Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI

Autores
Basquiera, Ana Lisa; Odstrcil Bobillo, María Silvina; Peroni, María Leticia; Sanchez Thomas, Diego; Vitriu, Adriana; Berro, Mariano; Rosales Ostriz, Belen; Milovic, Vera; Martinez Rolón, Juliana; Jaimovich, Gregorio; Hansen Krogh, Daniela; Tagliafichi, Viviana; Bisigniano, Liliana; Arbelbide, Jorge Alberto; Giunta, Diego Hernan
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7–165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5–275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions.
Fil: Basquiera, Ana Lisa. Hospital Italiano; Argentina. Hospital Privado Universitario de Córdoba; Argentina
Fil: Odstrcil Bobillo, María Silvina. Hospital Italiano; Argentina
Fil: Peroni, María Leticia. Hospital Italiano; Argentina
Fil: Sanchez Thomas, Diego. Hospital Italiano; Argentina
Fil: Vitriu, Adriana. Instituto Alexander Fleming; Argentina
Fil: Berro, Mariano. Universidad Austral; Argentina
Fil: Rosales Ostriz, Belen. Hospital de Clínicas José de San Martínbuenos Aires; Argentina
Fil: Milovic, Vera. Hospital Aleman; Argentina
Fil: Martinez Rolón, Juliana. Fundación Para Combatir la Leucemia; Argentina
Fil: Jaimovich, Gregorio. Fundación Favaloro; Argentina
Fil: Hansen Krogh, Daniela. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Tagliafichi, Viviana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Bisigniano, Liliana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Arbelbide, Jorge Alberto. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ALLOGENEIC
ARGENTINA
AUTOLOGOUS
EPIDEMIOLOGIC STUDIES
STEM CELL TRANSPLANTATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220339
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/220339
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAIBasquiera, Ana LisaOdstrcil Bobillo, María SilvinaPeroni, María LeticiaSanchez Thomas, DiegoVitriu, AdrianaBerro, MarianoRosales Ostriz, BelenMilovic, VeraMartinez Rolón, JulianaJaimovich, GregorioHansen Krogh, DanielaTagliafichi, VivianaBisigniano, LilianaArbelbide, Jorge AlbertoGiunta, Diego HernanALLOGENEICARGENTINAAUTOLOGOUSEPIDEMIOLOGIC STUDIESSTEM CELL TRANSPLANTATIONhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7–165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5–275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions.Fil: Basquiera, Ana Lisa. Hospital Italiano; Argentina. Hospital Privado Universitario de Córdoba; ArgentinaFil: Odstrcil Bobillo, María Silvina. Hospital Italiano; ArgentinaFil: Peroni, María Leticia. Hospital Italiano; ArgentinaFil: Sanchez Thomas, Diego. Hospital Italiano; ArgentinaFil: Vitriu, Adriana. Instituto Alexander Fleming; ArgentinaFil: Berro, Mariano. Universidad Austral; ArgentinaFil: Rosales Ostriz, Belen. Hospital de Clínicas José de San Martínbuenos Aires; ArgentinaFil: Milovic, Vera. Hospital Aleman; ArgentinaFil: Martinez Rolón, Juliana. Fundación Para Combatir la Leucemia; ArgentinaFil: Jaimovich, Gregorio. Fundación Favaloro; ArgentinaFil: Hansen Krogh, Daniela. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Tagliafichi, Viviana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Bisigniano, Liliana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Arbelbide, Jorge Alberto. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220339Basquiera, Ana Lisa; Odstrcil Bobillo, María Silvina; Peroni, María Leticia; Sanchez Thomas, Diego; Vitriu, Adriana; et al.; Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI; Elsevier; Hematology, Transfusion and Cell Therapy; 45; 2; 4-2023; 224-2342531-13792531-1387CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2531137922000451info:eu-repo/semantics/altIdentifier/doi/10.1016/j.htct.2022.02.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:45:26Zoai:ri.conicet.gov.ar:11336/220339instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:45:27.213CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
title Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
spellingShingle Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
Basquiera, Ana Lisa
ALLOGENEIC
ARGENTINA
AUTOLOGOUS
EPIDEMIOLOGIC STUDIES
STEM CELL TRANSPLANTATION
title_short Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
title_full Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
title_fullStr Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
title_full_unstemmed Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
title_sort Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
dc.creator.none.fl_str_mv Basquiera, Ana Lisa
Odstrcil Bobillo, María Silvina
Peroni, María Leticia
Sanchez Thomas, Diego
Vitriu, Adriana
Berro, Mariano
Rosales Ostriz, Belen
Milovic, Vera
Martinez Rolón, Juliana
Jaimovich, Gregorio
Hansen Krogh, Daniela
Tagliafichi, Viviana
Bisigniano, Liliana
Arbelbide, Jorge Alberto
Giunta, Diego Hernan
author Basquiera, Ana Lisa
author_facet Basquiera, Ana Lisa
Odstrcil Bobillo, María Silvina
Peroni, María Leticia
Sanchez Thomas, Diego
Vitriu, Adriana
Berro, Mariano
Rosales Ostriz, Belen
Milovic, Vera
Martinez Rolón, Juliana
Jaimovich, Gregorio
Hansen Krogh, Daniela
Tagliafichi, Viviana
Bisigniano, Liliana
Arbelbide, Jorge Alberto
Giunta, Diego Hernan
author_role author
author2 Odstrcil Bobillo, María Silvina
Peroni, María Leticia
Sanchez Thomas, Diego
Vitriu, Adriana
Berro, Mariano
Rosales Ostriz, Belen
Milovic, Vera
Martinez Rolón, Juliana
Jaimovich, Gregorio
Hansen Krogh, Daniela
Tagliafichi, Viviana
Bisigniano, Liliana
Arbelbide, Jorge Alberto
Giunta, Diego Hernan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALLOGENEIC
ARGENTINA
AUTOLOGOUS
EPIDEMIOLOGIC STUDIES
STEM CELL TRANSPLANTATION
topic ALLOGENEIC
ARGENTINA
AUTOLOGOUS
EPIDEMIOLOGIC STUDIES
STEM CELL TRANSPLANTATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7–165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5–275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions.
Fil: Basquiera, Ana Lisa. Hospital Italiano; Argentina. Hospital Privado Universitario de Córdoba; Argentina
Fil: Odstrcil Bobillo, María Silvina. Hospital Italiano; Argentina
Fil: Peroni, María Leticia. Hospital Italiano; Argentina
Fil: Sanchez Thomas, Diego. Hospital Italiano; Argentina
Fil: Vitriu, Adriana. Instituto Alexander Fleming; Argentina
Fil: Berro, Mariano. Universidad Austral; Argentina
Fil: Rosales Ostriz, Belen. Hospital de Clínicas José de San Martínbuenos Aires; Argentina
Fil: Milovic, Vera. Hospital Aleman; Argentina
Fil: Martinez Rolón, Juliana. Fundación Para Combatir la Leucemia; Argentina
Fil: Jaimovich, Gregorio. Fundación Favaloro; Argentina
Fil: Hansen Krogh, Daniela. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Tagliafichi, Viviana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Bisigniano, Liliana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Arbelbide, Jorge Alberto. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7–165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5–275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions.
publishDate 2023
dc.date.none.fl_str_mv 2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220339
Basquiera, Ana Lisa; Odstrcil Bobillo, María Silvina; Peroni, María Leticia; Sanchez Thomas, Diego; Vitriu, Adriana; et al.; Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI; Elsevier; Hematology, Transfusion and Cell Therapy; 45; 2; 4-2023; 224-234
2531-1379
2531-1387
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220339
identifier_str_mv Basquiera, Ana Lisa; Odstrcil Bobillo, María Silvina; Peroni, María Leticia; Sanchez Thomas, Diego; Vitriu, Adriana; et al.; Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI; Elsevier; Hematology, Transfusion and Cell Therapy; 45; 2; 4-2023; 224-234
2531-1379
2531-1387
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2531137922000451
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.htct.2022.02.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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