NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
- Autores
- Lamberti, María Julia; Morales Vasconsuelo, Ana Belen; Chiaramello, Marianela; Ferreira, Vitor Francisco; Macedo Oliveira, Milena; Baptista Ferreira, Sabrina; Rivarola, Viviana Alicia; Rumie Vittar, Natalia Belen
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role in melanogenesis and given its correlation with a poor patient outcome we propose this enzyme as an intriguing target for molecular-based therapeutic regimen against melanoma. Unfortunately, the natural product β-Lapachone (β-Lap), whose antitumor activity is based on NQO1, reported dose-limiting toxicity which hampered its pre-clinical and clinical use. Therefore, new effective and safe therapeutic NQO1-bioactivatable agents for melanoma treatment are desirable. Regarding NQO1, we demonstrated that halogenated β-Lap derivative named PFB is an excellent substrate and effective tumor-selective anticancer compound. In addition, PFB resulted more attractive than the parent β-Lap for treating metastatic-derived melanoma cells. In this context, it would be interesting to design strategies to induce NQO1 activity in cancer cells as a promising combinatorial approach with bioreductive drugs. In this sense, we had reported that photodynamic therapy (PDT) significantly upregulated NQO1 expression. Based on this event, here we demonstrated that the cytotoxic regimen consisting of PFB plus PDT improved synergistic therapeutic combination on melanoma cells. In conclusion, our contribution provides a strong rationale for using therapies that associate photo- and chemotherapy to effectively treat melanoma with modular NQO1 status.
Fil: Lamberti, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Morales Vasconsuelo, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Chiaramello, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Ferreira, Vitor Francisco. Universidade Federal Fluminense; Brasil
Fil: Macedo Oliveira, Milena. Universidade Federal do Rio de Janeiro; Brasil
Fil: Baptista Ferreira, Sabrina. Universidade Federal do Rio de Janeiro; Brasil
Fil: Rivarola, Viviana Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Rumie Vittar, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina - Materia
-
COMBINATORIAL THERAPIES
MELANOMA
NAPHTOQUINONES
NQO1
PHOTODYNAMIC THERAPY
Β-LAPACHONE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/100525
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NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanomaLamberti, María JuliaMorales Vasconsuelo, Ana BelenChiaramello, MarianelaFerreira, Vitor FranciscoMacedo Oliveira, MilenaBaptista Ferreira, SabrinaRivarola, Viviana AliciaRumie Vittar, Natalia BelenCOMBINATORIAL THERAPIESMELANOMANAPHTOQUINONESNQO1PHOTODYNAMIC THERAPYΒ-LAPACHONEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role in melanogenesis and given its correlation with a poor patient outcome we propose this enzyme as an intriguing target for molecular-based therapeutic regimen against melanoma. Unfortunately, the natural product β-Lapachone (β-Lap), whose antitumor activity is based on NQO1, reported dose-limiting toxicity which hampered its pre-clinical and clinical use. Therefore, new effective and safe therapeutic NQO1-bioactivatable agents for melanoma treatment are desirable. Regarding NQO1, we demonstrated that halogenated β-Lap derivative named PFB is an excellent substrate and effective tumor-selective anticancer compound. In addition, PFB resulted more attractive than the parent β-Lap for treating metastatic-derived melanoma cells. In this context, it would be interesting to design strategies to induce NQO1 activity in cancer cells as a promising combinatorial approach with bioreductive drugs. In this sense, we had reported that photodynamic therapy (PDT) significantly upregulated NQO1 expression. Based on this event, here we demonstrated that the cytotoxic regimen consisting of PFB plus PDT improved synergistic therapeutic combination on melanoma cells. In conclusion, our contribution provides a strong rationale for using therapies that associate photo- and chemotherapy to effectively treat melanoma with modular NQO1 status.Fil: Lamberti, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Morales Vasconsuelo, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Chiaramello, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Ferreira, Vitor Francisco. Universidade Federal Fluminense; BrasilFil: Macedo Oliveira, Milena. Universidade Federal do Rio de Janeiro; BrasilFil: Baptista Ferreira, Sabrina. Universidade Federal do Rio de Janeiro; BrasilFil: Rivarola, Viviana Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Rumie Vittar, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaElsevier France-editions Scientifiques Medicales Elsevier2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/100525Lamberti, María Julia; Morales Vasconsuelo, Ana Belen; Chiaramello, Marianela; Ferreira, Vitor Francisco; Macedo Oliveira, Milena; et al.; NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma; Elsevier France-editions Scientifiques Medicales Elsevier; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie; 108; 12-2018; 1553-15640753-3322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopha.2018.09.159info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0753332218359808info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:01Zoai:ri.conicet.gov.ar:11336/100525instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:01.766CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma |
title |
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma |
spellingShingle |
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma Lamberti, María Julia COMBINATORIAL THERAPIES MELANOMA NAPHTOQUINONES NQO1 PHOTODYNAMIC THERAPY Β-LAPACHONE |
title_short |
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma |
title_full |
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma |
title_fullStr |
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma |
title_full_unstemmed |
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma |
title_sort |
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma |
dc.creator.none.fl_str_mv |
Lamberti, María Julia Morales Vasconsuelo, Ana Belen Chiaramello, Marianela Ferreira, Vitor Francisco Macedo Oliveira, Milena Baptista Ferreira, Sabrina Rivarola, Viviana Alicia Rumie Vittar, Natalia Belen |
author |
Lamberti, María Julia |
author_facet |
Lamberti, María Julia Morales Vasconsuelo, Ana Belen Chiaramello, Marianela Ferreira, Vitor Francisco Macedo Oliveira, Milena Baptista Ferreira, Sabrina Rivarola, Viviana Alicia Rumie Vittar, Natalia Belen |
author_role |
author |
author2 |
Morales Vasconsuelo, Ana Belen Chiaramello, Marianela Ferreira, Vitor Francisco Macedo Oliveira, Milena Baptista Ferreira, Sabrina Rivarola, Viviana Alicia Rumie Vittar, Natalia Belen |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
COMBINATORIAL THERAPIES MELANOMA NAPHTOQUINONES NQO1 PHOTODYNAMIC THERAPY Β-LAPACHONE |
topic |
COMBINATORIAL THERAPIES MELANOMA NAPHTOQUINONES NQO1 PHOTODYNAMIC THERAPY Β-LAPACHONE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role in melanogenesis and given its correlation with a poor patient outcome we propose this enzyme as an intriguing target for molecular-based therapeutic regimen against melanoma. Unfortunately, the natural product β-Lapachone (β-Lap), whose antitumor activity is based on NQO1, reported dose-limiting toxicity which hampered its pre-clinical and clinical use. Therefore, new effective and safe therapeutic NQO1-bioactivatable agents for melanoma treatment are desirable. Regarding NQO1, we demonstrated that halogenated β-Lap derivative named PFB is an excellent substrate and effective tumor-selective anticancer compound. In addition, PFB resulted more attractive than the parent β-Lap for treating metastatic-derived melanoma cells. In this context, it would be interesting to design strategies to induce NQO1 activity in cancer cells as a promising combinatorial approach with bioreductive drugs. In this sense, we had reported that photodynamic therapy (PDT) significantly upregulated NQO1 expression. Based on this event, here we demonstrated that the cytotoxic regimen consisting of PFB plus PDT improved synergistic therapeutic combination on melanoma cells. In conclusion, our contribution provides a strong rationale for using therapies that associate photo- and chemotherapy to effectively treat melanoma with modular NQO1 status. Fil: Lamberti, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina Fil: Morales Vasconsuelo, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina Fil: Chiaramello, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina Fil: Ferreira, Vitor Francisco. Universidade Federal Fluminense; Brasil Fil: Macedo Oliveira, Milena. Universidade Federal do Rio de Janeiro; Brasil Fil: Baptista Ferreira, Sabrina. Universidade Federal do Rio de Janeiro; Brasil Fil: Rivarola, Viviana Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina Fil: Rumie Vittar, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina |
description |
The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role in melanogenesis and given its correlation with a poor patient outcome we propose this enzyme as an intriguing target for molecular-based therapeutic regimen against melanoma. Unfortunately, the natural product β-Lapachone (β-Lap), whose antitumor activity is based on NQO1, reported dose-limiting toxicity which hampered its pre-clinical and clinical use. Therefore, new effective and safe therapeutic NQO1-bioactivatable agents for melanoma treatment are desirable. Regarding NQO1, we demonstrated that halogenated β-Lap derivative named PFB is an excellent substrate and effective tumor-selective anticancer compound. In addition, PFB resulted more attractive than the parent β-Lap for treating metastatic-derived melanoma cells. In this context, it would be interesting to design strategies to induce NQO1 activity in cancer cells as a promising combinatorial approach with bioreductive drugs. In this sense, we had reported that photodynamic therapy (PDT) significantly upregulated NQO1 expression. Based on this event, here we demonstrated that the cytotoxic regimen consisting of PFB plus PDT improved synergistic therapeutic combination on melanoma cells. In conclusion, our contribution provides a strong rationale for using therapies that associate photo- and chemotherapy to effectively treat melanoma with modular NQO1 status. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/100525 Lamberti, María Julia; Morales Vasconsuelo, Ana Belen; Chiaramello, Marianela; Ferreira, Vitor Francisco; Macedo Oliveira, Milena; et al.; NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma; Elsevier France-editions Scientifiques Medicales Elsevier; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie; 108; 12-2018; 1553-1564 0753-3322 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/100525 |
identifier_str_mv |
Lamberti, María Julia; Morales Vasconsuelo, Ana Belen; Chiaramello, Marianela; Ferreira, Vitor Francisco; Macedo Oliveira, Milena; et al.; NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma; Elsevier France-editions Scientifiques Medicales Elsevier; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie; 108; 12-2018; 1553-1564 0753-3322 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopha.2018.09.159 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0753332218359808 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier France-editions Scientifiques Medicales Elsevier |
publisher.none.fl_str_mv |
Elsevier France-editions Scientifiques Medicales Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269779522486272 |
score |
13.13397 |