Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
- Autores
- Basquiera, Ana Lisa; Odstrcil Bobillo, María Silvina; Peroni, María Leticia; Sanchez Thomas, Diego; Vitriu, Adriana; Berro, Mariano; Rosales Ostriz, Belen; Milovic, Vera; Martinez Rolón, Juliana; Jaimovich, Gregorio; Hansen Krogh, Daniela; Tagliafichi, Viviana; Bisigniano, Liliana; Arbelbide, Jorge Alberto; Giunta, Diego Hernan
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7–165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5–275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions.
Fil: Basquiera, Ana Lisa. Hospital Italiano; Argentina. Hospital Privado Universitario de Córdoba; Argentina
Fil: Odstrcil Bobillo, María Silvina. Hospital Italiano; Argentina
Fil: Peroni, María Leticia. Hospital Italiano; Argentina
Fil: Sanchez Thomas, Diego. Hospital Italiano; Argentina
Fil: Vitriu, Adriana. Instituto Alexander Fleming; Argentina
Fil: Berro, Mariano. Universidad Austral; Argentina
Fil: Rosales Ostriz, Belen. Hospital de Clínicas José de San Martínbuenos Aires; Argentina
Fil: Milovic, Vera. Hospital Aleman; Argentina
Fil: Martinez Rolón, Juliana. Fundación Para Combatir la Leucemia; Argentina
Fil: Jaimovich, Gregorio. Fundación Favaloro; Argentina
Fil: Hansen Krogh, Daniela. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Tagliafichi, Viviana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Bisigniano, Liliana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Arbelbide, Jorge Alberto. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
ALLOGENEIC
ARGENTINA
AUTOLOGOUS
EPIDEMIOLOGIC STUDIES
STEM CELL TRANSPLANTATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/220339
Ver los metadatos del registro completo
id |
CONICETDig_fb5fecb23565a2e14f2239b7ca62ee62 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/220339 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAIBasquiera, Ana LisaOdstrcil Bobillo, María SilvinaPeroni, María LeticiaSanchez Thomas, DiegoVitriu, AdrianaBerro, MarianoRosales Ostriz, BelenMilovic, VeraMartinez Rolón, JulianaJaimovich, GregorioHansen Krogh, DanielaTagliafichi, VivianaBisigniano, LilianaArbelbide, Jorge AlbertoGiunta, Diego HernanALLOGENEICARGENTINAAUTOLOGOUSEPIDEMIOLOGIC STUDIESSTEM CELL TRANSPLANTATIONhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7–165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5–275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions.Fil: Basquiera, Ana Lisa. Hospital Italiano; Argentina. Hospital Privado Universitario de Córdoba; ArgentinaFil: Odstrcil Bobillo, María Silvina. Hospital Italiano; ArgentinaFil: Peroni, María Leticia. Hospital Italiano; ArgentinaFil: Sanchez Thomas, Diego. Hospital Italiano; ArgentinaFil: Vitriu, Adriana. Instituto Alexander Fleming; ArgentinaFil: Berro, Mariano. Universidad Austral; ArgentinaFil: Rosales Ostriz, Belen. Hospital de Clínicas José de San Martínbuenos Aires; ArgentinaFil: Milovic, Vera. Hospital Aleman; ArgentinaFil: Martinez Rolón, Juliana. Fundación Para Combatir la Leucemia; ArgentinaFil: Jaimovich, Gregorio. Fundación Favaloro; ArgentinaFil: Hansen Krogh, Daniela. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Tagliafichi, Viviana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Bisigniano, Liliana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Arbelbide, Jorge Alberto. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220339Basquiera, Ana Lisa; Odstrcil Bobillo, María Silvina; Peroni, María Leticia; Sanchez Thomas, Diego; Vitriu, Adriana; et al.; Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI; Elsevier; Hematology, Transfusion and Cell Therapy; 45; 2; 4-2023; 224-2342531-13792531-1387CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2531137922000451info:eu-repo/semantics/altIdentifier/doi/10.1016/j.htct.2022.02.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:15Zoai:ri.conicet.gov.ar:11336/220339instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:15.316CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI |
title |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI |
spellingShingle |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI Basquiera, Ana Lisa ALLOGENEIC ARGENTINA AUTOLOGOUS EPIDEMIOLOGIC STUDIES STEM CELL TRANSPLANTATION |
title_short |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI |
title_full |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI |
title_fullStr |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI |
title_full_unstemmed |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI |
title_sort |
Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI |
dc.creator.none.fl_str_mv |
Basquiera, Ana Lisa Odstrcil Bobillo, María Silvina Peroni, María Leticia Sanchez Thomas, Diego Vitriu, Adriana Berro, Mariano Rosales Ostriz, Belen Milovic, Vera Martinez Rolón, Juliana Jaimovich, Gregorio Hansen Krogh, Daniela Tagliafichi, Viviana Bisigniano, Liliana Arbelbide, Jorge Alberto Giunta, Diego Hernan |
author |
Basquiera, Ana Lisa |
author_facet |
Basquiera, Ana Lisa Odstrcil Bobillo, María Silvina Peroni, María Leticia Sanchez Thomas, Diego Vitriu, Adriana Berro, Mariano Rosales Ostriz, Belen Milovic, Vera Martinez Rolón, Juliana Jaimovich, Gregorio Hansen Krogh, Daniela Tagliafichi, Viviana Bisigniano, Liliana Arbelbide, Jorge Alberto Giunta, Diego Hernan |
author_role |
author |
author2 |
Odstrcil Bobillo, María Silvina Peroni, María Leticia Sanchez Thomas, Diego Vitriu, Adriana Berro, Mariano Rosales Ostriz, Belen Milovic, Vera Martinez Rolón, Juliana Jaimovich, Gregorio Hansen Krogh, Daniela Tagliafichi, Viviana Bisigniano, Liliana Arbelbide, Jorge Alberto Giunta, Diego Hernan |
author2_role |
author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
ALLOGENEIC ARGENTINA AUTOLOGOUS EPIDEMIOLOGIC STUDIES STEM CELL TRANSPLANTATION |
topic |
ALLOGENEIC ARGENTINA AUTOLOGOUS EPIDEMIOLOGIC STUDIES STEM CELL TRANSPLANTATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7–165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5–275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions. Fil: Basquiera, Ana Lisa. Hospital Italiano; Argentina. Hospital Privado Universitario de Córdoba; Argentina Fil: Odstrcil Bobillo, María Silvina. Hospital Italiano; Argentina Fil: Peroni, María Leticia. Hospital Italiano; Argentina Fil: Sanchez Thomas, Diego. Hospital Italiano; Argentina Fil: Vitriu, Adriana. Instituto Alexander Fleming; Argentina Fil: Berro, Mariano. Universidad Austral; Argentina Fil: Rosales Ostriz, Belen. Hospital de Clínicas José de San Martínbuenos Aires; Argentina Fil: Milovic, Vera. Hospital Aleman; Argentina Fil: Martinez Rolón, Juliana. Fundación Para Combatir la Leucemia; Argentina Fil: Jaimovich, Gregorio. Fundación Favaloro; Argentina Fil: Hansen Krogh, Daniela. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina Fil: Tagliafichi, Viviana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina Fil: Bisigniano, Liliana. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina Fil: Arbelbide, Jorge Alberto. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina Fil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results: Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7–165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5–275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p < 0.01). No changes were observed for unrelated donors during the study period. Conclusions: Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/220339 Basquiera, Ana Lisa; Odstrcil Bobillo, María Silvina; Peroni, María Leticia; Sanchez Thomas, Diego; Vitriu, Adriana; et al.; Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI; Elsevier; Hematology, Transfusion and Cell Therapy; 45; 2; 4-2023; 224-234 2531-1379 2531-1387 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/220339 |
identifier_str_mv |
Basquiera, Ana Lisa; Odstrcil Bobillo, María Silvina; Peroni, María Leticia; Sanchez Thomas, Diego; Vitriu, Adriana; et al.; Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI; Elsevier; Hematology, Transfusion and Cell Therapy; 45; 2; 4-2023; 224-234 2531-1379 2531-1387 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2531137922000451 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.htct.2022.02.008 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614086913949696 |
score |
13.070432 |