Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization

Autores
León Félix, L.; Sanz, B.; Sebastián, V.; Torres Molina, Teobaldo Enrique; Sousa, Marcelo Henrique; Coaquira, J. A. H.; Ibarra, M.R.; Goya, Gerardo Fabian
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The integration of noble metal and magnetic nanoparticles with controlled structures that can couple various specific effects to the different nanocomposite in multifunctional nanosystems have been found interesting in the field of medicine. In this work, we show synthesis route to prepare small Au nanoparticles of sizes = 3.9 ± 0.2 nm attached to Fe 3 O 4 nanoparticle cores ( = 49.2 ± 3.5 nm) in aqueous medium for potential application as a nano-heater. Remarkably, the resulted Au decorated PEI-Fe 3 O 4 (Au@PEI-Fe 3 O 4 ) nanoparticles are able to retain bulk magnetic moment M S = 82–84 Am 2 /kg Fe3O4 , with the Verwey transition observed at T V = 98 K. In addition, the in vitro cytotoxicity analysis of the nanosystem microglial BV2 cells showed high viability (>97.5%) to concentrate up to 100 µg/mL in comparison to the control samples. In vitro heating experiments on microglial BV2 cells under an ac magnetic field (H 0 = 23.87 kA/m; f = 571 kHz) yielded specific power absorption (SPA) values of SPA = 43 ± 3 and 49 ± 1 μW/cell for PEI-Fe 3 O 4 and Au@PEI-Fe 3 O 4 NPs, respectively. These similar intracellular SPA values imply that functionalization of the magnetic particles with Au did not change the heating efficiency, providing at the same time a more flexible platform for multifunctional functionalization.
Fil: León Félix, L.. Universidade do Brasília; Brasil. Universidad de Zaragoza; España
Fil: Sanz, B.. Nb Nanoscale Biomagnetics S.l.; España
Fil: Sebastián, V.. Universidad de Zaragoza; España. Centro de Investigación en Red en Bioingeniería; España
Fil: Torres Molina, Teobaldo Enrique. Universidad de Zaragoza; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Sousa, Marcelo Henrique. Universidade do Brasília; Brasil
Fil: Coaquira, J. A. H.. Universidade do Brasília; Brasil
Fil: Ibarra, M.R.. Universidad de Zaragoza; España
Fil: Goya, Gerardo Fabian. Universidad de Zaragoza; España
Materia
GOLD NANOPARTICLES
NANOMAGNETISM
HYPERTHERMIA
SURFACE FUNCTIONALIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125157
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/125157
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalizationLeón Félix, L.Sanz, B.Sebastián, V.Torres Molina, Teobaldo EnriqueSousa, Marcelo HenriqueCoaquira, J. A. H.Ibarra, M.R.Goya, Gerardo FabianGOLD NANOPARTICLESNANOMAGNETISMHYPERTHERMIASURFACE FUNCTIONALIZATIONhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The integration of noble metal and magnetic nanoparticles with controlled structures that can couple various specific effects to the different nanocomposite in multifunctional nanosystems have been found interesting in the field of medicine. In this work, we show synthesis route to prepare small Au nanoparticles of sizes = 3.9 ± 0.2 nm attached to Fe 3 O 4 nanoparticle cores ( = 49.2 ± 3.5 nm) in aqueous medium for potential application as a nano-heater. Remarkably, the resulted Au decorated PEI-Fe 3 O 4 (Au@PEI-Fe 3 O 4 ) nanoparticles are able to retain bulk magnetic moment M S = 82–84 Am 2 /kg Fe3O4 , with the Verwey transition observed at T V = 98 K. In addition, the in vitro cytotoxicity analysis of the nanosystem microglial BV2 cells showed high viability (>97.5%) to concentrate up to 100 µg/mL in comparison to the control samples. In vitro heating experiments on microglial BV2 cells under an ac magnetic field (H 0 = 23.87 kA/m; f = 571 kHz) yielded specific power absorption (SPA) values of SPA = 43 ± 3 and 49 ± 1 μW/cell for PEI-Fe 3 O 4 and Au@PEI-Fe 3 O 4 NPs, respectively. These similar intracellular SPA values imply that functionalization of the magnetic particles with Au did not change the heating efficiency, providing at the same time a more flexible platform for multifunctional functionalization.Fil: León Félix, L.. Universidade do Brasília; Brasil. Universidad de Zaragoza; EspañaFil: Sanz, B.. Nb Nanoscale Biomagnetics S.l.; EspañaFil: Sebastián, V.. Universidad de Zaragoza; España. Centro de Investigación en Red en Bioingeniería; EspañaFil: Torres Molina, Teobaldo Enrique. Universidad de Zaragoza; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Sousa, Marcelo Henrique. Universidade do Brasília; BrasilFil: Coaquira, J. A. H.. Universidade do Brasília; BrasilFil: Ibarra, M.R.. Universidad de Zaragoza; EspañaFil: Goya, Gerardo Fabian. Universidad de Zaragoza; EspañaNature Publishing Group2019-03-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125157León Félix, L.; Sanz, B.; Sebastián, V.; Torres Molina, Teobaldo Enrique; Sousa, Marcelo Henrique; et al.; Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization; Nature Publishing Group; Scientific Reports; 9; 1; 12-3-2019; 1-112045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-019-40769-2info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-019-40769-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:17Zoai:ri.conicet.gov.ar:11336/125157instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:17.961CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization
title Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization
spellingShingle Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization
León Félix, L.
GOLD NANOPARTICLES
NANOMAGNETISM
HYPERTHERMIA
SURFACE FUNCTIONALIZATION
title_short Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization
title_full Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization
title_fullStr Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization
title_full_unstemmed Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization
title_sort Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization
dc.creator.none.fl_str_mv León Félix, L.
Sanz, B.
Sebastián, V.
Torres Molina, Teobaldo Enrique
Sousa, Marcelo Henrique
Coaquira, J. A. H.
Ibarra, M.R.
Goya, Gerardo Fabian
author León Félix, L.
author_facet León Félix, L.
Sanz, B.
Sebastián, V.
Torres Molina, Teobaldo Enrique
Sousa, Marcelo Henrique
Coaquira, J. A. H.
Ibarra, M.R.
Goya, Gerardo Fabian
author_role author
author2 Sanz, B.
Sebastián, V.
Torres Molina, Teobaldo Enrique
Sousa, Marcelo Henrique
Coaquira, J. A. H.
Ibarra, M.R.
Goya, Gerardo Fabian
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GOLD NANOPARTICLES
NANOMAGNETISM
HYPERTHERMIA
SURFACE FUNCTIONALIZATION
topic GOLD NANOPARTICLES
NANOMAGNETISM
HYPERTHERMIA
SURFACE FUNCTIONALIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The integration of noble metal and magnetic nanoparticles with controlled structures that can couple various specific effects to the different nanocomposite in multifunctional nanosystems have been found interesting in the field of medicine. In this work, we show synthesis route to prepare small Au nanoparticles of sizes = 3.9 ± 0.2 nm attached to Fe 3 O 4 nanoparticle cores ( = 49.2 ± 3.5 nm) in aqueous medium for potential application as a nano-heater. Remarkably, the resulted Au decorated PEI-Fe 3 O 4 (Au@PEI-Fe 3 O 4 ) nanoparticles are able to retain bulk magnetic moment M S = 82–84 Am 2 /kg Fe3O4 , with the Verwey transition observed at T V = 98 K. In addition, the in vitro cytotoxicity analysis of the nanosystem microglial BV2 cells showed high viability (>97.5%) to concentrate up to 100 µg/mL in comparison to the control samples. In vitro heating experiments on microglial BV2 cells under an ac magnetic field (H 0 = 23.87 kA/m; f = 571 kHz) yielded specific power absorption (SPA) values of SPA = 43 ± 3 and 49 ± 1 μW/cell for PEI-Fe 3 O 4 and Au@PEI-Fe 3 O 4 NPs, respectively. These similar intracellular SPA values imply that functionalization of the magnetic particles with Au did not change the heating efficiency, providing at the same time a more flexible platform for multifunctional functionalization.
Fil: León Félix, L.. Universidade do Brasília; Brasil. Universidad de Zaragoza; España
Fil: Sanz, B.. Nb Nanoscale Biomagnetics S.l.; España
Fil: Sebastián, V.. Universidad de Zaragoza; España. Centro de Investigación en Red en Bioingeniería; España
Fil: Torres Molina, Teobaldo Enrique. Universidad de Zaragoza; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Sousa, Marcelo Henrique. Universidade do Brasília; Brasil
Fil: Coaquira, J. A. H.. Universidade do Brasília; Brasil
Fil: Ibarra, M.R.. Universidad de Zaragoza; España
Fil: Goya, Gerardo Fabian. Universidad de Zaragoza; España
description The integration of noble metal and magnetic nanoparticles with controlled structures that can couple various specific effects to the different nanocomposite in multifunctional nanosystems have been found interesting in the field of medicine. In this work, we show synthesis route to prepare small Au nanoparticles of sizes = 3.9 ± 0.2 nm attached to Fe 3 O 4 nanoparticle cores ( = 49.2 ± 3.5 nm) in aqueous medium for potential application as a nano-heater. Remarkably, the resulted Au decorated PEI-Fe 3 O 4 (Au@PEI-Fe 3 O 4 ) nanoparticles are able to retain bulk magnetic moment M S = 82–84 Am 2 /kg Fe3O4 , with the Verwey transition observed at T V = 98 K. In addition, the in vitro cytotoxicity analysis of the nanosystem microglial BV2 cells showed high viability (>97.5%) to concentrate up to 100 µg/mL in comparison to the control samples. In vitro heating experiments on microglial BV2 cells under an ac magnetic field (H 0 = 23.87 kA/m; f = 571 kHz) yielded specific power absorption (SPA) values of SPA = 43 ± 3 and 49 ± 1 μW/cell for PEI-Fe 3 O 4 and Au@PEI-Fe 3 O 4 NPs, respectively. These similar intracellular SPA values imply that functionalization of the magnetic particles with Au did not change the heating efficiency, providing at the same time a more flexible platform for multifunctional functionalization.
publishDate 2019
dc.date.none.fl_str_mv 2019-03-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125157
León Félix, L.; Sanz, B.; Sebastián, V.; Torres Molina, Teobaldo Enrique; Sousa, Marcelo Henrique; et al.; Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization; Nature Publishing Group; Scientific Reports; 9; 1; 12-3-2019; 1-11
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125157
identifier_str_mv León Félix, L.; Sanz, B.; Sebastián, V.; Torres Molina, Teobaldo Enrique; Sousa, Marcelo Henrique; et al.; Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surface-functionalization; Nature Publishing Group; Scientific Reports; 9; 1; 12-3-2019; 1-11
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-019-40769-2
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-019-40769-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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