Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease

Autores
dos Santos, Vanessa V.; Rodrigues, Ana Lúcia S.; Lima, Thereza C. De; Rubiales, Susana Elizabeth; Raisman Vozari, Rita; Prediger, Rui D.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ghrelin is a gastric hormone that stimulates growth hormone (GH) secretion and food intake to regulate energy homeostasis and body weight by binding to its receptor, GH secretagogue receptor (GHSR1a), which is most highly expressed in the pituitary and hypothalamus. Nowadays there is considerable evidence showing that the GHSR1a is also expressed in numerous extra-hypothalamic neuronal populations and the physiological role of ghrelin is by far wider than considered before including learning and memory, anxiety, depression and neuroprotection. The present review attempts to provide a comprehensive picture of the role of ghrelin in the central nervous system and to highlight recent findings showing its potential as an innovative therapeutic agent in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease.
Fil: dos Santos, Vanessa V.. Universidade Federal de Santa Catarina; Brasil
Fil: Rodrigues, Ana Lúcia S.. Universidade Federal de Santa Catarina; Brasil
Fil: Lima, Thereza C. De. Universidade Federal de Santa Catarina; Brasil
Fil: Rubiales, Susana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Raisman Vozari, Rita. Universite Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Prediger, Rui D.. Universidade Federal de Santa Catarina; Brasil
Materia
Ghrelin
Neuroprotector
Alzheimer
Parkinson
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25733
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's diseasedos Santos, Vanessa V.Rodrigues, Ana Lúcia S.Lima, Thereza C. DeRubiales, Susana ElizabethRaisman Vozari, RitaPrediger, Rui D.GhrelinNeuroprotectorAlzheimerParkinsonhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Ghrelin is a gastric hormone that stimulates growth hormone (GH) secretion and food intake to regulate energy homeostasis and body weight by binding to its receptor, GH secretagogue receptor (GHSR1a), which is most highly expressed in the pituitary and hypothalamus. Nowadays there is considerable evidence showing that the GHSR1a is also expressed in numerous extra-hypothalamic neuronal populations and the physiological role of ghrelin is by far wider than considered before including learning and memory, anxiety, depression and neuroprotection. The present review attempts to provide a comprehensive picture of the role of ghrelin in the central nervous system and to highlight recent findings showing its potential as an innovative therapeutic agent in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease.Fil: dos Santos, Vanessa V.. Universidade Federal de Santa Catarina; BrasilFil: Rodrigues, Ana Lúcia S.. Universidade Federal de Santa Catarina; BrasilFil: Lima, Thereza C. De. Universidade Federal de Santa Catarina; BrasilFil: Rubiales, Susana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Raisman Vozari, Rita. Universite Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Prediger, Rui D.. Universidade Federal de Santa Catarina; BrasilBentham Science Publishers2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25733dos Santos, Vanessa V.; Rodrigues, Ana Lúcia S. ; Lima, Thereza C. De; Rubiales, Susana Elizabeth; Raisman Vozari, Rita; et al.; Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease; Bentham Science Publishers; Current Pharmaceutical Design; 19; 38; 7-2013; 6773-67901381-6128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/13816128113199990411info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/111530/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-31T15:25:54Zoai:ri.conicet.gov.ar:11336/25733instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-31 15:25:55.291CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease
title Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease
spellingShingle Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease
dos Santos, Vanessa V.
Ghrelin
Neuroprotector
Alzheimer
Parkinson
title_short Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease
title_full Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease
title_fullStr Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease
title_full_unstemmed Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease
title_sort Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease
dc.creator.none.fl_str_mv dos Santos, Vanessa V.
Rodrigues, Ana Lúcia S.
Lima, Thereza C. De
Rubiales, Susana Elizabeth
Raisman Vozari, Rita
Prediger, Rui D.
author dos Santos, Vanessa V.
author_facet dos Santos, Vanessa V.
Rodrigues, Ana Lúcia S.
Lima, Thereza C. De
Rubiales, Susana Elizabeth
Raisman Vozari, Rita
Prediger, Rui D.
author_role author
author2 Rodrigues, Ana Lúcia S.
Lima, Thereza C. De
Rubiales, Susana Elizabeth
Raisman Vozari, Rita
Prediger, Rui D.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ghrelin
Neuroprotector
Alzheimer
Parkinson
topic Ghrelin
Neuroprotector
Alzheimer
Parkinson
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ghrelin is a gastric hormone that stimulates growth hormone (GH) secretion and food intake to regulate energy homeostasis and body weight by binding to its receptor, GH secretagogue receptor (GHSR1a), which is most highly expressed in the pituitary and hypothalamus. Nowadays there is considerable evidence showing that the GHSR1a is also expressed in numerous extra-hypothalamic neuronal populations and the physiological role of ghrelin is by far wider than considered before including learning and memory, anxiety, depression and neuroprotection. The present review attempts to provide a comprehensive picture of the role of ghrelin in the central nervous system and to highlight recent findings showing its potential as an innovative therapeutic agent in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease.
Fil: dos Santos, Vanessa V.. Universidade Federal de Santa Catarina; Brasil
Fil: Rodrigues, Ana Lúcia S.. Universidade Federal de Santa Catarina; Brasil
Fil: Lima, Thereza C. De. Universidade Federal de Santa Catarina; Brasil
Fil: Rubiales, Susana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Raisman Vozari, Rita. Universite Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Prediger, Rui D.. Universidade Federal de Santa Catarina; Brasil
description Ghrelin is a gastric hormone that stimulates growth hormone (GH) secretion and food intake to regulate energy homeostasis and body weight by binding to its receptor, GH secretagogue receptor (GHSR1a), which is most highly expressed in the pituitary and hypothalamus. Nowadays there is considerable evidence showing that the GHSR1a is also expressed in numerous extra-hypothalamic neuronal populations and the physiological role of ghrelin is by far wider than considered before including learning and memory, anxiety, depression and neuroprotection. The present review attempts to provide a comprehensive picture of the role of ghrelin in the central nervous system and to highlight recent findings showing its potential as an innovative therapeutic agent in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25733
dos Santos, Vanessa V.; Rodrigues, Ana Lúcia S. ; Lima, Thereza C. De; Rubiales, Susana Elizabeth; Raisman Vozari, Rita; et al.; Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease; Bentham Science Publishers; Current Pharmaceutical Design; 19; 38; 7-2013; 6773-6790
1381-6128
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25733
identifier_str_mv dos Santos, Vanessa V.; Rodrigues, Ana Lúcia S. ; Lima, Thereza C. De; Rubiales, Susana Elizabeth; Raisman Vozari, Rita; et al.; Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease; Bentham Science Publishers; Current Pharmaceutical Design; 19; 38; 7-2013; 6773-6790
1381-6128
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/13816128113199990411
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/111530/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1861214748300804096
score 12.720982

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