NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma

Autores
Lamberti, María Julia; Morales Vasconsuelo, Ana Belen; Chiaramello, Marianela; Ferreira, Vitor Francisco; Macedo Oliveira, Milena; Baptista Ferreira, Sabrina; Rivarola, Viviana Alicia; Rumie Vittar, Natalia Belen
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role in melanogenesis and given its correlation with a poor patient outcome we propose this enzyme as an intriguing target for molecular-based therapeutic regimen against melanoma. Unfortunately, the natural product β-Lapachone (β-Lap), whose antitumor activity is based on NQO1, reported dose-limiting toxicity which hampered its pre-clinical and clinical use. Therefore, new effective and safe therapeutic NQO1-bioactivatable agents for melanoma treatment are desirable. Regarding NQO1, we demonstrated that halogenated β-Lap derivative named PFB is an excellent substrate and effective tumor-selective anticancer compound. In addition, PFB resulted more attractive than the parent β-Lap for treating metastatic-derived melanoma cells. In this context, it would be interesting to design strategies to induce NQO1 activity in cancer cells as a promising combinatorial approach with bioreductive drugs. In this sense, we had reported that photodynamic therapy (PDT) significantly upregulated NQO1 expression. Based on this event, here we demonstrated that the cytotoxic regimen consisting of PFB plus PDT improved synergistic therapeutic combination on melanoma cells. In conclusion, our contribution provides a strong rationale for using therapies that associate photo- and chemotherapy to effectively treat melanoma with modular NQO1 status.
Fil: Lamberti, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Morales Vasconsuelo, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Chiaramello, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Ferreira, Vitor Francisco. Universidade Federal Fluminense; Brasil
Fil: Macedo Oliveira, Milena. Universidade Federal do Rio de Janeiro; Brasil
Fil: Baptista Ferreira, Sabrina. Universidade Federal do Rio de Janeiro; Brasil
Fil: Rivarola, Viviana Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Rumie Vittar, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Materia
COMBINATORIAL THERAPIES
MELANOMA
NAPHTOQUINONES
NQO1
PHOTODYNAMIC THERAPY
Β-LAPACHONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/100525
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/100525
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanomaLamberti, María JuliaMorales Vasconsuelo, Ana BelenChiaramello, MarianelaFerreira, Vitor FranciscoMacedo Oliveira, MilenaBaptista Ferreira, SabrinaRivarola, Viviana AliciaRumie Vittar, Natalia BelenCOMBINATORIAL THERAPIESMELANOMANAPHTOQUINONESNQO1PHOTODYNAMIC THERAPYΒ-LAPACHONEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role in melanogenesis and given its correlation with a poor patient outcome we propose this enzyme as an intriguing target for molecular-based therapeutic regimen against melanoma. Unfortunately, the natural product β-Lapachone (β-Lap), whose antitumor activity is based on NQO1, reported dose-limiting toxicity which hampered its pre-clinical and clinical use. Therefore, new effective and safe therapeutic NQO1-bioactivatable agents for melanoma treatment are desirable. Regarding NQO1, we demonstrated that halogenated β-Lap derivative named PFB is an excellent substrate and effective tumor-selective anticancer compound. In addition, PFB resulted more attractive than the parent β-Lap for treating metastatic-derived melanoma cells. In this context, it would be interesting to design strategies to induce NQO1 activity in cancer cells as a promising combinatorial approach with bioreductive drugs. In this sense, we had reported that photodynamic therapy (PDT) significantly upregulated NQO1 expression. Based on this event, here we demonstrated that the cytotoxic regimen consisting of PFB plus PDT improved synergistic therapeutic combination on melanoma cells. In conclusion, our contribution provides a strong rationale for using therapies that associate photo- and chemotherapy to effectively treat melanoma with modular NQO1 status.Fil: Lamberti, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Morales Vasconsuelo, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Chiaramello, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Ferreira, Vitor Francisco. Universidade Federal Fluminense; BrasilFil: Macedo Oliveira, Milena. Universidade Federal do Rio de Janeiro; BrasilFil: Baptista Ferreira, Sabrina. Universidade Federal do Rio de Janeiro; BrasilFil: Rivarola, Viviana Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Rumie Vittar, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaElsevier France-editions Scientifiques Medicales Elsevier2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/100525Lamberti, María Julia; Morales Vasconsuelo, Ana Belen; Chiaramello, Marianela; Ferreira, Vitor Francisco; Macedo Oliveira, Milena; et al.; NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma; Elsevier France-editions Scientifiques Medicales Elsevier; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie; 108; 12-2018; 1553-15640753-3322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopha.2018.09.159info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0753332218359808info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:19:26Zoai:ri.conicet.gov.ar:11336/100525instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:19:26.288CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
title NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
spellingShingle NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
Lamberti, María Julia
COMBINATORIAL THERAPIES
MELANOMA
NAPHTOQUINONES
NQO1
PHOTODYNAMIC THERAPY
Β-LAPACHONE
title_short NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
title_full NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
title_fullStr NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
title_full_unstemmed NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
title_sort NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
dc.creator.none.fl_str_mv Lamberti, María Julia
Morales Vasconsuelo, Ana Belen
Chiaramello, Marianela
Ferreira, Vitor Francisco
Macedo Oliveira, Milena
Baptista Ferreira, Sabrina
Rivarola, Viviana Alicia
Rumie Vittar, Natalia Belen
author Lamberti, María Julia
author_facet Lamberti, María Julia
Morales Vasconsuelo, Ana Belen
Chiaramello, Marianela
Ferreira, Vitor Francisco
Macedo Oliveira, Milena
Baptista Ferreira, Sabrina
Rivarola, Viviana Alicia
Rumie Vittar, Natalia Belen
author_role author
author2 Morales Vasconsuelo, Ana Belen
Chiaramello, Marianela
Ferreira, Vitor Francisco
Macedo Oliveira, Milena
Baptista Ferreira, Sabrina
Rivarola, Viviana Alicia
Rumie Vittar, Natalia Belen
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COMBINATORIAL THERAPIES
MELANOMA
NAPHTOQUINONES
NQO1
PHOTODYNAMIC THERAPY
Β-LAPACHONE
topic COMBINATORIAL THERAPIES
MELANOMA
NAPHTOQUINONES
NQO1
PHOTODYNAMIC THERAPY
Β-LAPACHONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role in melanogenesis and given its correlation with a poor patient outcome we propose this enzyme as an intriguing target for molecular-based therapeutic regimen against melanoma. Unfortunately, the natural product β-Lapachone (β-Lap), whose antitumor activity is based on NQO1, reported dose-limiting toxicity which hampered its pre-clinical and clinical use. Therefore, new effective and safe therapeutic NQO1-bioactivatable agents for melanoma treatment are desirable. Regarding NQO1, we demonstrated that halogenated β-Lap derivative named PFB is an excellent substrate and effective tumor-selective anticancer compound. In addition, PFB resulted more attractive than the parent β-Lap for treating metastatic-derived melanoma cells. In this context, it would be interesting to design strategies to induce NQO1 activity in cancer cells as a promising combinatorial approach with bioreductive drugs. In this sense, we had reported that photodynamic therapy (PDT) significantly upregulated NQO1 expression. Based on this event, here we demonstrated that the cytotoxic regimen consisting of PFB plus PDT improved synergistic therapeutic combination on melanoma cells. In conclusion, our contribution provides a strong rationale for using therapies that associate photo- and chemotherapy to effectively treat melanoma with modular NQO1 status.
Fil: Lamberti, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Morales Vasconsuelo, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Chiaramello, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Ferreira, Vitor Francisco. Universidade Federal Fluminense; Brasil
Fil: Macedo Oliveira, Milena. Universidade Federal do Rio de Janeiro; Brasil
Fil: Baptista Ferreira, Sabrina. Universidade Federal do Rio de Janeiro; Brasil
Fil: Rivarola, Viviana Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Rumie Vittar, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
description The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role in melanogenesis and given its correlation with a poor patient outcome we propose this enzyme as an intriguing target for molecular-based therapeutic regimen against melanoma. Unfortunately, the natural product β-Lapachone (β-Lap), whose antitumor activity is based on NQO1, reported dose-limiting toxicity which hampered its pre-clinical and clinical use. Therefore, new effective and safe therapeutic NQO1-bioactivatable agents for melanoma treatment are desirable. Regarding NQO1, we demonstrated that halogenated β-Lap derivative named PFB is an excellent substrate and effective tumor-selective anticancer compound. In addition, PFB resulted more attractive than the parent β-Lap for treating metastatic-derived melanoma cells. In this context, it would be interesting to design strategies to induce NQO1 activity in cancer cells as a promising combinatorial approach with bioreductive drugs. In this sense, we had reported that photodynamic therapy (PDT) significantly upregulated NQO1 expression. Based on this event, here we demonstrated that the cytotoxic regimen consisting of PFB plus PDT improved synergistic therapeutic combination on melanoma cells. In conclusion, our contribution provides a strong rationale for using therapies that associate photo- and chemotherapy to effectively treat melanoma with modular NQO1 status.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/100525
Lamberti, María Julia; Morales Vasconsuelo, Ana Belen; Chiaramello, Marianela; Ferreira, Vitor Francisco; Macedo Oliveira, Milena; et al.; NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma; Elsevier France-editions Scientifiques Medicales Elsevier; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie; 108; 12-2018; 1553-1564
0753-3322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/100525
identifier_str_mv Lamberti, María Julia; Morales Vasconsuelo, Ana Belen; Chiaramello, Marianela; Ferreira, Vitor Francisco; Macedo Oliveira, Milena; et al.; NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma; Elsevier France-editions Scientifiques Medicales Elsevier; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie; 108; 12-2018; 1553-1564
0753-3322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopha.2018.09.159
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0753332218359808
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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