Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain
- Autores
- Kasanetz, Fernando; Nevian, Thomas
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Neuropathic pain induces changes in neuronal excitability and synaptic connectivity in deep layers of the anterior cingulate cortex (ACC) that play a central role in the sensory, emotional and affective consequences of the disease. However, how this impacts ACC in vivo activity is not completely understood. Using a mouse model, we found that neuropathic pain caused an increase in ACC in vivo activity, as measured by the indirect activity marker c-Fos and juxtacellular electrophysiological recordings. The enhanced firing rate of ACC neurons in lesioned animals was based on a change in the firing pattern towards bursting activity. Despite the proportion of ACC neurons recruited by noxious stimuli was unchanged during neuropathic pain, responses to noxious stimuli were characterized by increased bursting. Thus, this change in coding pattern may have important implications for the processing of nociceptive information in the ACC and could be of great interest to guide the search for new treatment strategies for chronic pain.
Fil: Kasanetz, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Nevian, Thomas. University of Bern; Suiza - Materia
-
Neuropathic pain
Anterior Cingulate Cortex
Burst firing
electrophysiology - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/172670
Ver los metadatos del registro completo
id |
CONICETDig_fa1fcb883e2d94dce37664d25b20d073 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/172670 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic painKasanetz, FernandoNevian, ThomasNeuropathic painAnterior Cingulate CortexBurst firingelectrophysiologyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neuropathic pain induces changes in neuronal excitability and synaptic connectivity in deep layers of the anterior cingulate cortex (ACC) that play a central role in the sensory, emotional and affective consequences of the disease. However, how this impacts ACC in vivo activity is not completely understood. Using a mouse model, we found that neuropathic pain caused an increase in ACC in vivo activity, as measured by the indirect activity marker c-Fos and juxtacellular electrophysiological recordings. The enhanced firing rate of ACC neurons in lesioned animals was based on a change in the firing pattern towards bursting activity. Despite the proportion of ACC neurons recruited by noxious stimuli was unchanged during neuropathic pain, responses to noxious stimuli were characterized by increased bursting. Thus, this change in coding pattern may have important implications for the processing of nociceptive information in the ACC and could be of great interest to guide the search for new treatment strategies for chronic pain.Fil: Kasanetz, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Nevian, Thomas. University of Bern; SuizaNature2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/172670Kasanetz, Fernando; Nevian, Thomas; Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain; Nature; Scientific Reports; 11; 1; 12-2021; 1-102045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-021-03652-7info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-03652-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:06:24Zoai:ri.conicet.gov.ar:11336/172670instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:06:24.517CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain |
title |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain |
spellingShingle |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain Kasanetz, Fernando Neuropathic pain Anterior Cingulate Cortex Burst firing electrophysiology |
title_short |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain |
title_full |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain |
title_fullStr |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain |
title_full_unstemmed |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain |
title_sort |
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain |
dc.creator.none.fl_str_mv |
Kasanetz, Fernando Nevian, Thomas |
author |
Kasanetz, Fernando |
author_facet |
Kasanetz, Fernando Nevian, Thomas |
author_role |
author |
author2 |
Nevian, Thomas |
author2_role |
author |
dc.subject.none.fl_str_mv |
Neuropathic pain Anterior Cingulate Cortex Burst firing electrophysiology |
topic |
Neuropathic pain Anterior Cingulate Cortex Burst firing electrophysiology |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Neuropathic pain induces changes in neuronal excitability and synaptic connectivity in deep layers of the anterior cingulate cortex (ACC) that play a central role in the sensory, emotional and affective consequences of the disease. However, how this impacts ACC in vivo activity is not completely understood. Using a mouse model, we found that neuropathic pain caused an increase in ACC in vivo activity, as measured by the indirect activity marker c-Fos and juxtacellular electrophysiological recordings. The enhanced firing rate of ACC neurons in lesioned animals was based on a change in the firing pattern towards bursting activity. Despite the proportion of ACC neurons recruited by noxious stimuli was unchanged during neuropathic pain, responses to noxious stimuli were characterized by increased bursting. Thus, this change in coding pattern may have important implications for the processing of nociceptive information in the ACC and could be of great interest to guide the search for new treatment strategies for chronic pain. Fil: Kasanetz, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Nevian, Thomas. University of Bern; Suiza |
description |
Neuropathic pain induces changes in neuronal excitability and synaptic connectivity in deep layers of the anterior cingulate cortex (ACC) that play a central role in the sensory, emotional and affective consequences of the disease. However, how this impacts ACC in vivo activity is not completely understood. Using a mouse model, we found that neuropathic pain caused an increase in ACC in vivo activity, as measured by the indirect activity marker c-Fos and juxtacellular electrophysiological recordings. The enhanced firing rate of ACC neurons in lesioned animals was based on a change in the firing pattern towards bursting activity. Despite the proportion of ACC neurons recruited by noxious stimuli was unchanged during neuropathic pain, responses to noxious stimuli were characterized by increased bursting. Thus, this change in coding pattern may have important implications for the processing of nociceptive information in the ACC and could be of great interest to guide the search for new treatment strategies for chronic pain. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/172670 Kasanetz, Fernando; Nevian, Thomas; Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain; Nature; Scientific Reports; 11; 1; 12-2021; 1-10 2045-2322 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/172670 |
identifier_str_mv |
Kasanetz, Fernando; Nevian, Thomas; Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain; Nature; Scientific Reports; 11; 1; 12-2021; 1-10 2045-2322 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-021-03652-7 info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-03652-7 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature |
publisher.none.fl_str_mv |
Nature |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1846782421287043072 |
score |
12.982451 |