Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats

Autores
Altamirano, Gabriela Anahí; Delconte, Melisa; Gomez, Ayelen Luciana; Ingaramo, Paola Inés; Bosquiazzo, Veronica Lis; Luque, Enrique Hugo; Muñoz de Toro, Monica Milagros; Kass, Laura
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated. At PND21, GBH-exposed male rats exhibited greater development of the mammary gland with increased stromal collagen organization and terminal end buds (TEBs) compared to control rats. At PND60, the number of TEBs remained high and was accompanied by an increase in mast cell infiltration, proliferation and ESR1 expression in GBH-exposed male rats. In contrast, no effects were observed in E2 and T serum levels and AR expression in both days studied. Our results showed that a postnatal subacute treatment with GBH induces endocrine-disrupting effects in the male mammary gland in vivo, altering its normal development.
Fil: Altamirano, Gabriela Anahí. Universidad Nacional del Litoral; Argentina
Fil: Delconte, Melisa. Universidad Nacional del Litoral; Argentina
Fil: Gomez, Ayelen Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Ingaramo, Paola Inés. Universidad Nacional del Litoral; Argentina
Fil: Bosquiazzo, Veronica Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Luque, Enrique Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; Argentina
Fil: Kass, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Materia
ESTROGEN RECEPTOR
GLYPHOSATE-BASED HERBICIDE
MALE RATS
MAMMARY GLAND
MAST CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86491
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/86491
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male ratsAltamirano, Gabriela AnahíDelconte, MelisaGomez, Ayelen LucianaIngaramo, Paola InésBosquiazzo, Veronica LisLuque, Enrique HugoMuñoz de Toro, Monica MilagrosKass, LauraESTROGEN RECEPTORGLYPHOSATE-BASED HERBICIDEMALE RATSMAMMARY GLANDMAST CELLShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated. At PND21, GBH-exposed male rats exhibited greater development of the mammary gland with increased stromal collagen organization and terminal end buds (TEBs) compared to control rats. At PND60, the number of TEBs remained high and was accompanied by an increase in mast cell infiltration, proliferation and ESR1 expression in GBH-exposed male rats. In contrast, no effects were observed in E2 and T serum levels and AR expression in both days studied. Our results showed that a postnatal subacute treatment with GBH induces endocrine-disrupting effects in the male mammary gland in vivo, altering its normal development.Fil: Altamirano, Gabriela Anahí. Universidad Nacional del Litoral; ArgentinaFil: Delconte, Melisa. Universidad Nacional del Litoral; ArgentinaFil: Gomez, Ayelen Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Ingaramo, Paola Inés. Universidad Nacional del Litoral; ArgentinaFil: Bosquiazzo, Veronica Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Luque, Enrique Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; ArgentinaFil: Kass, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaPergamon-Elsevier Science Ltd2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86491Altamirano, Gabriela Anahí; Delconte, Melisa; Gomez, Ayelen Luciana; Ingaramo, Paola Inés; Bosquiazzo, Veronica Lis; et al.; Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 118; 8-2018; 111-1180278-6915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0278691518303004info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fct.2018.05.011info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:10Zoai:ri.conicet.gov.ar:11336/86491instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:10.796CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
title Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
spellingShingle Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
Altamirano, Gabriela Anahí
ESTROGEN RECEPTOR
GLYPHOSATE-BASED HERBICIDE
MALE RATS
MAMMARY GLAND
MAST CELLS
title_short Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
title_full Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
title_fullStr Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
title_full_unstemmed Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
title_sort Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
dc.creator.none.fl_str_mv Altamirano, Gabriela Anahí
Delconte, Melisa
Gomez, Ayelen Luciana
Ingaramo, Paola Inés
Bosquiazzo, Veronica Lis
Luque, Enrique Hugo
Muñoz de Toro, Monica Milagros
Kass, Laura
author Altamirano, Gabriela Anahí
author_facet Altamirano, Gabriela Anahí
Delconte, Melisa
Gomez, Ayelen Luciana
Ingaramo, Paola Inés
Bosquiazzo, Veronica Lis
Luque, Enrique Hugo
Muñoz de Toro, Monica Milagros
Kass, Laura
author_role author
author2 Delconte, Melisa
Gomez, Ayelen Luciana
Ingaramo, Paola Inés
Bosquiazzo, Veronica Lis
Luque, Enrique Hugo
Muñoz de Toro, Monica Milagros
Kass, Laura
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ESTROGEN RECEPTOR
GLYPHOSATE-BASED HERBICIDE
MALE RATS
MAMMARY GLAND
MAST CELLS
topic ESTROGEN RECEPTOR
GLYPHOSATE-BASED HERBICIDE
MALE RATS
MAMMARY GLAND
MAST CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated. At PND21, GBH-exposed male rats exhibited greater development of the mammary gland with increased stromal collagen organization and terminal end buds (TEBs) compared to control rats. At PND60, the number of TEBs remained high and was accompanied by an increase in mast cell infiltration, proliferation and ESR1 expression in GBH-exposed male rats. In contrast, no effects were observed in E2 and T serum levels and AR expression in both days studied. Our results showed that a postnatal subacute treatment with GBH induces endocrine-disrupting effects in the male mammary gland in vivo, altering its normal development.
Fil: Altamirano, Gabriela Anahí. Universidad Nacional del Litoral; Argentina
Fil: Delconte, Melisa. Universidad Nacional del Litoral; Argentina
Fil: Gomez, Ayelen Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Ingaramo, Paola Inés. Universidad Nacional del Litoral; Argentina
Fil: Bosquiazzo, Veronica Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Luque, Enrique Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; Argentina
Fil: Kass, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
description Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated. At PND21, GBH-exposed male rats exhibited greater development of the mammary gland with increased stromal collagen organization and terminal end buds (TEBs) compared to control rats. At PND60, the number of TEBs remained high and was accompanied by an increase in mast cell infiltration, proliferation and ESR1 expression in GBH-exposed male rats. In contrast, no effects were observed in E2 and T serum levels and AR expression in both days studied. Our results showed that a postnatal subacute treatment with GBH induces endocrine-disrupting effects in the male mammary gland in vivo, altering its normal development.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86491
Altamirano, Gabriela Anahí; Delconte, Melisa; Gomez, Ayelen Luciana; Ingaramo, Paola Inés; Bosquiazzo, Veronica Lis; et al.; Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 118; 8-2018; 111-118
0278-6915
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86491
identifier_str_mv Altamirano, Gabriela Anahí; Delconte, Melisa; Gomez, Ayelen Luciana; Ingaramo, Paola Inés; Bosquiazzo, Veronica Lis; et al.; Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 118; 8-2018; 111-118
0278-6915
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0278691518303004
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fct.2018.05.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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