutes an important risk from a One Health approach. This study aimed to characterize antibiotic resistance and some of its associated resistance determinants in different S. enterica serovars isolated from pigs in Argentina. Materials and Methods: A retrospective study was conducted on Salmonella strains isolated between 2011 and 2015 from pigs in the Pampean region of Argentina. The antimicrobial susceptibility patterns to 21 antimicrobials and some antibiotic resistance determinants were characterized in 55 Salmonella isolates, representing 58 farms. Results: We identified 56% (n=30) of the strains as multidrug-resistant, where resistance to tetracycline (62%, n=34), ampicillin (53%, n=29), nalidixic acid (53%, n=29), chloramphenicol (33%, n=18), and trimethoprim-sulfamethoxazole (31%, n=17) was most common. The wide range of resistance to ampicillin correlates with the presence of TEM type β-lactamases in the strains. However, high susceptibility was found in the new generation of β-lactams. Fluoroquinolone resistance is a major concern. Most strains with decreased susceptibility to ciprofloxacin showed gyrA mutations and plasmid-mediated quinolone resistance gene qnrB. Conclusion: Here, we identified broad resistance to some antibiotics frequently used in human therapeutics and several easily transferable resistance mechanisms that could endanger public health.
Fil: Parada, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Galas, Marcelo Fabián. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina. Pan American Health Organization. Communicable Diseases and Environmental Determinants of Health. Antimicrobial Resistance Special Program; Estados Unidos
Fil: Faccone, Diego Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Tamiozzo, Pablo Jesus. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Carranza, Alicia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
description Background and Aim: Salmonellosis is one of the most common foodborne diseases in the world, and the increasing antibiotic resistance in Salmonella enterica subsp. enterica recovered from food animals constitutes an important risk from a One Health approach. This study aimed to characterize antibiotic resistance and some of its associated resistance determinants in different S. enterica serovars isolated from pigs in Argentina. Materials and Methods: A retrospective study was conducted on Salmonella strains isolated between 2011 and 2015 from pigs in the Pampean region of Argentina. The antimicrobial susceptibility patterns to 21 antimicrobials and some antibiotic resistance determinants were characterized in 55 Salmonella isolates, representing 58 farms. Results: We identified 56% (n=30) of the strains as multidrug-resistant, where resistance to tetracycline (62%, n=34), ampicillin (53%, n=29), nalidixic acid (53%, n=29), chloramphenicol (33%, n=18), and trimethoprim-sulfamethoxazole (31%, n=17) was most common. The wide range of resistance to ampicillin correlates with the presence of TEM type β-lactamases in the strains. However, high susceptibility was found in the new generation of β-lactams. Fluoroquinolone resistance is a major concern. Most strains with decreased susceptibility to ciprofloxacin showed gyrA mutations and plasmid-mediated quinolone resistance gene qnrB. Conclusion: Here, we identified broad resistance to some antibiotics frequently used in human therapeutics and several easily transferable resistance mechanisms that could endanger public health.
publishDate 2022
dc.date.none.fl_str_mv 2022-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/161338
Parada, Julian; Galas, Marcelo Fabián; Faccone, Diego Francisco; Tamiozzo, Pablo Jesus; Carranza, Alicia; Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina; Veterinary World; Veterinary World; 15; 5; 5-2022; 1215-1220
2231-0916
0972-8988
CONICET Digital
CONICET
url http://hdl.handle.net/11336/161338
identifier_str_mv Parada, Julian; Galas, Marcelo Fabián; Faccone, Diego Francisco; Tamiozzo, Pablo Jesus; Carranza, Alicia; Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina; Veterinary World; Veterinary World; 15; 5; 5-2022; 1215-1220
2231-0916
0972-8988
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.veterinaryworld.org/Vol.15/May-2022/9.html
info:eu-repo/semantics/altIdentifier/doi/10.14202/vetworld.2022.1215-1220
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Veterinary World
publisher.none.fl_str_mv Veterinary World
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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