Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates

Autores
Enderle, Ana Gabriela; Bosso, Matteo; Groß, Rüdiger; Heiland, Magdalena; Bollini, Mariela; Culzoni, Maria Julia; Kirchhoff, Frank; Münch, Jan; Streb, Carsten
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polyoxometalates (POMs), molecular metal oxide anions, are inorganic clusters with promising antiviral activity. Herein we report increased anti-HIV-1 activity of a POM when electrostatically combined with organic counter-cations. To this end, Keggin-type cerium tungstate POMs have been combined with organic methyl-caffeinium (Caf) cations, and their cytotoxicity, antiviral activity and mode of action have been studied. The novel compound, Caf4K[β2-CeSiW11O39]×H2O, exhibits sub-nanomolar antiviral activity and inhibits HIV-1 infectivity by acting on an early step of the viral infection cycle. This work demonstrates that combination of POM anions and organic bioactive cations can be a powerful new strategy to increase antiviral activity of these inorganic compounds.
Fil: Enderle, Ana Gabriela. Universitat Ulm; Alemania. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina
Fil: Bosso, Matteo. Universitat Ulm; Alemania
Fil: Groß, Rüdiger. Universitat Ulm; Alemania
Fil: Heiland, Magdalena. Universitat Ulm; Alemania
Fil: Bollini, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina
Fil: Culzoni, Maria Julia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Kirchhoff, Frank. Universitat Ulm; Alemania
Fil: Münch, Jan. Universitat Ulm; Alemania
Fil: Streb, Carsten. Universitat Ulm; Alemania
Materia
ANTIVIRAL ACTIVITY
CATIONS
HIV
POLYOXOMETALATES
SELF-ASSEMBLY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/165116
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/165116
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized PolyoxometalatesEnderle, Ana GabrielaBosso, MatteoGroß, RüdigerHeiland, MagdalenaBollini, MarielaCulzoni, Maria JuliaKirchhoff, FrankMünch, JanStreb, CarstenANTIVIRAL ACTIVITYCATIONSHIVPOLYOXOMETALATESSELF-ASSEMBLYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Polyoxometalates (POMs), molecular metal oxide anions, are inorganic clusters with promising antiviral activity. Herein we report increased anti-HIV-1 activity of a POM when electrostatically combined with organic counter-cations. To this end, Keggin-type cerium tungstate POMs have been combined with organic methyl-caffeinium (Caf) cations, and their cytotoxicity, antiviral activity and mode of action have been studied. The novel compound, Caf4K[β2-CeSiW11O39]×H2O, exhibits sub-nanomolar antiviral activity and inhibits HIV-1 infectivity by acting on an early step of the viral infection cycle. This work demonstrates that combination of POM anions and organic bioactive cations can be a powerful new strategy to increase antiviral activity of these inorganic compounds.Fil: Enderle, Ana Gabriela. Universitat Ulm; Alemania. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Bosso, Matteo. Universitat Ulm; AlemaniaFil: Groß, Rüdiger. Universitat Ulm; AlemaniaFil: Heiland, Magdalena. Universitat Ulm; AlemaniaFil: Bollini, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Culzoni, Maria Julia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Kirchhoff, Frank. Universitat Ulm; AlemaniaFil: Münch, Jan. Universitat Ulm; AlemaniaFil: Streb, Carsten. Universitat Ulm; AlemaniaWiley VCH Verlag2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/165116Enderle, Ana Gabriela; Bosso, Matteo; Groß, Rüdiger; Heiland, Magdalena; Bollini, Mariela; et al.; Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates; Wiley VCH Verlag; Chemmedchem; 16; 17; 5-2021; 2727-27301860-7179CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cmdc.202100281info:eu-repo/semantics/altIdentifier/doi/10.1002/cmdc.202100281info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:47Zoai:ri.conicet.gov.ar:11336/165116instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:47.611CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates
title Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates
spellingShingle Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates
Enderle, Ana Gabriela
ANTIVIRAL ACTIVITY
CATIONS
HIV
POLYOXOMETALATES
SELF-ASSEMBLY
title_short Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates
title_full Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates
title_fullStr Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates
title_full_unstemmed Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates
title_sort Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates
dc.creator.none.fl_str_mv Enderle, Ana Gabriela
Bosso, Matteo
Groß, Rüdiger
Heiland, Magdalena
Bollini, Mariela
Culzoni, Maria Julia
Kirchhoff, Frank
Münch, Jan
Streb, Carsten
author Enderle, Ana Gabriela
author_facet Enderle, Ana Gabriela
Bosso, Matteo
Groß, Rüdiger
Heiland, Magdalena
Bollini, Mariela
Culzoni, Maria Julia
Kirchhoff, Frank
Münch, Jan
Streb, Carsten
author_role author
author2 Bosso, Matteo
Groß, Rüdiger
Heiland, Magdalena
Bollini, Mariela
Culzoni, Maria Julia
Kirchhoff, Frank
Münch, Jan
Streb, Carsten
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIVIRAL ACTIVITY
CATIONS
HIV
POLYOXOMETALATES
SELF-ASSEMBLY
topic ANTIVIRAL ACTIVITY
CATIONS
HIV
POLYOXOMETALATES
SELF-ASSEMBLY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Polyoxometalates (POMs), molecular metal oxide anions, are inorganic clusters with promising antiviral activity. Herein we report increased anti-HIV-1 activity of a POM when electrostatically combined with organic counter-cations. To this end, Keggin-type cerium tungstate POMs have been combined with organic methyl-caffeinium (Caf) cations, and their cytotoxicity, antiviral activity and mode of action have been studied. The novel compound, Caf4K[β2-CeSiW11O39]×H2O, exhibits sub-nanomolar antiviral activity and inhibits HIV-1 infectivity by acting on an early step of the viral infection cycle. This work demonstrates that combination of POM anions and organic bioactive cations can be a powerful new strategy to increase antiviral activity of these inorganic compounds.
Fil: Enderle, Ana Gabriela. Universitat Ulm; Alemania. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina
Fil: Bosso, Matteo. Universitat Ulm; Alemania
Fil: Groß, Rüdiger. Universitat Ulm; Alemania
Fil: Heiland, Magdalena. Universitat Ulm; Alemania
Fil: Bollini, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina
Fil: Culzoni, Maria Julia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Kirchhoff, Frank. Universitat Ulm; Alemania
Fil: Münch, Jan. Universitat Ulm; Alemania
Fil: Streb, Carsten. Universitat Ulm; Alemania
description Polyoxometalates (POMs), molecular metal oxide anions, are inorganic clusters with promising antiviral activity. Herein we report increased anti-HIV-1 activity of a POM when electrostatically combined with organic counter-cations. To this end, Keggin-type cerium tungstate POMs have been combined with organic methyl-caffeinium (Caf) cations, and their cytotoxicity, antiviral activity and mode of action have been studied. The novel compound, Caf4K[β2-CeSiW11O39]×H2O, exhibits sub-nanomolar antiviral activity and inhibits HIV-1 infectivity by acting on an early step of the viral infection cycle. This work demonstrates that combination of POM anions and organic bioactive cations can be a powerful new strategy to increase antiviral activity of these inorganic compounds.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/165116
Enderle, Ana Gabriela; Bosso, Matteo; Groß, Rüdiger; Heiland, Magdalena; Bollini, Mariela; et al.; Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates; Wiley VCH Verlag; Chemmedchem; 16; 17; 5-2021; 2727-2730
1860-7179
CONICET Digital
CONICET
url http://hdl.handle.net/11336/165116
identifier_str_mv Enderle, Ana Gabriela; Bosso, Matteo; Groß, Rüdiger; Heiland, Magdalena; Bollini, Mariela; et al.; Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates; Wiley VCH Verlag; Chemmedchem; 16; 17; 5-2021; 2727-2730
1860-7179
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cmdc.202100281
info:eu-repo/semantics/altIdentifier/doi/10.1002/cmdc.202100281
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614019368878080
score 13.070432

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