Banking on iPSC--is it doable and is it worthwhile
- Autores
- Solomon, Susan; Pitossi, Fernando Juan; Rao, Mahendra S
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The discovery of induced pluripotent stem cells (iPSCs) and concurrent development of protocols for their cell-type specific differentiation have revolutionized studies of diseases and raised the possibility that personalized medicine may be achievable. Realizing the full potential of iPSC will require addressing the challenges inherent in obtaining appropriate cells for millions of individuals while meeting the regulatory requirements of delivering therapy and keeping costs affordable. Critical to making PSC based cell therapy widely accessible is determining which mode of cell collection, storage and distribution, will work. In this manuscript we suggest that moderate sized bank where a diverse set of lines carrying different combinations of commonly present HLA alleles are banked and differentiated cells are made available to matched recipients as need dictates may be a solution. We discuss the issues related to developing such a bank and how it could be constructed and propose a bank of selected HLA phenotypes from carefully screened healthy individuals as a solution to delivering personalized medicine.
Fil: Solomon, Susan. New York Stem Cell Foundation; Estados Unidos
Fil: Pitossi, Fernando Juan. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Rao, Mahendra S. National Institutes Of Health. National Cancer Institute; Estados Unidos - Materia
-
Ips
Reprogramación
Banco - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/10492
Ver los metadatos del registro completo
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Banking on iPSC--is it doable and is it worthwhileSolomon, SusanPitossi, Fernando JuanRao, Mahendra SIpsReprogramaciónBancohttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The discovery of induced pluripotent stem cells (iPSCs) and concurrent development of protocols for their cell-type specific differentiation have revolutionized studies of diseases and raised the possibility that personalized medicine may be achievable. Realizing the full potential of iPSC will require addressing the challenges inherent in obtaining appropriate cells for millions of individuals while meeting the regulatory requirements of delivering therapy and keeping costs affordable. Critical to making PSC based cell therapy widely accessible is determining which mode of cell collection, storage and distribution, will work. In this manuscript we suggest that moderate sized bank where a diverse set of lines carrying different combinations of commonly present HLA alleles are banked and differentiated cells are made available to matched recipients as need dictates may be a solution. We discuss the issues related to developing such a bank and how it could be constructed and propose a bank of selected HLA phenotypes from carefully screened healthy individuals as a solution to delivering personalized medicine.Fil: Solomon, Susan. New York Stem Cell Foundation; Estados UnidosFil: Pitossi, Fernando Juan. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Rao, Mahendra S. National Institutes Of Health. National Cancer Institute; Estados UnidosHumana Press2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10492Solomon, Susan; Pitossi, Fernando Juan; Rao, Mahendra S; Banking on iPSC--is it doable and is it worthwhile; Humana Press; Stem Cell Reviews And Reports; 11; 1; 2-2015; 1-101550-8943enginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs12015-014-9574-4info:eu-repo/semantics/altIdentifier/doi/10.1007/s12015-014-9574-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:39Zoai:ri.conicet.gov.ar:11336/10492instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:39.436CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Banking on iPSC--is it doable and is it worthwhile |
title |
Banking on iPSC--is it doable and is it worthwhile |
spellingShingle |
Banking on iPSC--is it doable and is it worthwhile Solomon, Susan Ips Reprogramación Banco |
title_short |
Banking on iPSC--is it doable and is it worthwhile |
title_full |
Banking on iPSC--is it doable and is it worthwhile |
title_fullStr |
Banking on iPSC--is it doable and is it worthwhile |
title_full_unstemmed |
Banking on iPSC--is it doable and is it worthwhile |
title_sort |
Banking on iPSC--is it doable and is it worthwhile |
dc.creator.none.fl_str_mv |
Solomon, Susan Pitossi, Fernando Juan Rao, Mahendra S |
author |
Solomon, Susan |
author_facet |
Solomon, Susan Pitossi, Fernando Juan Rao, Mahendra S |
author_role |
author |
author2 |
Pitossi, Fernando Juan Rao, Mahendra S |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Ips Reprogramación Banco |
topic |
Ips Reprogramación Banco |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The discovery of induced pluripotent stem cells (iPSCs) and concurrent development of protocols for their cell-type specific differentiation have revolutionized studies of diseases and raised the possibility that personalized medicine may be achievable. Realizing the full potential of iPSC will require addressing the challenges inherent in obtaining appropriate cells for millions of individuals while meeting the regulatory requirements of delivering therapy and keeping costs affordable. Critical to making PSC based cell therapy widely accessible is determining which mode of cell collection, storage and distribution, will work. In this manuscript we suggest that moderate sized bank where a diverse set of lines carrying different combinations of commonly present HLA alleles are banked and differentiated cells are made available to matched recipients as need dictates may be a solution. We discuss the issues related to developing such a bank and how it could be constructed and propose a bank of selected HLA phenotypes from carefully screened healthy individuals as a solution to delivering personalized medicine. Fil: Solomon, Susan. New York Stem Cell Foundation; Estados Unidos Fil: Pitossi, Fernando Juan. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina Fil: Rao, Mahendra S. National Institutes Of Health. National Cancer Institute; Estados Unidos |
description |
The discovery of induced pluripotent stem cells (iPSCs) and concurrent development of protocols for their cell-type specific differentiation have revolutionized studies of diseases and raised the possibility that personalized medicine may be achievable. Realizing the full potential of iPSC will require addressing the challenges inherent in obtaining appropriate cells for millions of individuals while meeting the regulatory requirements of delivering therapy and keeping costs affordable. Critical to making PSC based cell therapy widely accessible is determining which mode of cell collection, storage and distribution, will work. In this manuscript we suggest that moderate sized bank where a diverse set of lines carrying different combinations of commonly present HLA alleles are banked and differentiated cells are made available to matched recipients as need dictates may be a solution. We discuss the issues related to developing such a bank and how it could be constructed and propose a bank of selected HLA phenotypes from carefully screened healthy individuals as a solution to delivering personalized medicine. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/10492 Solomon, Susan; Pitossi, Fernando Juan; Rao, Mahendra S; Banking on iPSC--is it doable and is it worthwhile; Humana Press; Stem Cell Reviews And Reports; 11; 1; 2-2015; 1-10 1550-8943 |
url |
http://hdl.handle.net/11336/10492 |
identifier_str_mv |
Solomon, Susan; Pitossi, Fernando Juan; Rao, Mahendra S; Banking on iPSC--is it doable and is it worthwhile; Humana Press; Stem Cell Reviews And Reports; 11; 1; 2-2015; 1-10 1550-8943 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs12015-014-9574-4 info:eu-repo/semantics/altIdentifier/doi/10.1007/s12015-014-9574-4 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Humana Press |
publisher.none.fl_str_mv |
Humana Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613746501091328 |
score |
13.070432 |