Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina
- Autores
- Niborski, Leticia Laura; Grippo, Vanina; Lafon, Sonia Olga; Levitus, Gabriela Laura; García Bournissen, Facundo; Ramirez Gomez, Juan Carlos; Burgos, Juan Miguel; Bisio, Margarita María Catalina; Juiz, Natalia Anahí; Ayala, Vilma; Coppede, María; Herrera, Verónica; López, Crescencia; Contreras, Ana; Gomez, Karina Andrea; Elean, Juan C.; Mujica, Hugo D.; Schijman, Alejandro Gabriel; Levin, Mariano Jorge; Longhi, Silvia Andrea
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, was conducted from endemic areas of northern Argentina. Follow-up was possible in 107 out of them and blood samples were taken for serology and PCR assays before and 2, 3, 6, 12, 24 and 36 months after treatment initiation. Reactivity against Trypanosoma cruzi lysate and recombinant antigens was measured by ELISA. The rate of decrease of antibody titers showed nonlinear kinetics with an abrupt drop within the first three months after initiation of treatment for all studied antigens, followed by a plateau displaying a low decay until the end of follow-up. At this point, anti-B13, anti-1F8 and anti-JL7 titers were relatively close to the cut-off line, while anti-T. cruzi antibodies still remained positive. At baseline, 60.8% (45/74) of analysed patients tested positive for parasite DNA by PCR and during the follow-up period in 34 out of 45 positive samples (75.5%) could not be detected T. cruzi DNA. Our results suggest that these antigens might be useful as early markers for monitoring antiparasitic treatment in chronic Chagas disease.
Fil: Niborski, Leticia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Grippo, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Lafon, Sonia Olga. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Levitus, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: García Bournissen, Facundo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramirez Gomez, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Burgos, Juan Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Bisio, Margarita María Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Ayala, Vilma. Centro Asistencial Cáritas Diocesana; Argentina
Fil: Coppede, María. Centro Asistencial Cáritas Diocesana; Argentina
Fil: Herrera, Verónica. Centro Asistencial Cáritas Diocesana; Argentina
Fil: López, Crescencia. Centro Asistencial Cáritas Diocesana; Argentina
Fil: Contreras, Ana. Centro Asistencial Cáritas Diocesana; Argentina
Fil: Gomez, Karina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Elean, Juan C.. Centro Asistencial Cáritas Diocesana; Argentina
Fil: Mujica, Hugo D.. Centro Asistencial Cáritas Diocesana; Argentina. Hospital Zonal de Añatuya; Argentina
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Longhi, Silvia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina - Materia
-
ADVERSE EFFECTS
BENZNIDAZOLE TREATMENT
CHRONIC CHAGAS DISEASE
SEROLOGICAL FOLLOW-UP
TRYPANOSOMA CRUZI - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/114690
Ver los metadatos del registro completo
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Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern ArgentinaNiborski, Leticia LauraGrippo, VaninaLafon, Sonia OlgaLevitus, Gabriela LauraGarcía Bournissen, FacundoRamirez Gomez, Juan CarlosBurgos, Juan MiguelBisio, Margarita María CatalinaJuiz, Natalia AnahíAyala, VilmaCoppede, MaríaHerrera, VerónicaLópez, CrescenciaContreras, AnaGomez, Karina AndreaElean, Juan C.Mujica, Hugo D.Schijman, Alejandro GabrielLevin, Mariano JorgeLonghi, Silvia AndreaADVERSE EFFECTSBENZNIDAZOLE TREATMENTCHRONIC CHAGAS DISEASESEROLOGICAL FOLLOW-UPTRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, was conducted from endemic areas of northern Argentina. Follow-up was possible in 107 out of them and blood samples were taken for serology and PCR assays before and 2, 3, 6, 12, 24 and 36 months after treatment initiation. Reactivity against Trypanosoma cruzi lysate and recombinant antigens was measured by ELISA. The rate of decrease of antibody titers showed nonlinear kinetics with an abrupt drop within the first three months after initiation of treatment for all studied antigens, followed by a plateau displaying a low decay until the end of follow-up. At this point, anti-B13, anti-1F8 and anti-JL7 titers were relatively close to the cut-off line, while anti-T. cruzi antibodies still remained positive. At baseline, 60.8% (45/74) of analysed patients tested positive for parasite DNA by PCR and during the follow-up period in 34 out of 45 positive samples (75.5%) could not be detected T. cruzi DNA. Our results suggest that these antigens might be useful as early markers for monitoring antiparasitic treatment in chronic Chagas disease.Fil: Niborski, Leticia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Grippo, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Lafon, Sonia Olga. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Levitus, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: García Bournissen, Facundo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ramirez Gomez, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Burgos, Juan Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Bisio, Margarita María Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Ayala, Vilma. Centro Asistencial Cáritas Diocesana; ArgentinaFil: Coppede, María. Centro Asistencial Cáritas Diocesana; ArgentinaFil: Herrera, Verónica. Centro Asistencial Cáritas Diocesana; ArgentinaFil: López, Crescencia. Centro Asistencial Cáritas Diocesana; ArgentinaFil: Contreras, Ana. Centro Asistencial Cáritas Diocesana; ArgentinaFil: Gomez, Karina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Elean, Juan C.. Centro Asistencial Cáritas Diocesana; ArgentinaFil: Mujica, Hugo D.. Centro Asistencial Cáritas Diocesana; Argentina. Hospital Zonal de Añatuya; ArgentinaFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Longhi, Silvia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFundação Oswaldo Cruz2016-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114690Niborski, Leticia Laura; Grippo, Vanina; Lafon, Sonia Olga; Levitus, Gabriela Laura; García Bournissen, Facundo; et al.; Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 111; 6; 6-2016; 365-3710074-02761678-8060CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000600365info:eu-repo/semantics/altIdentifier/url/https://memorias.ioc.fiocruz.br/article/6135/0006_serological-based-monitoring-of-a-cohort-of-patients-with-chronic-chagas-disease-treated-with-benznidazole-in-a-highly-endemic-area-of-northern-argentinainfo:eu-repo/semantics/altIdentifier/doi/10.1590/0074-02760160006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:52Zoai:ri.conicet.gov.ar:11336/114690instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:52.858CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina |
| title |
Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina |
| spellingShingle |
Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina Niborski, Leticia Laura ADVERSE EFFECTS BENZNIDAZOLE TREATMENT CHRONIC CHAGAS DISEASE SEROLOGICAL FOLLOW-UP TRYPANOSOMA CRUZI |
| title_short |
Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina |
| title_full |
Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina |
| title_fullStr |
Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina |
| title_full_unstemmed |
Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina |
| title_sort |
Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina |
| dc.creator.none.fl_str_mv |
Niborski, Leticia Laura Grippo, Vanina Lafon, Sonia Olga Levitus, Gabriela Laura García Bournissen, Facundo Ramirez Gomez, Juan Carlos Burgos, Juan Miguel Bisio, Margarita María Catalina Juiz, Natalia Anahí Ayala, Vilma Coppede, María Herrera, Verónica López, Crescencia Contreras, Ana Gomez, Karina Andrea Elean, Juan C. Mujica, Hugo D. Schijman, Alejandro Gabriel Levin, Mariano Jorge Longhi, Silvia Andrea |
| author |
Niborski, Leticia Laura |
| author_facet |
Niborski, Leticia Laura Grippo, Vanina Lafon, Sonia Olga Levitus, Gabriela Laura García Bournissen, Facundo Ramirez Gomez, Juan Carlos Burgos, Juan Miguel Bisio, Margarita María Catalina Juiz, Natalia Anahí Ayala, Vilma Coppede, María Herrera, Verónica López, Crescencia Contreras, Ana Gomez, Karina Andrea Elean, Juan C. Mujica, Hugo D. Schijman, Alejandro Gabriel Levin, Mariano Jorge Longhi, Silvia Andrea |
| author_role |
author |
| author2 |
Grippo, Vanina Lafon, Sonia Olga Levitus, Gabriela Laura García Bournissen, Facundo Ramirez Gomez, Juan Carlos Burgos, Juan Miguel Bisio, Margarita María Catalina Juiz, Natalia Anahí Ayala, Vilma Coppede, María Herrera, Verónica López, Crescencia Contreras, Ana Gomez, Karina Andrea Elean, Juan C. Mujica, Hugo D. Schijman, Alejandro Gabriel Levin, Mariano Jorge Longhi, Silvia Andrea |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ADVERSE EFFECTS BENZNIDAZOLE TREATMENT CHRONIC CHAGAS DISEASE SEROLOGICAL FOLLOW-UP TRYPANOSOMA CRUZI |
| topic |
ADVERSE EFFECTS BENZNIDAZOLE TREATMENT CHRONIC CHAGAS DISEASE SEROLOGICAL FOLLOW-UP TRYPANOSOMA CRUZI |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, was conducted from endemic areas of northern Argentina. Follow-up was possible in 107 out of them and blood samples were taken for serology and PCR assays before and 2, 3, 6, 12, 24 and 36 months after treatment initiation. Reactivity against Trypanosoma cruzi lysate and recombinant antigens was measured by ELISA. The rate of decrease of antibody titers showed nonlinear kinetics with an abrupt drop within the first three months after initiation of treatment for all studied antigens, followed by a plateau displaying a low decay until the end of follow-up. At this point, anti-B13, anti-1F8 and anti-JL7 titers were relatively close to the cut-off line, while anti-T. cruzi antibodies still remained positive. At baseline, 60.8% (45/74) of analysed patients tested positive for parasite DNA by PCR and during the follow-up period in 34 out of 45 positive samples (75.5%) could not be detected T. cruzi DNA. Our results suggest that these antigens might be useful as early markers for monitoring antiparasitic treatment in chronic Chagas disease. Fil: Niborski, Leticia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Grippo, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Lafon, Sonia Olga. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Levitus, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: García Bournissen, Facundo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ramirez Gomez, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Burgos, Juan Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Bisio, Margarita María Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Ayala, Vilma. Centro Asistencial Cáritas Diocesana; Argentina Fil: Coppede, María. Centro Asistencial Cáritas Diocesana; Argentina Fil: Herrera, Verónica. Centro Asistencial Cáritas Diocesana; Argentina Fil: López, Crescencia. Centro Asistencial Cáritas Diocesana; Argentina Fil: Contreras, Ana. Centro Asistencial Cáritas Diocesana; Argentina Fil: Gomez, Karina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Elean, Juan C.. Centro Asistencial Cáritas Diocesana; Argentina Fil: Mujica, Hugo D.. Centro Asistencial Cáritas Diocesana; Argentina. Hospital Zonal de Añatuya; Argentina Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Longhi, Silvia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina |
| description |
This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, was conducted from endemic areas of northern Argentina. Follow-up was possible in 107 out of them and blood samples were taken for serology and PCR assays before and 2, 3, 6, 12, 24 and 36 months after treatment initiation. Reactivity against Trypanosoma cruzi lysate and recombinant antigens was measured by ELISA. The rate of decrease of antibody titers showed nonlinear kinetics with an abrupt drop within the first three months after initiation of treatment for all studied antigens, followed by a plateau displaying a low decay until the end of follow-up. At this point, anti-B13, anti-1F8 and anti-JL7 titers were relatively close to the cut-off line, while anti-T. cruzi antibodies still remained positive. At baseline, 60.8% (45/74) of analysed patients tested positive for parasite DNA by PCR and during the follow-up period in 34 out of 45 positive samples (75.5%) could not be detected T. cruzi DNA. Our results suggest that these antigens might be useful as early markers for monitoring antiparasitic treatment in chronic Chagas disease. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-06 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/114690 Niborski, Leticia Laura; Grippo, Vanina; Lafon, Sonia Olga; Levitus, Gabriela Laura; García Bournissen, Facundo; et al.; Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 111; 6; 6-2016; 365-371 0074-0276 1678-8060 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/114690 |
| identifier_str_mv |
Niborski, Leticia Laura; Grippo, Vanina; Lafon, Sonia Olga; Levitus, Gabriela Laura; García Bournissen, Facundo; et al.; Serological based monitoring of a cohort of patients with chronic chagas disease treated with benznidazole in a highly endemic area of Northern Argentina; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 111; 6; 6-2016; 365-371 0074-0276 1678-8060 CONICET Digital CONICET |
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eng |
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eng |
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