Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis

Autores
Kaylor, Adam; Dwivedi, Prabha; Pittman, Jennifer J.; Monge, Maria Eugenia; Cheng, Guilong; Li, Shelly; Fernández, Facundo M.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A new ion generation method, named plasma-spray ionization (PLASI) for direct analysis of liquid streams, such as in continuous infusion experiments or liquid chromatography (LC), is reported. PLASI addresses many of the analytical limitations of electrospray ionization (ESI) and has potential for real time process stream analysis and reaction monitoring under atmospheric conditions in non-ESI friendly scenarios. In PLASI-mass spectrometry (MS), the liquid stream is pneumatically nebulized and partially charged at low voltages; the resultant aerosol is thus entrained with a gaseous plasma plume from a distal glow discharge prior to MS detection. PLASI-MS not only overcomes ESI-MS limitations but also generates simpler mass spectra with minimal adduct and cluster formation. PLASI utilizes the atomization capabilities of an ESI sprayer operated below the ESI threshold to generate gas-phase aerosols that are then ionized by the plasma stream. When operated at or above the ESI threshold, ionization by traditional ESI mechanisms is achieved. The multimodal nature of the technique enables readily switching between plasma and ESI operation. It is expected that PLASI will enable analyzing a wide range of analytes in complex matrices and less-restricted solvent systems, providing more flexibility than that achievable by ESI alone.
Fil: Kaylor, Adam. Georgia Institute of Techology; Estados Unidos
Fil: Dwivedi, Prabha. Georgia Institute of Techology; Estados Unidos
Fil: Pittman, Jennifer J.. Georgia Institute of Techology; Estados Unidos
Fil: Monge, Maria Eugenia. Georgia Institute of Techology; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina
Fil: Cheng, Guilong. Pfizer Analytical R&D; Estados Unidos
Fil: Li, Shelly. Pfizer Analytical R&D; Estados Unidos
Fil: Fernández, Facundo M.. Georgia Institute of Techology; Estados Unidos
Materia
Dart
Mass Spectrometry
Plasma Ionization
Process And Reaction Monitoring
Liquid-Phase Separations
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30164
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream AnalysisKaylor, AdamDwivedi, PrabhaPittman, Jennifer J.Monge, Maria EugeniaCheng, GuilongLi, ShellyFernández, Facundo M.DartMass SpectrometryPlasma IonizationProcess And Reaction MonitoringLiquid-Phase Separationshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A new ion generation method, named plasma-spray ionization (PLASI) for direct analysis of liquid streams, such as in continuous infusion experiments or liquid chromatography (LC), is reported. PLASI addresses many of the analytical limitations of electrospray ionization (ESI) and has potential for real time process stream analysis and reaction monitoring under atmospheric conditions in non-ESI friendly scenarios. In PLASI-mass spectrometry (MS), the liquid stream is pneumatically nebulized and partially charged at low voltages; the resultant aerosol is thus entrained with a gaseous plasma plume from a distal glow discharge prior to MS detection. PLASI-MS not only overcomes ESI-MS limitations but also generates simpler mass spectra with minimal adduct and cluster formation. PLASI utilizes the atomization capabilities of an ESI sprayer operated below the ESI threshold to generate gas-phase aerosols that are then ionized by the plasma stream. When operated at or above the ESI threshold, ionization by traditional ESI mechanisms is achieved. The multimodal nature of the technique enables readily switching between plasma and ESI operation. It is expected that PLASI will enable analyzing a wide range of analytes in complex matrices and less-restricted solvent systems, providing more flexibility than that achievable by ESI alone.Fil: Kaylor, Adam. Georgia Institute of Techology; Estados UnidosFil: Dwivedi, Prabha. Georgia Institute of Techology; Estados UnidosFil: Pittman, Jennifer J.. Georgia Institute of Techology; Estados UnidosFil: Monge, Maria Eugenia. Georgia Institute of Techology; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Cheng, Guilong. Pfizer Analytical R&D; Estados UnidosFil: Li, Shelly. Pfizer Analytical R&D; Estados UnidosFil: Fernández, Facundo M.. Georgia Institute of Techology; Estados UnidosSpringer2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30164Kaylor, Adam; Dwivedi, Prabha ; Pittman, Jennifer J. ; Monge, Maria Eugenia; Cheng, Guilong ; et al.; Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis; Springer; Journal of The American Society for Mass Spectrometry; 25; 10; 7-2014; 1788-17931044-03051879-1123CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s13361-014-0948-2info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs13361-014-0948-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:35Zoai:ri.conicet.gov.ar:11336/30164instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:35.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis
title Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis
spellingShingle Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis
Kaylor, Adam
Dart
Mass Spectrometry
Plasma Ionization
Process And Reaction Monitoring
Liquid-Phase Separations
title_short Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis
title_full Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis
title_fullStr Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis
title_full_unstemmed Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis
title_sort Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis
dc.creator.none.fl_str_mv Kaylor, Adam
Dwivedi, Prabha
Pittman, Jennifer J.
Monge, Maria Eugenia
Cheng, Guilong
Li, Shelly
Fernández, Facundo M.
author Kaylor, Adam
author_facet Kaylor, Adam
Dwivedi, Prabha
Pittman, Jennifer J.
Monge, Maria Eugenia
Cheng, Guilong
Li, Shelly
Fernández, Facundo M.
author_role author
author2 Dwivedi, Prabha
Pittman, Jennifer J.
Monge, Maria Eugenia
Cheng, Guilong
Li, Shelly
Fernández, Facundo M.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Dart
Mass Spectrometry
Plasma Ionization
Process And Reaction Monitoring
Liquid-Phase Separations
topic Dart
Mass Spectrometry
Plasma Ionization
Process And Reaction Monitoring
Liquid-Phase Separations
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A new ion generation method, named plasma-spray ionization (PLASI) for direct analysis of liquid streams, such as in continuous infusion experiments or liquid chromatography (LC), is reported. PLASI addresses many of the analytical limitations of electrospray ionization (ESI) and has potential for real time process stream analysis and reaction monitoring under atmospheric conditions in non-ESI friendly scenarios. In PLASI-mass spectrometry (MS), the liquid stream is pneumatically nebulized and partially charged at low voltages; the resultant aerosol is thus entrained with a gaseous plasma plume from a distal glow discharge prior to MS detection. PLASI-MS not only overcomes ESI-MS limitations but also generates simpler mass spectra with minimal adduct and cluster formation. PLASI utilizes the atomization capabilities of an ESI sprayer operated below the ESI threshold to generate gas-phase aerosols that are then ionized by the plasma stream. When operated at or above the ESI threshold, ionization by traditional ESI mechanisms is achieved. The multimodal nature of the technique enables readily switching between plasma and ESI operation. It is expected that PLASI will enable analyzing a wide range of analytes in complex matrices and less-restricted solvent systems, providing more flexibility than that achievable by ESI alone.
Fil: Kaylor, Adam. Georgia Institute of Techology; Estados Unidos
Fil: Dwivedi, Prabha. Georgia Institute of Techology; Estados Unidos
Fil: Pittman, Jennifer J.. Georgia Institute of Techology; Estados Unidos
Fil: Monge, Maria Eugenia. Georgia Institute of Techology; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina
Fil: Cheng, Guilong. Pfizer Analytical R&D; Estados Unidos
Fil: Li, Shelly. Pfizer Analytical R&D; Estados Unidos
Fil: Fernández, Facundo M.. Georgia Institute of Techology; Estados Unidos
description A new ion generation method, named plasma-spray ionization (PLASI) for direct analysis of liquid streams, such as in continuous infusion experiments or liquid chromatography (LC), is reported. PLASI addresses many of the analytical limitations of electrospray ionization (ESI) and has potential for real time process stream analysis and reaction monitoring under atmospheric conditions in non-ESI friendly scenarios. In PLASI-mass spectrometry (MS), the liquid stream is pneumatically nebulized and partially charged at low voltages; the resultant aerosol is thus entrained with a gaseous plasma plume from a distal glow discharge prior to MS detection. PLASI-MS not only overcomes ESI-MS limitations but also generates simpler mass spectra with minimal adduct and cluster formation. PLASI utilizes the atomization capabilities of an ESI sprayer operated below the ESI threshold to generate gas-phase aerosols that are then ionized by the plasma stream. When operated at or above the ESI threshold, ionization by traditional ESI mechanisms is achieved. The multimodal nature of the technique enables readily switching between plasma and ESI operation. It is expected that PLASI will enable analyzing a wide range of analytes in complex matrices and less-restricted solvent systems, providing more flexibility than that achievable by ESI alone.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30164
Kaylor, Adam; Dwivedi, Prabha ; Pittman, Jennifer J. ; Monge, Maria Eugenia; Cheng, Guilong ; et al.; Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis; Springer; Journal of The American Society for Mass Spectrometry; 25; 10; 7-2014; 1788-1793
1044-0305
1879-1123
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30164
identifier_str_mv Kaylor, Adam; Dwivedi, Prabha ; Pittman, Jennifer J. ; Monge, Maria Eugenia; Cheng, Guilong ; et al.; Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis; Springer; Journal of The American Society for Mass Spectrometry; 25; 10; 7-2014; 1788-1793
1044-0305
1879-1123
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s13361-014-0948-2
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs13361-014-0948-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613371827060736
score 13.070432

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